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Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches
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Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 515

Special Issue Editor

Prof. Dr. Ligia Petrica

E-Mail Website
Guest Editor
Department of Nephrology, Centre for Molecular Research in Nephrology and Vascular Disease, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania
Interests: chronic kidney disease; diabetic kidney disease; epigenetics; proteomics; lipidomics; metabolomics; mitochondrial dysfunction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches”, provides an in-depth exploration of the pathophysiological processes underlying chronic kidney disease (CKD) and the latest advances in potential therapeutic strategies. Contributions from leading researchers in the field present cutting-edge insights into the molecular mechanisms that drive CKD progression, including inflammation, fibrosis, and mitochondrial dysfunction, alongside novel biomarkers for early detection and disease monitoring.

This Special Issue also highlights the roles of genetic and epigenetic factors in CKD susceptibility and progression, providing a comprehensive understanding of the intricate interplay between genetic predisposition and environmental influences. Regarding therapeutics, this Special Issue delves into promising approaches, such as targeted drug therapies, gene editing, stem cell treatments, and precision medicine, for improving patient outcomes.

By combining basic research with clinical applications, this Special Issue acts as an essential resource for researchers, clinicians, and healthcare professionals working to tackle the global burden of CKD and develop effective, personalized therapeutic interventions.

Prof. Dr. Ligia Petrica
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics
  • epigenetics
  • inflammation
  • metabolomics
  • oxiative stress

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Published Papers (1 paper)

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Research

19 pages, 946 KiB  
Article
Targeted Analysis of Serum and Urinary Metabolites for Early Chronic Kidney Disease
by Mihaela-Roxana Glavan, Carmen Socaciu, Andreea Iulia Socaciu, Oana Milas, Florica Gadalean, Octavian M. Cretu, Adrian Vlad, Danina M. Muntean, Flaviu Bob, Anca Suteanu, Dragos Catalin Jianu, Maria Stefan, Lavinia Marcu, Silvia Ienciu and Ligia Petrica
Int. J. Mol. Sci. 2025, 26(7), 2862; https://doi.org/10.3390/ijms26072862 - 21 Mar 2025
Viewed by 363
Abstract
Chronic kidney disease (CKD) has become one of the most rapidly advancing diseases of the century, contributing significantly to increased mortality and morbidity. Metabolomics presents a promising approach to understanding CKD pathogenesis and identifying novel biomarkers for early diagnosis. This study evaluated serum [...] Read more.
Chronic kidney disease (CKD) has become one of the most rapidly advancing diseases of the century, contributing significantly to increased mortality and morbidity. Metabolomics presents a promising approach to understanding CKD pathogenesis and identifying novel biomarkers for early diagnosis. This study evaluated serum and urine metabolomic profiles in CKD patients with declining glomerular filtration rates (eGFR). Using targeted metabolomics, we quantified seven potential metabolites in blood and urine samples from 20 healthy individuals and 99 CKD patients staged by eGFR according to the KDIGO guidelines. The analysis was conducted using ultra-high performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. The metabolites investigated included L-phenylalanine, L-methionine, arginine, indoxyl sulfate, kynurenic acid, and L-acetylcarnitine. Quantitative assessments were performed using pure standards and validated through methods such as the limit of detection (LOD) and limit of quantification (LOQ). The findings identified potential biomarkers for early CKD diagnosis: in serum, L-phenylalanine, L-methionine, arginine, kynurenic acid, and indoxyl sulfate, while L-acetylcarnitine was significant in urine. These biomarkers could provide valuable insights into CKD progression and support in developing more effective diagnostic tools for early intervention. Full article
(This article belongs to the Special Issue Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches)
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