Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 107
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neutrophil extracellular traps (NETs), released by activated neutrophils, play a crucial role in various human diseases, including sepsis, multi-drug resistant infections, autoimmune disorders, cardiovascular diseases, and cancer. Excessive or dysregulated NET formation contributes to tissue damage, inflammation, and thrombosis. In autoimmune diseases like systemic lupus erythematosus and rheumatoid arthritis, NETs serve as autoantigens, sustaining the autoimmune response. In cardiovascular diseases, they promote thrombus formation and atherosclerosis progression, while in cancer, they facilitate tumor metastasis and a pro-tumorigenic microenvironment.
Despite their recognized pathological roles, the precise mechanisms regulating NET formation and clearance remain unclear. Further research is needed to understand the triggers, signaling pathways, and degradation mechanisms of NETs, as well as their therapeutic potential. This Special Issue aims to consolidate current knowledge on NETs in human diseases, highlighting molecular mechanisms and clinical relevance through original research and review articles.
Dr. Eisuke F. Sato
Guest Editor
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Keywords
- neutrophil extracellular traps (NETs)
- neutrophils
- inflammation
- autoimmune diseases
- cardiovascular diseases
- tumor metastasis
- thrombosis
- molecular mechanisms
- disease progression
- therapeutic targets
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