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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor István Csonka

submission deadline 31 Jul 2026 | Viewed by 466 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Understanding Cardiotoxicity: From Mechanisms to Therapeutic Implications

edited by

Anna A. Borowiec

submission deadline 31 Jul 2026 | 1 articles | Viewed by 464 | Submission Open

Keywords: cardiotoxicity; mechanisms of cardiotoxicity; cancer-therapy-related cardiac dysfunction; chemotherapy-related cardiotoxicity; radiotherapy-related cardiotoxicity; immunotherapy-related cardiotoxicity; cardioprotection; molecular pathways; oxidative stress; apoptosis; cardiac biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Podocyte Research: Molecular Insights and Clinical Applications

edited by

Hans Lorenzo

submission deadline 31 Jul 2026 | Viewed by 459 | Submission Open

Keywords: podocytes; glomerular filtration barrier; slit diaphragm; podocyte injury; proteinuria; focal segmental glomerulosclerosis; nephrotic syndrome; cell death; non-coding RNAs; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Production of Bioactive Compounds by Microbes: Biosynthetic Pathway Elucidation and Metabolic Engineering

edited by

Yongjun Wei

, Ziqiao Yuan and Ying Zhang

submission deadline 31 Jul 2026 | Viewed by 439 | Submission Open

Keywords: bioacitve compounds; engineered microbes; biosynthetic pathway; metabolic engineering; synthetic biology; metabolic reprogramming

(This special issue belongs to the Section Molecular Microbiology)

Genetic and Molecular Mechanisms in Neurological Diseases

edited by Serena Barral

submission deadline 31 Jul 2026 | Viewed by 420 | Submission Open

Keywords: neurological diseases; genetic mechanisms; molecular pathways; human neuronal models; brain organoids; iPSC-derived neural cells; neurodevelopment and neurodegeneration; disease modeling; human in vitro systems; genotype-phenotype relationships

(This special issue belongs to the Section Molecular Neurobiology)

Calcium Dynamics in Disease: Mechanisms and Therapeutic Opportunities

edited by

Valeria Magnelli

submission deadline 31 Jul 2026 | Viewed by 392 | Submission Open

Keywords: calcium signaling; homeostasis; deregulation; calcium imbalance

(This special issue belongs to the Section Biochemistry)

Advances in Ferrocene-Based Molecular Research: Synthesis, Properties, and Applications

edited by

Mojca Čakić Semenčić

submission deadline 31 Jul 2026 | Viewed by 385 | Submission Open

Keywords: ferrocene; organometallic chemistry; bioorganometallic chemistry; ferrocene derivatives; synthesis; applications; bioconjugates

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Tools in Chronic Diseases

edited by

Elena Grossini

submission deadline 31 Jul 2026 | 1 articles | Viewed by 376 | Submission Open

Keywords: cell-free therapy; exosomes; immunomodulation; molecular mechanisms; regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Therapeutic Potential of Organic Compound in Diseases

edited by

Katarzyna Kotwica-Mojzych

submission deadline 31 Jul 2026 | Viewed by 364 | Submission Open

Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

DNA Damage and DNA Repair in Health and Diseases

edited by Silvina B. Nadin

submission deadline 31 Jul 2026 | Viewed by 354 | Submission Open

Keywords: genome instability; DNA damage response; DNA repair mechanisms; cancer; therapeutic targets; preclinical studies; translational studies; DNA repair and immune system; PARP inhibitors; BRCA1/2

(This special issue belongs to the Section Molecular Biology)

Strategies and Visions for Nano- and Molecular-Design Materials in Future Photovoltaic Applications

edited by

Ivana Validžić

submission deadline 31 Jul 2026 | Viewed by 354 | Submission Open

Keywords: novel photovoltaic materials; semiconductors; perovskites; organic materials; dye-sensitized materials; bio-based materials; advanced materials; innovative energy materials

