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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Perspectives on Female Infertility and Fertility

edited by

Seung-Yup Ku

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: female infertility; molecular mechanisms of reproduction; oocyte maturation and development; reproductive aging; polycystic ovary syndrome; endometriosis; epigenetic regulation in reproduction; oxidative stress and mitochondrial dysfunction; reproductive biomarkers; precision medicine and regenerative therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Perspectives of Colloids for Biological Applications, 2nd Edition

edited by

Agnieszka Ewa Wia̧cek

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: colloids; emulsions; dispersions; stability; size distribution; zeta potential; optical/rheological properties; medicine; pharmaceuticals; cosmetics

(This special issue belongs to the Section Materials Science)

Sex Differences in Preclinical and Clinical Studies

edited by

Flavia Franconi

Valeria Raparelli

and

Ilaria Campesi

submission deadline 28 Feb 2026 | Viewed by 82 | Submission Open

Keywords: cellular and in vitro studies; genetic and epigenetic studies; intersectional studies; observational studies; pharmacological studies; pragmatic studies; randomized control trials; disease management

(This special issue belongs to the Section Molecular Biology)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 28 Feb 2026 | Viewed by 82 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology

edited by

Mariano Mastinu

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia

(This special issue belongs to the Section Molecular Biology)

RNA Biology and Regulation, 2nd Edition

edited by

Naoyuki Kataoka

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Angiogenesis: Mechanisms and Targets in a Wide Spectrum of Diseases

edited by Lei Phillip Wang

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: angiogenesis; immune– vascular interactions; cancer; autoimmune disease; neurodegenera-tion; blood– brain barrier; biomarkers; therapeutic targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights

edited by

Michele De Franco

submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open

Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Epigenetic Elicitation of Dormant Microorganisms for Anti-Cancer Therapy

edited by

Komal Anjum

submission deadline 28 Feb 2026 | Viewed by 77 | Submission Open

Keywords: dormant microbes; epigenetic; bioactive molecules; anti-cancer therapy; biosynthetic pathways; bioactive secondary metabolites

(This special issue belongs to the Section Molecular Genetics and Genomics)

Heterogeneous Catalysis Towards a Sustainable Future: Energy Conversion and Green Synthesis

edited by Chen Wu and

Shaodong Zhou

submission deadline 28 Feb 2026 | Viewed by 77 | Submission Open

Keywords: heterogeneous catalysis; CO2 hydrogenation; CO2 electroreduction; water splitting; Fischer-Tropsch synthesis; oxidative coupling of methane; methane dry reforming; green synthesis; fine chemicals; sustainable energy; catalyst design; active site engineering; single-atom catalysts; metal– organic frameworks; zeolites; nanostructured catalysts; in situ and operando characterizations; photocatalysis; electrocatalysis; biomass valorization; reaction engineering; renewable feedstocks

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Advances in Metastasis and Therapy: Targeting the Tumor Microenvironment

edited by

Ravi Thakur

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: cellular crosstalk; growth factors and cytokines; metastatic cascade; metabolic reprogramming; targeting tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Recent Research on Noble Metal Nanoparticles

edited by

Shinmori Hideyuki

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: nanostructure; gold nanoparticles; silver nanoparticles; heterometallic nanoparticles; core– shell structure; surface chemistry; colloid chemistry; localized surface plasmon resonance

(This special issue belongs to the Section Molecular Nanoscience)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Brain–Immune Crosstalk and Ischemic Injury

edited by

Yvonne Couch

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: stroke; ischemia; haemorrhage; inflammation; cytokines; macrophages; neutrophils; microglia; immunity

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Research on Taste Receptors

edited by

Ana R. Costa

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: taste receptors; taste signaling; gustatory system; molecular signaling; cellular mechanisms; health and disease; functional roles; neurobiology of taste; cancer biology and metastasis; translational research

(This special issue belongs to the Section Molecular Biology)

Tumor Organoids Uncovered: A Molecular Lens on Cancer Complexity

edited by Eleftherios Makris and

Konstantinos Ioannis Votanopoulos

submission deadline 28 Feb 2026 | Viewed by 74 | Submission Open

Keywords: tumor organoids; precision medicine; cancer modeling; drug screening; patient-derived models; molecular characterization; personalized therapy; translational research; biomarker discovery; clinical application

(This special issue belongs to the Section Molecular Oncology)

Molecular Basis of Proteinopathies in Neurodegenerative Diseases

edited by

Kyoung Joo Cho

submission deadline 28 Feb 2026 | Viewed by 74 | Submission Open

Keywords: protein misfolding; neurodegenerative diseases; protein aggregation; proteostasis; post-translational modifications; ubiquitin– proteasome system; autophagy; targeted protein degradation; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies

edited by

Giuseppe Mannino

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO

(This special issue belongs to the Section Molecular Plant Sciences)

