The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 612
Special Issue Editor
Interests: inflammation; natural killer (NK) cells; immune response; metabolism; vaccines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cytokines are small proteins that play a vital role in regulating the growth, inhibition, and activity of various cells. Some serve as signals to activate functions of the immune system; others are involved in more open spectra, affecting different cells. Due to their beneficial effects, several pharmacological options have been designed to facilitate the treatment of various diseases. Antibodies against specific cytokines have been successfully used in therapy and can interfere with the inflammatory response, decreasing disease burden.
Conversely, autoantibodies targeting cytokines have also been identified; their role is considered significant, at least in the immune response. It is thought they may neutralize and inhibit the physiological function of the cytokine. It is plausible that additional autoantibodies against other cytokines other than those related to the immune response exist and affect other functions therein. Autoantibodies against cytokines have also been observed in healthy individuals, and their function remains ambiguous.
This Special Issue is intended to examine the functions of cytokines within various physiological and pathological contexts and address the role of autoantibodies targeting cytokines. Contributions exploring pharmacological methods for modulating cytokine effects, including delivery mechanisms and inhibitory strategies, are also encouraged. Submissions from both human and animal model studies are welcome.
You may choose our Joint Special Issue in Immuno.
Prof. Dr. Juan Bautista De Sanctis
Guest Editor
Manuscript Submission Information
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Keywords
- cytokine
- autoantibodies
- cytokine therapy
- cytokine inhibition
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