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of GPCR Signaling

edited by

Kyeong-Man Kim

submission deadline 31 Jul 2026 | Viewed by 348 | Submission Open

Keywords: biased signaling; allosteric modulation; receptor conformations; spatiotemporal signaling; allosteric modulation; receptor trafficking; signaling networks; structure-based drug design

(This special issue belongs to the Section Biochemistry)

Selected Papers from the HSG-2025 Conference

edited by

Marsel Kabilov

submission deadline 31 Jul 2026 | Viewed by 335 | Submission Open

Keywords: metagenomics; genomics; metabarcoding; next-generation sequencing; transcriptomics; translatomics; NGS data analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into T Cell Exhaustion and Tumor Immune Evasion

edited by

Apostolos Zaravinos

submission deadline 31 Jul 2026 | Viewed by 320 | Submission Open

Keywords: T cell exhaustion; immune evasion; tumor microenvironment; immune checkpoints; immunometabolism; epigenetics; cancer immunology; molecular immunotherapy; single-cell analysis; transcriptional regulation

(This special issue belongs to the Section Molecular Immunology)

Cellular and Molecular Pathogenesis of Gynecologic Diseases: Focus on Uterine and Ovarian Dysfunction

edited by

Seung-Yup Ku

submission deadline 31 Jul 2026 | Viewed by 319 | Submission Open

Keywords: molecular pathogenesis; uterine diseases; ovarian dysfunction; cellular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

JAK/STAT Pathway in Stem Cell Biology

edited by Willis Li

submission deadline 31 Jul 2026 | Viewed by 318 | Submission Open

Keywords: JAK/STAT signaling; stem cell self-renewal; cellular differentiation; pluripotency; hematopoietic stem cells; signal transduction; cytokine receptors; transcriptional regulation; stem cell niche; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Nutrients and Oxidative Stress

edited by

Duško P. Blagojević

submission deadline 31 Jul 2026 | Viewed by 317 | Submission Open

Keywords: oxidative stress; redox regulation; reactive oxygen species; antioxidants; nutrients; functional food

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Striated Muscle Physiology

edited by Xuesong Feng

submission deadline 31 Jul 2026 | Viewed by 304 | Submission Open

Keywords: striated muscle; physiology; myopathies; mitochondria; mechanotransduction; epigenetics regulation; muscle aging; muscle regeneration

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Targeting Ion Channels for Novel Therapeutics

edited by María A. Gandini

submission deadline 31 Jul 2026 | Viewed by 300 | Submission Open

Keywords: ion channel; channelopathies; membrane trafficking; post-translation regulation; electrophysiology; signal transduction

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Natural Bioactive Compounds

edited by

Dušanka Kitić

submission deadline 31 Jul 2026 | Viewed by 299 | Submission Open

Keywords: natural products pharmacology; plant secondary metabolites; molecular mechanisms; phyto-chemicals; signal transduction pathways; structure– activity relationships; natural product

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Relevant Molecules in the Process of Oxidative Stress

edited by

Anna De Maio

Carmen Di Giovanni

and

Anna Rita Bianchi

submission deadline 31 Jul 2026 | Viewed by 294 | Submission Open

Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidant enzymes; non-enzymatic antioxidants; poly(ADPribosyl)ation; transcription factors

(This special issue belongs to the Section Biochemistry)

Pathogenesis of Central Nervous System Disorders, Interplay and Multifaceted Role of Glial Cells and Neuroprotective Mechanisms

edited by Matilde Balbi

submission deadline 31 Jul 2026 | Viewed by 285 | Submission Open

Keywords: neurodegenerative disease; CNS disorders; glial cells; glia-cross talk; extracellular vesicles; calcium pathway; neuroinflammation; autophagy; excitotoxicity; glial phenotype

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Environmental Carcinogenesis

edited by Grażyna Gromadzka

submission deadline 31 Jul 2026 | Viewed by 275 | Submission Open

Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment

(This special issue belongs to the Section Molecular Toxicology)