Training Immunity and Reprogramming Monocytes and Macrophages in Health and Disease

edited by Eugenio A. Carrera Silva

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: monocytes; macrophage plasticity; regulatory reprogramming; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Latest Advances in Autoimmune and Inflammatory Rheumatic Diseases

edited by

Tanja Grubić-Kezele

submission deadline 28 Feb 2026 | Viewed by 72 | Submission Open

Keywords: autoimmune diseases; inflammatory diseases; rheumatic diseases; molecular mechanisms; pathogenesis; inflammation; central nervous system

(This special issue belongs to the Section Molecular Immunology)

Molecular Research of Cognitive Impairment and Neuropsychiatric Symptoms in Late Life: From Pathogenesis to Treatment

edited by

Ioannis Liampas

submission deadline 28 Feb 2026 | Viewed by 71 | Submission Open

Keywords: dementia; Alzheimer’ s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’ s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Machine Learning in RNA and Chromatin Dynamics

edited by Haopeng Yu

submission deadline 28 Feb 2026 | Viewed by 71 | Submission Open

Keywords: machine learning; chromatin architecture; RNA dynamics; genomic foundation models; computational biology

(This special issue belongs to the Section Molecular Biology)

Molecular Targeting and Pharmacology of Neuroinflammation

edited by

Lisa Lione

submission deadline 28 Feb 2026 | Viewed by 70 | Submission Open

Keywords: glia-targeted therapeutics; neuroinflammation; CNS drug development; astrocyte; microglia; neurodegeneration; translational neuroscience; biomarkers; human genetics; cytokine signaling

(This special issue belongs to the Section Molecular Neurobiology)

Cellular Senescence at the Crossroads: From Cancer Protection to Chronic Disease

edited by

Alexander Lang

submission deadline 28 Feb 2026 | Viewed by 70 | Submission Open

Keywords: cellular senescence; SASP (Senescence-associated secretory phenotype); senolytics; therapeutic targeting; biomarkers of senescence

(This special issue belongs to the Section Molecular Biology)

Biological Polyphenols in Cognitive Impairment-Related Diseases: Effects, Dosage and Molecular Mechanisms

edited by

Chunmei Li

submission deadline 28 Feb 2026 | Viewed by 69 | Submission Open

Keywords: natural polyphenols; cognitive impairment-related diseases; Alzheimer's disease; Parkinson's disease; depression; anxiety; lowest effective dose; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action

edited by

Piotr Dobrzynski

submission deadline 28 Feb 2026 | Viewed by 68 | Submission Open

Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers; loaded with silver ions; or antibiotics; antibacterial nano- and micro particles; anticoagulant layers

(This special issue belongs to the Section Materials Science)

Application of Metabolomics in Health and Human Diseases: Diagnostic, Therapeutic, Nutritional and Nutraceutical Perspectives

edited by

Barbara Tomasello

and Francesco Bellia

submission deadline 28 Feb 2026 | Viewed by 68 | Submission Open

Keywords: metabolomics; metabolomic profile biomarkers; preclinical studies; clinical studies; drug and nutraeuticals biological activities; precision medicine; personalized medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Future Perspective and Challenge of Nanomaterials

edited by

Antreas Afantitis

submission deadline 28 Feb 2026 | Viewed by 68 | Submission Open

Keywords: nanomaterial; nanoinformatics; materials informatics; functional material; molecular dynamics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Motor Mechanochemistry: Structure, Dynamics, and Function

edited by

Takeshi Sakamoto

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: molecular motors; kinesin; dynein; myosin; DNA helicase; cell motility; non-muscle myosin II; vesicle trafficking/transportation; single molecule imaging; force measurement; structure of cytoskeleton; ATP synthesis

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of SARS-CoV-2 Infection and Pathogenesis

edited by

Virginia Lotti

and

Erica Diani

submission deadline 28 Feb 2026 | Viewed by 65 | Submission Open

Keywords: SARS-CoV-2; molecular virology; host– pathogen interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cardio-Oncology: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Valentina Citi

submission deadline 28 Feb 2026 | Viewed by 62 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapies; cardiovascular complications; risk stratification; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Identification and Analysis of Interspecies Interactions in Microbial Biofilms

edited by

Terence L. Marsh

submission deadline 28 Feb 2026 | Viewed by 62 | Submission Open

Keywords: biofilm; interspecies communication; biofilm demographics; competition; commensalism; parasitism; mutualism; methodologies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Signatures for Risk Stratification and Therapeutic Decision-Making in Primary and Recurrent Prostate Cancer

edited by

Chengfei Liu

submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open

Keywords: molecular mechanisms; biomolecular research; mechanistic insights; molecular pathways; translational biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanomaterials in Tissue Engineering and Regenerative Medicine: Recent Advances and Future Prospects

edited by

Kapil D. Patel

submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open

Keywords: nanoparticles; nanofibers; nanotubes; nanocomposites; hydrogels; ceramics; bioactive glass nanoparticles; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Unveiling the Multifaceted Potential of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles

edited by

Bruno Solano de Freitas Souza

submission deadline 28 Feb 2026 | Viewed by 59 | Submission Open

Keywords: mesenchymal stem/stromal cells; extracellular vesicles; molecular mechanisms; preclinical and clinical studies; GMP manufacturing and scale-up

