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Molecular Insights into Antimicrobial Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 470

Special Issue Editor


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Guest Editor
Department of Pharmacology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: antibiotics; antimicrobial properties; antibiotic resistance to antibiotics; adverse effects of antibiotics; biomaterials; nanotechnology; biomedical applications; drug delivery systems; biocompatible polymers; wound healing; cancer therapy
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Special Issue Information

Dear Colleagues,

We are delighted to introduce this Special Issue, "Molecular Insights into Antimicrobial Activity", which aims to showcase recent advancements, innovative research, and emerging trends in the field of antimicrobial science. This issue seeks to address critical challenges and explore transformative solutions in the fight against antimicrobial resistance, which is a growing global health concern. With an urgent need for new strategies, compounds, and a deeper understanding of antimicrobial mechanisms, this Special Issue provides a platform for sharing groundbreaking discoveries and novel approaches that could shape the future of this vital field.

We invite original research articles and reviews to be submitted on a wide range of topics, including but not limited to the following:

  • The development of novel antimicrobial compounds and the exploration of their mechanisms of action;
  • Innovative techniques for evaluating antimicrobial efficacy;
  • Understanding resistance mechanisms and strategies to counteract them;
  • Applications of antimicrobial agents in clinical, agricultural, or industrial settings;
  • Cross-disciplinary research that links antimicrobial science with fields like nanotechnology, genomics, or synthetic biology.

The publication of this Special Issue offers authors a chance to engage with a wide audience and gain high visibility within the antimicrobial research community. We encourage contributors to emphasize this topic’s novelty, significance, and potential biomedical impact in their submissions.

Join us in advancing the field of antimicrobial science by contributing to this Special Issue. Together, we can progress in addressing one of the most pressing challenges of our time.

Prof. Dr. Liliana Mititelu Tartau
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • antimicrobial agents
  • antimicrobial peptides
  • phytochemicals with antimicrobial properties
  • antimicrobial synergy
  • pathogen-specific targeting
  • antimicrobial resistance
  • biomedical science
  • nanotechnology in antimicrobials
  • genomic

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Published Papers (1 paper)

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Research

13 pages, 2359 KiB  
Article
Transcriptomic Analysis of Campylobacter jejuni Following Exposure to Gaseous Chlorine Dioxide Reveals an Oxidative Stress Response
by Gretchen E. Dykes, Yiping He, Tony Jin, Xuetong Fan, Joe Lee, Sue Reed and Joseph Capobianco
Int. J. Mol. Sci. 2025, 26(7), 3254; https://doi.org/10.3390/ijms26073254 - 1 Apr 2025
Viewed by 286
Abstract
Gaseous chlorine dioxide (ClO2) is a potent antimicrobial agent used to control microbial contamination in food and water. This study evaluates the bactericidal activity of gaseous ClO2 released from a sodium chlorite (NaClO2) pad against Campylobacter jejuni. [...] Read more.
Gaseous chlorine dioxide (ClO2) is a potent antimicrobial agent used to control microbial contamination in food and water. This study evaluates the bactericidal activity of gaseous ClO2 released from a sodium chlorite (NaClO2) pad against Campylobacter jejuni. Exposure to a low concentration (0.4 mg/L) of dissolved ClO2 for 2 h resulted in a >93% reduction of C. jejuni, highlighting the bacterium’s extreme sensitivity to gaseous ClO2. To elucidate the molecular mechanism of ClO2-induced bactericidal action, transcriptomic analysis was conducted using RNA sequencing (RNA-seq). The results indicate that C. jejuni responds to ClO2-induced oxidative stress by upregulating genes involved in reactive oxygen species (ROS) detoxification (sodB, ahpC, katA, msrP, and trxB), iron transport (ceuBCD, cfbpABC, and chuBCD), phosphate transport (pstSCAB), and DNA repair (rdgB and mutY). Reverse transcription-quantitative PCR (RT-qPCR) validated the increased expression of oxidative stress response genes but not general stress response genes (spoT, dnaK, and groES). These findings provide insights into the antimicrobial mechanism of ClO2, demonstrating that oxidative damage to essential cellular components results in bacterial cell death. Full article
(This article belongs to the Special Issue Molecular Insights into Antimicrobial Activity)
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