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Toxicity Mechanism of Emerging Pollutants: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 777

Special Issue Editors


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Guest Editor
Laboratory of Bioelectrochemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, 15-245 Bialystok, Poland
Interests: lipid membranes; liposomes; emerging pollutant; toxicology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory of Bioelectrochemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland
Interests: liposomes; biomimetic membranes; electrokinetic phenomena for membrane charge; microelectrophoresis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The group of emerging pollutant compounds includes environmental contaminants such as pharmaceuticals, disinfectants, personal care products, endocrine disruptors, pesticides, microplastics, and many others. Their impact on human health is often associated with cyto- and genotoxicity, and their effects include diseases such as diabetes, obesity, cancer, circulatory system diseases, and fertility disorders. These substances are detected in the environment in very low concentrations, but they still cause harmful effects in aquatic, soil, and human organisms. That is why it is so important to investigate the mechanisms of their action and discover ways to counteract their toxic properties. The aim of this Special Issue is to collect information on the occurrence, identification, and mechanisms of action of compounds from the emerging pollutants group. This collection of articles will include the most up-to-date articles on the mechanisms of action of environmental contaminants and methods of counteracting the toxicity of various xenobiotics, using the most modern methodologies. Therefore, this Special Issue is open to comprehensive reviews and original articles and covers the following topics:

  • Occurrence and identification of emerging pollutants;
  • Mechanisms of action of emerging pollutants;
  • Cytotoxicity and genotoxicity;
  • Molecular mechanisms of action of xenobiotics;
  • Pesticides, microplastics, and cancer;
  • Alleviation of the toxicity of contaminants.

Prof. Dr. Monika Naumowicz
Dr. Joanna Kotyńska
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging pollutant
  • toxicology
  • cancer
  • EDC
  • pesticides
  • microplastic
  • human cell lines
  • environment
  • molecular mechanisms

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Published Papers (1 paper)

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Research

15 pages, 2755 KiB  
Article
Interaction of Polystyrene Nanoplastics with Biomolecules and Environmental Pollutants: Effects on Human Hepatocytes
by Barbara Mognetti, Claudio Cecone, Katia Fancello, Astrid Saraceni, Erika Cottone and Patrizia Bovolin
Int. J. Mol. Sci. 2025, 26(7), 2899; https://doi.org/10.3390/ijms26072899 - 22 Mar 2025
Viewed by 455
Abstract
The inevitable exposure of humans to micro/nanoplastics has become a pressing global environmental issue, with growing concerns regarding their impact on health. While the direct effects of micro/nanoplastics on human health remain largely unknown, increasing attention is being given to their potential role [...] Read more.
The inevitable exposure of humans to micro/nanoplastics has become a pressing global environmental issue, with growing concerns regarding their impact on health. While the direct effects of micro/nanoplastics on human health remain largely unknown, increasing attention is being given to their potential role as carriers of environmental pollutants and organic substances. This study investigates the direct toxicity of 500 nm polystyrene nanoplastics (NPs) on human hepatocytes (HepG2) in vitro, both alone and in combination with cadmium (Cd), a hazardous heavy metal and a prevalent environmental pollutant. One-hour exposure to 100 µg/mL of NPs causes a significant increase in ROS production (+25% compared to control) but cell viability remains unaffected even at concentrations much higher than environmental levels. Interestingly, NPs significantly reduce Cd cytotoxicity at LC50 concentrations (cell viability compared to control: 55.4% for 50 µM Cd, 66.9% for 50 µM Cd + 10 µg/mL NPs, 68.4% for 50 µM Cd + 100 µg/mL NPs). Additionally, NPs do not alter the cellular lipid content after short-term exposure (24 h). However, when Cd and fatty acids are added to the medium, NPs appear to sequester fatty acids, reducing their availability and impairing their uptake by cells in a dose-dependent manner. We confirmed by Dynamic Light Scattering and Scanning Electron Microscopy the interaction between NPs, Cd and free fatty acids. Although polystyrene NPs exhibited minimal cytotoxicity in our experimental model, collectively our findings suggest that predicting the effects of cell exposure to NPs is extremely challenging, due to the potential interaction between NPs, environmental pollutants and specific components of the biological matrix. Full article
(This article belongs to the Special Issue Toxicity Mechanism of Emerging Pollutants: 2nd Edition)
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