(This special issue belongs to the Section Molecular Biology)

Design and Application of Biocatalysts: Emerging Advances and Innovations in Enzyme Immobilization and Technologies

edited by

María Luján Ferreira

submission deadline 28 Feb 2026 | Viewed by 59 | Submission Open

Keywords: low-cost immobilization of enzymes; treatments post-immobilization; enzymatic synthesis of derivatives; polyesters depolymerization; hydroxy-acids polymerization; bioimprinting; post-immobilization treatments; composites

(This special issue belongs to the Section Biochemistry)

Molecular Research on Microglia in Neurodegenerative Diseases

edited by Bahareh Ajami

submission deadline 28 Feb 2026 | Viewed by 59 | Submission Open

Keywords: microglia; neuroinflammation; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; single-cell technologies; spatial profiling; glial biology; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Pancreatic Ductal Adenocarcinoma: Unveiling Pathogenic Mechanisms and Pioneering Novel Therapeutic Strategies

edited by

Elena Astanina

submission deadline 28 Feb 2026 | Viewed by 58 | Submission Open

Keywords: pancreatic ductal adenocarcinoma; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

The Pivotal Role of Endothelial Cells in Vascular Homeostasis and Immune Regulation

edited by

Ilenia Calcaterra

submission deadline 28 Feb 2026 | Viewed by 57 | Submission Open

Keywords: endothelial cells; vascular homeostasis; immune regulation; leukocyte trafficking; endothelial barrier function; mechanotransduction; glycocalyx; endothelial dysfunction; atherosclerosis; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Molecular Developments in the Diagnosis and Treatment of Cerebral Gliomas

edited by

Alejandro N. Santos

submission deadline 28 Feb 2026 | Viewed by 57 | Submission Open

Keywords: glioma; molecular profiling; liquid biopsy; radiogenomics; tumor microenvironment; immuno-therapy; targeted therapy; blood– brain barrier; biomarkers; precision oncology

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 28 Feb 2026 | Viewed by 55 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Glia: New Insights into Neurobiology and Therapeutic Potential

edited by María de los Ángeles García-Robles

submission deadline 28 Feb 2026 | Viewed by 55 | Submission Open

Keywords: glial metabolism; astrocytes; microglia; oligodendrocytes; tanycytes; obesity; diabetes; metabolic disorders; neurogenesis; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Interactions Between Nanoparticles and Biomolecules

edited by

Zhengwei Huang

submission deadline 28 Feb 2026 | Viewed by 54 | Submission Open

Keywords: nanoparticle– biomolecule interaction; nanomedicine; bio-corona; targeting; in vivo fate

(This special issue belongs to the Section Molecular Nanoscience)

Next-Generation Drug Development: Novel Modalities, AI Modeling, and Biomarkers

edited by

Chun-Yi Wu

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: pharmacokinetics; PK/PD modeling; biologics; antibody– drug conjugates (ADCs); biomarkers; artificial intelligence; novel therapeutic modalities; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Xenobiotic Toxicity: From Transcriptional Regulation to Reproductive and Behavioural Impacts

edited by Sylwia Swigonska

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: xenobiotic interactions; molecular mechanisms of toxicity; reproductive toxicology; early biomarkers; emerging contaminants; neurobehavioral toxicity; microbiota– xenobiotic interactions; biomolecular responses; environmental health; molecular toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Handshakes: Engineering Protein–Ligand Interfaces for Precision Drug Design

edited by Tarun Jairaj Narwani

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: structure-based drug design (SBDD); AI-driven drug discovery; protein– ligand dynamics; molecular interface engineering; structural biology; chemical biology; allosteric modulation; undruggable targets and drug resistance

(This special issue belongs to the Section Biochemistry)

Amino Acid and Sugar Metabolism in Disease

edited by V. Tkach

submission deadline 28 Feb 2026 | Viewed by 51 | Submission Open

Keywords: metabolic diseases; metabolic disturbances; carbohydrate metabolism; aminoacid metabolism; artificial sweeteners; metabolic path alterations

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Kidney Diseases: Molecular Pathogenesis and Therapeutic Strategies—3rd Edition

edited by