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Advances in Post-Mortem Toxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 4908

Special Issue Editor


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Guest Editor
Department of Forensic Medicine and Forensic Toxicology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland
Interests: forensic and clinical pathology; autopsy; forensic toxicology; forensic entomology

Special Issue Information

Dear Colleagues,

This Special Issue will present the progress made in post-mortem toxicology and current research directions in this field. Contemporary toxicology is developing dynamically and multi-directionally. It collaborates with other fields of science, such as analytical and forensic chemistry, clinical and experimental toxicology, forensic medicine, and genetics, with particular emphasis on pharmaco- and toxicogenetics. It is worth highlighting areas of interest such as the search for new alternative materials for toxicological testing; the diagnosis of poisoning with new psychoactive substances, including fatal poisonings with opioids and other drugs; the diagnosis of suicide using inorganic compounds; the continuous development of analytical methods; the use of artificial intelligence; the use of molecular genetic testing; and the limits of reporting obtained test results and their proper interpretation, which is crucial for the proper functioning of the justice system.

Prof. Dr. Rafał Skowronek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • post-mortem toxicology
  • fatal poisoning
  • new psychoactive substances
  • opioids
  • analytical methods
  • interpretation of test results

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Published Papers (2 papers)

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11 pages, 315 KB  
Article
A Fatal Case Involving Chronic Intravenous Use of Homemade Methcathinone Derived from Pseudoephedrine Tablets: Post-Mortem Concentrations, Health Risk, and Medicolegal Aspect
by Karolina Nowak, Paweł Szpot and Marcin Zawadzki
Int. J. Mol. Sci. 2025, 26(24), 11974; https://doi.org/10.3390/ijms262411974 - 12 Dec 2025
Viewed by 1456
Abstract
Intravenous use of methcathinone synthesized at home from over-the-counter medications containing pseudoephedrine or ephedrine poses significant health risks, including neurotoxicity, severe infections, and, in some cases, fatal outcomes. This study explores the public health implications of this hazardous practice. Post-mortem femoral blood and [...] Read more.
Intravenous use of methcathinone synthesized at home from over-the-counter medications containing pseudoephedrine or ephedrine poses significant health risks, including neurotoxicity, severe infections, and, in some cases, fatal outcomes. This study explores the public health implications of this hazardous practice. Post-mortem femoral blood and vitreous humor samples were analyzed using UHPLC-QqQ-MS/MS. The method enabled differentiation of ephedrine (a metabolite of methcathinone in this context) from pseudoephedrine (a precursor), along with the identification of relevant metabolites. A literature review was also conducted to contextualize associated health risks. The validated method accurately quantified methcathinone, pseudoephedrine, ephedrine, and identified their metabolites. The simultaneous detection of the final product and unreacted precursor supported the hypothesis of chronic intravenous use of homemade methcathinone. Literature data emphasized the risks of manganese-induced encephalopathy, injection-related infections, and the harmful effects of intravenously administered tablet excipients. These issues disproportionately affect marginalized and high-risk populations. This case highlights the diagnostic value of the method and its importance for monitoring the health impacts of illicit stimulant use. Effective responses should include public education, harm reduction strategies, surveillance of emerging drug trends, and, above all, the application of advanced analytical methods capable of comprehensive evaluation in such cases. Full article
(This article belongs to the Special Issue Advances in Post-Mortem Toxicology)
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11 pages, 739 KB  
Case Report
Double Fatal Sodium Nitrite Poisoning—Double Homicide, Extended Suicide, or Suicide and Accident?
by Anna Smędra, Katarzyna Wochna, Mateusz Lisowski, Agnieszka Skulska-Birgiel, Marta Suchan and Jarosław Berent
Int. J. Mol. Sci. 2026, 27(1), 218; https://doi.org/10.3390/ijms27010218 - 24 Dec 2025
Cited by 1 | Viewed by 3006
Abstract
Recent years have seen an increasing number of cases of intentional poisoning with sodium nitrite. This is due, in part, to its inexpensive and readily available nature, and to the growth of social media. This paper briefly reviews the toxicity of sodium nitrite [...] Read more.
Recent years have seen an increasing number of cases of intentional poisoning with sodium nitrite. This is due, in part, to its inexpensive and readily available nature, and to the growth of social media. This paper briefly reviews the toxicity of sodium nitrite and the mechanism of death associated with its consumption and then presents a case of the fatal sodium nitrite poisoning of two sisters within a few hours of each other. It goes on to discuss both the growing problem of mental disorders, particularly among young people, and the potential diagnostic difficulties associated with sodium nitrite poisoning. It also addresses the approach to determining the manner of death, which may not be evident to the investigator; an accurate investigation is, of course, essential, as mistakes can result in the failure to identify the actual perpetrators and even lead to false accusations of guilt. Full article
(This article belongs to the Special Issue Advances in Post-Mortem Toxicology)
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