Biomarkers in Precision Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 196
Special Issue Editor
Interests: biomarkers; therapeutic targets and compounds for Parkinson's disease and other neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are progressive disorders characterized by the gradual loss of functional neurons in central and peripheral nervous systems, often leading to the demise of affected subjects. These conditions, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), typically manifest as cognitive decline, motor dysfunction, or both, severely impacting patients' quality of life. The underlying mechanisms are complex and multifactorial, involving protein misfolding, the accumulation of toxic aggregates, oxidative stress, mitochondrial dysfunction, and neuroinflammation. The lack of effective early diagnostic tools and disease-modifying treatments underscores the urgency of identifying reliable biomarkers to enhance our understanding, monitoring, and treatment of these devastating conditions. Biomarkers such as α-synuclein (α-syn) seeds, amyloid-beta (Aβ), tau proteins, and neurofilament light chain (NfL) have demonstrated potential in identifying early disease stages, tracking disease progression, and predicting outcomes in conditions like AD and PD. Advanced techniques, including neuroimaging, cerebrospinal fluid analysis, and blood-based assays, are being developed to enhance biomarker accuracy and accessibility. These innovations not only enable early and precise diagnosis but also facilitate personalized treatment strategies by identifying specific pathological pathways. The integration of biomarker discovery with artificial intelligence and multi-omics approaches holds promise for revolutionizing the management of neurodegenerative disorders.
The aim of this Special Issue is to discuss new promising biomarkers and novel techniques and approaches for biomarker identification and validation, which can support clinical practice regarding human neurodegenerative disorders.
Dr. Zhidong Zhou
Guest Editor
Manuscript Submission Information
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Keywords
- biomarkers
- precision medicine
- novel techniques
- artificial intelligence
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