The Relationship Between Cytokines and Autoimmune Diseases: New Insights

edited by

Edith Oregon-Romero

and

Christian Johana Baños-Hernández

submission deadline 31 Jul 2026 | Viewed by 273 | Submission Open

Keywords: cytokines; autoimmune diseases; biomarkers; therapeutic targets; etiology; pathophysiology

(This special issue belongs to the Section Molecular Immunology)

Natural Antioxidants in Human Health and Disease: Molecular Advances

edited by Aneta Kopeć

submission deadline 31 Jul 2026 | Viewed by 270 | Submission Open

Keywords: antioxidants; immune response; free radicals; mechanism of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nanomedicine for Cancer Diagnosis and Therapy

edited by

Suresh Thangudu

submission deadline 31 Jul 2026 | Viewed by 270 | Submission Open

Keywords: nanomaterials; multifunctional properties; anticancer nanotechnology; image guided nano platforms; in vivo evaluation; delivery approaches; immune-nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Genetic and Molecular Strategies to Soybean Improvement

edited by

Junming Sun

submission deadline 31 Jul 2026 | Viewed by 270 | Submission Open

Keywords: soybean; genome editing; CRISPR/Cas9; quantitative trait loci (QTL); marker-assisted selection; functional genomics; molecular breeding; crop improvement; gene expression; genetics and breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 31 Jul 2026 | Viewed by 268 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Host DNA Damage Responses in Virus Propagation and Human Disease

edited by Nimrat Chatterjee

submission deadline 31 Jul 2026 | Viewed by 265 | Submission Open

Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer

(This special issue belongs to the Section Molecular Microbiology)

Antioxidants in Healthspan Regulation: From Molecular Mechanisms to Cellular Signaling

edited by

Grzegorz Bartosz

and

Izabela Sadowska-Bartosz

submission deadline 31 Jul 2026 | Viewed by 260 | Submission Open

Keywords: antioxidant; reactive oxygen species; lifespan; healthspan; molecular mechanisms; cellular effects; supplementation

(This special issue belongs to the Section Biochemistry)

Lysosomal Storage Disorders: Molecular Pathogenesis and Next-Generation Therapeutics

edited by

Olga Amaral

and

Ari Zimran

submission deadline 31 Jul 2026 | Viewed by 257 | Submission Open

Keywords: lysosomal storage disorders; cellular mechanisms; multi-omics biomarkers; gene therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microfluidic Organ-on-a-Chip: Bridging Drug Discovery to Precision Medicine

edited by Yongjian Ai and Mengqi He

submission deadline 31 Jul 2026 | Viewed by 246 | Submission Open

Keywords: absorption; distribution; metabolism; excretion; toxicity; host– pathogen; host-immune; pharmacokinetic; pharmacodynamic; absorption; metabolism; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Targeted Cancer Therapeutics: Molecular Pathways and Precision Strategies

edited by

Kausik Bishayee

submission deadline 31 Jul 2026 | Viewed by 245 | Submission Open

Keywords: targeted cancer therapy; small molecules; combination therapy; inhibitors; cancer cell death and proliferation

(This special issue belongs to the Section Molecular Oncology)

Molecular Insight into Plant Bioactive Compounds: 2nd Edition

edited by

Karolina Wojtunik-Kulesza

submission deadline 31 Jul 2026 | Viewed by 241 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 3rd Edition

edited by

Andrés J. Cortés

submission deadline 31 Jul 2026 | Viewed by 237 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Mathematical Calculation and Modeling in Biology

edited by Nan Sheng

submission deadline 31 Jul 2026 | Viewed by 232 | Submission Open

Keywords: mathematical modeling; computational biology; machine/deep learning; molecular biology; molecular interactions; gene; protein; small molecule; computational drug design; multi-omics

(This special issue belongs to the Section Molecular Informatics)

New Mechanisms and Therapeutics in Neurological Diseases—5th Edition

edited by

Barbara Mroczko

submission deadline 31 Jul 2026 | Viewed by 230 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Oral and Periodontal Health

edited by

Giuseppina Malcangi

, Roxana Ioana Bordea and Grazia Marinelli

submission deadline 31 Jul 2026 | Viewed by 229 | Submission Open

Keywords: dental disease; dental materials; orthodontic diseases; growth factor; regenerative tissue; peritonitis; regulatory T cells; systemic disease; systemic inflammation; scaling and root planning

