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Functional Genomics in Translational Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 3098

Special Issue Editors


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Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu Uni-versity of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania
Interests: translational medicine, alternative to animal test cancer biomarkers coding and non-coding genes
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania
Interests: functional genomics; drug discovery; drug resistance

E-Mail Website
Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania
Interests: functional genomics; personalized medicine; neurological disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming Special Issue, which aims to present the application of functional genomics with a focus on its potential in healthcare and disease management.

This Special Issue is aimed at publishing papers that are related to early detection and prognosis, emphasizing novel therapeutic targets, and addressing the critical components of drug response. We also aim to highlight studies that explore how functional genomics can identify molecular influencing drug efficacy and resistance, thereby contributing to more effective and tailored therapeutic approaches. Furthermore, we are interested in methodological papers that discuss the development and optimization of new technologies and techniques in functional genomics. We expect to highlight the most recent advancements in functional genomics; we hope to drive forward the development of innovative solutions for disease diagnosis, treatment, or prevention.

Topics of interest include the following:

  • Molecular mechanisms of diseases;
  • Biomarkers for early detection and prognosis;
  • Novel therapeutic targets;
  • Drug response and resistance;
  • Bioinformatic tools for functional genomics, omics applications, and data integration.

Dr. Cornelia Braicu
Dr. Oana Zanoaga
Dr. Ștefan Strilciuc
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional genomics
  • omics approaches
  • drug response/resistance
  • therapeutic targets
  • genomics and transcriptomic alteration
  • bioinformatic analysis
  • data integration
  • human disease
  • personalized medicine

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Published Papers (2 papers)

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Research

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11 pages, 3734 KiB  
Article
MIMR: Development of a Web-Based System for miRNA and mRNA Integrated Analysis
by Dayeon Kim and Younhee Ko
Int. J. Mol. Sci. 2024, 25(21), 11819; https://doi.org/10.3390/ijms252111819 - 4 Nov 2024
Viewed by 1355
Abstract
The human body is a complex network of systems that is harmonized with multiple biological components. To understand these interactions is very challenging. With rapid development of advanced sequencing technologies, massive amounts of data such as mRNA, miRNA are rapidly accumulated. The integrated [...] Read more.
The human body is a complex network of systems that is harmonized with multiple biological components. To understand these interactions is very challenging. With rapid development of advanced sequencing technologies, massive amounts of data such as mRNA, miRNA are rapidly accumulated. The integrated analysis of mRNA–miRNA has brought an extensive understanding of complex biological systems and pathological mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that intricately regulate target gene products, resulting in the inhibition of gene expression. While these miRNAs play crucial roles in essential biological processes—ranging from immunity and metabolism to cell death—their specific impacts on diseases remain unknown. Recent studies have been focused on the integration of miRNA and mRNA expression to reveal the underlying biological pathways and mechanisms responsible for disease manifestation. We proposed a novel approach for integrative analysis of miRNA and mRNA expression data and developed MIMR (Integrative Analysis of miRNA and mRNA), a web-based application that leverages the Random Walk with Restart (RWR) algorithm. MIMR incorporates both direct and indirect interactions by utilizing protein–protein interaction (PPI) networks and experimentally validated mRNA–miRNA target interactions. MIMR provides comprehensive results, including novel pathological pathways associated with a specific disease and interactive network diagrams representing the mRNAs and miRNAs. We applied it to Alzheimer and breast cancer data and successfully identified the novel biological pathways related to these diseases. In summary, MIMR will offer a deeper insight into the hidden mechanisms of diseases and identify potential therapeutic strategies through integrated analysis of miRNAs and mRNAs. Full article
(This article belongs to the Special Issue Functional Genomics in Translational Medicine)
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Review

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17 pages, 1126 KiB  
Review
Role of miR-181 Family Members in Stroke: Insights into Mechanisms and Therapeutic Potential
by Cornelia Braicu, Fior Dafin Mureșanu, Ekaterina Isachesku, Natan Bornstein, Saša R. Filipović, Stefan Strilciuc and Adrian Pana
Int. J. Mol. Sci. 2025, 26(2), 440; https://doi.org/10.3390/ijms26020440 - 7 Jan 2025
Viewed by 1322
Abstract
Stroke is a major cause of mortality and long-term disability worldwide, making early diagnosis and effective treatment crucial for reducing its impact. In response to the limited efficacy of current treatments, alternative therapeutic strategies, such as novel biomarkers and therapies, are emerging to [...] Read more.
Stroke is a major cause of mortality and long-term disability worldwide, making early diagnosis and effective treatment crucial for reducing its impact. In response to the limited efficacy of current treatments, alternative therapeutic strategies, such as novel biomarkers and therapies, are emerging to address this critical unmet medical need. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Due to their dysregulation, they have been implicated in the onset and progression of various diseases. Recent research highlighted the important role of miR-181 family members in the context of stroke. Polymorphisms such as rs322931 in miR-181b are associated with increased stroke risk. miR-181 family members are aberrantly expressed and related to various aspects of stroke pathology, affecting inflammatory responses or neuronal survival. We provide a comprehensive overview of how alterations in miR-181 expression influence stroke mechanisms and their potential as therapeutic targets. Full article
(This article belongs to the Special Issue Functional Genomics in Translational Medicine)
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