ijms-logo

Journal Browser

Journal Browser

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 3009

Special Issue Editor


E-Mail Website
Guest Editor
Department of Life, Health, and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: extracellular vesicles; malignant tumors; anti-inflammatory; anti-fibrosis

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) are cell-derived particles that integrate with physiological processes in all life forms, having been identified in prokaryotes, animals, and plants. They encompass molecules that exert crucial biological effects in cell-to-cell communication and cell homeostasis. Notably, EVs play a critical role in cancer progression and metastasis.

This Special Issue, entitled "Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook", aims to cover a selection of recent research topics and current review articles in the field of EVs in cancer. Our focus will be on the pro/anti-oncogenic, pro/anti-angiogenic, and pro/anti-metastatic functions mediated by EVs, whether secreted by cancer cells or by the metastatic and primary tumor microenvironment. We warmly encourage article submissions on the effects of bacterial- and plant-derived EVs on tumor physiology, as well as on the topic of the theranostic potential of EVs as tools for precision medicine in cancer. Adherence to MISEV2023 guidelines will be considered a strong plus for original articles.

Dr. Alfredo Cappariello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mammalian extracellular vesicles
  • plant-derived extracellular vesicles
  • bacterial-derived extracellular vesicles
  • cancer progression
  • cell migration and invasion
  • tumor microenvironment
  • epithelial-to-mesenchymal transition (EMT)
  • drug delivery
  • diagnostics
  • precision medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

24 pages, 17226 KB  
Article
Comparison Bioinformatic Analysis of Extracellular Vesicles-Related Genes and MicroRNAs in Breast Cancer
by Durmus Ayan, Serife Buket Bozkurt Polat, Esma Ozmen and Mehmet Ali Gul
Int. J. Mol. Sci. 2025, 26(12), 5906; https://doi.org/10.3390/ijms26125906 - 19 Jun 2025
Viewed by 752
Abstract
Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with treatment challenges due to the lack of targeted therapies. Extracellular vesicles (EVs) play a crucial role in BC progression by carrying bioactive molecules. This study analyzed EV-associated molecules (ENPEP, TIMP1, [...] Read more.
Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with treatment challenges due to the lack of targeted therapies. Extracellular vesicles (EVs) play a crucial role in BC progression by carrying bioactive molecules. This study analyzed EV-associated molecules (ENPEP, TIMP1, CD36, MARCKS, DAB2, CXCL14, miR-181b-5p, miR-222-3p) using bioinformatics tools. We used GEPIA2; Human Protein Atlas (HPA) 24.0; bc-GenExMiner v5.1; UALCAN 2022; Kaplan–Meier plotter 2025; ENCORI database v2.0; Enrichr-KG web tool 2021; Cancer Hallmark Enrichment tool 2025; Tumor, Normal, and Metastatic (TNM) plot database 2025; MicroRNA Target Prediction Database 6.0; TargetScan 8.0; and STRING database 12.0. CD36, DAB2, and CXCL14 were significantly downregulated, while TIMP1 was upregulated in BC tissues (p < 0.05). CD36, CXCL14, and DAB2 were predominantly low in triple-negative and basal-like subtypes, whereas TIMP1 was higher in HER2+, ER+, and PR+ tumors (p < 0.01). These changes correlated with promoter methylation patterns. Higher TIMP1, DAB2, and CXCL14 levels were associated with improved overall survival (p < 0.05). miR-222-3p was downregulated and positively correlated with TIMP1 and DAB2, while miR-181b-5p was upregulated and negatively correlated with CXCL14. TNM analysis confirmed these expression changes. Functional enrichment linked these molecules to key cancer hallmarks, including proliferation and angiogenesis. CD36, DAB2, CXCL14, TIMP1, miR-222-3p, and miR-181b-5p may serve as biomarkers for BC pathogenesis and potential therapeutic targets. Further studies are needed to validate these findings. Full article
Show Figures

Graphical abstract

Review

Jump to: Research

30 pages, 2460 KB  
Review
Recent Advances of Small Extracellular Vesicles for the Regulation and Function of Cancer-Associated Fibroblasts
by Chengdong Liang, Maoye Wang, Yongli Huang, Judy Wai Ping Yam, Xu Zhang and Xiaoxin Zhang
Int. J. Mol. Sci. 2024, 25(23), 12548; https://doi.org/10.3390/ijms252312548 - 22 Nov 2024
Cited by 2 | Viewed by 1835
Abstract
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells [...] Read more.
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells to recipient cells. Previous studies have demonstrated that CAFs play important roles in tumor progression by regulating tumor cell proliferation, metastasis, therapeutic resistance, and metabolism via sEVs. In turn, tumor-derived sEVs can also regulate the activation and phenotype switch of CAFs. The dynamic crosstalk between CAFs and cancer cells via sEVs could ultimately determine cancer progression. In this review, we summarized the recent advance of the biological roles and underlying mechanisms of sEVs in mediating CAF-tumor cell interaction and its impact on cancer progression. We also reviewed the clinical applications of tumor- and CAF-derived sEVs, which could identify novel potential targets and biomarkers for cancer diagnosis, therapy, and prognosis. Full article
Show Figures

Figure 1

Back to TopTop