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epitranscriptomics: RNA Modifications and Function

edited by Caroline Vissers

submission deadline 31 Jul 2026 | Viewed by 227 | Submission Open

Keywords: epitranscriptome; methylation; mRNA; rRNA; RNA modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Glomerular Diseases, 2nd Edition

edited by

Gian Marco Ghiggeri

submission deadline 31 Jul 2026 | Viewed by 225 | Submission Open

Keywords: glomerulonephritis; proteinuria; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrition for Muscle Health and Metabolism

edited by

Hira Shakoor

submission deadline 31 Jul 2026 | Viewed by 225 | Submission Open

Keywords: nutrition; skeletal muscle; muscle metabolism; mitochondrial function; insulin sensitivity; myokines; metabolic health; metabolic disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Role of Ion Channels in Heart Health and Diseases

edited by Ernesto Alejandro Aiello

submission deadline 31 Jul 2026 | Viewed by 224 | Submission Open

Keywords: ion channels; heart; channelopathies; hypertrophy; heart failure; ischemia; hypertension; inflammation

(This special issue belongs to the Section Molecular Biology)

Recent Developments in Bioactive and Functional Nanomaterials

edited by Mónica Rosalía Jaime-Fonseca, José Abraham Balderas López and Miguel Angel Aguilar Méndez

submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open

Keywords: bioactives; nanostructured materials; nanoparticles; nanofibers; nanomedicine drug delivery; biosensors; smart food packaging; functional foods; sustainable agriculture

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research on Steroid Hormones and Sex Hormones

edited by

Eloísa Da Silveira Loss

submission deadline 31 Jul 2026 | Viewed by 221 | Submission Open

Keywords: membrane androgen receptors; G protein-coupled estrogen receptor; membrane progesterone receptors; membrane glucocorticoid receptor; genomic steroid receptors; rapid immune effects; non-genomic signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Interplay of Nanoparticles with Plant Physiology and Molecular Biology: Effects, Mechanisms and Agricultural Applications

edited by

Zaid Ulhassan

submission deadline 31 Jul 2026 | Viewed by 219 | Submission Open

Keywords: plant nano biology; abiotic stress tolerance; physiological and molecular mechanisms; nanotoxicology; detoxification strategies

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Research in Bioactive Compounds

edited by

Seiji Shioda

submission deadline 31 Jul 2026 | Viewed by 217 | Submission Open

Keywords: peptides; nervous system; feeding regulation; glucose; lipid metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Progress of Forensic Genetics

edited by

Mariano Guardado-Estrada

submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open

Keywords: forensic genetics; genomics; phenotyping; DNA sequencing; pedigree; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research of Host-Pathogen Interactions

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 31 Jul 2026 | Viewed by 215 | Submission Open

Keywords: host– pathogen interactions; host immunity during infection; new targets for resistant pathogens; molecular communication during infection; model systems in host– pathogen studies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on the Antioxidant, Anti-Inflammatory, and Antibacterial Activities of Natural Products

edited by

Carmen Lizette Del Toro Sánchez

and

Ariadna Thalia Bernal-Mercado

submission deadline 31 Jul 2026 | Viewed by 214 | Submission Open

Keywords: natural bioactive compounds; antioxidant mechanisms; anti-inflammatory pathways; antibacterial activity; agro-industrial byproducts; molecular docking; structure– activity relationship (SAR); omics technologies; drug delivery systems; nanobiotechnology; bioavailability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Dementia and Application of Biomarkers

edited by

Teresa Juárez-Cedillo

submission deadline 31 Jul 2026 | Viewed by 211 | Submission Open

Keywords: Alzheimer's; diagnosis; biological marker; protein; therapeutic target

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 901-950 on page 19 of 65.

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