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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Structure and Function of Biological Molecules

edited by

Andrea Bernini

submission deadline 30 Jan 2027 | Viewed by 237 | Submission Open

Keywords: biological molecules; molecular structure; biomolecular function; structure–function relationships; molecular interactions; computational modeling; biophysical techniques

(This special issue belongs to the Section Molecular Biophysics)

Extracellular Vesicles in Tumor Growth and Progression

edited by

Josiah Ochieng

submission deadline 30 Jan 2027 | Viewed by 192 | Submission Open

Keywords: extracellular vesicles (EVs); tumor cells; secretion and uptake; metastasis; cancer biomarkers

(This special issue belongs to the Section Molecular Oncology)

Decoding the Exposome: Integrative Multi-Omics and Computational Toxicology for Precision Environmental Health

edited by

Ahsanullah Unar

submission deadline 30 Jan 2027 | Viewed by 191 | Submission Open

Keywords: exposome; multi-omics integration; computational toxicology; precision environmental health; environmental epigenomics; adverse outcome pathways; machine learning in toxicology; exposome-wide association studies; chemical risk assessment; systems toxicology

(This special issue belongs to the Section Molecular Informatics)

Chemical Biology Advance in Protein Conformational Diseases

edited by

Myriam M. Altamirano-Bustamante

and Nelly Altamirano-Bustamante

submission deadline 30 Jan 2027 | Viewed by 143 | Submission Open

Keywords: protein conformational diseases; misfolding and diseases; protein folding and diseases; amyloid proteins and diseases; diabetes; obesity; metabolic syndrome; Alzheimer diseases; cancer

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications—2nd Edition

edited by

Kota V. Ramana

submission deadline 30 Jan 2027 | Viewed by 126 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Prostate Cancer: Detection, Diagnosis and Treatment—a Contemporary Perspective

edited by

Mikhail Baryshev

submission deadline 30 Jan 2027 | Viewed by 106 | Submission Open

Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; noncoding genes; gene fusions; lncRNA

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Gut Microbiota–Host Interaction

edited by

Vincent C. Lombardi

submission deadline 30 Jan 2027 | Viewed by 94 | Submission Open

Keywords: gut microbiota; host interaction; molecular mechanisms; microbiota-derived signals; host signaling networks; mucosal immunity; gastrointestinal barrier integrity

(This special issue belongs to the Section Molecular Microbiology)

Oxidative Stress in Disease: From Biomarkers to Clinical Translation

edited by

Joško Osredkar

submission deadline 30 Jan 2027 | Viewed by 64 | Submission Open

Keywords: oxidative stress; disease biomarkers; redox regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Natural Products for Human Health and Disease

edited by

Rumyana Simeonova

submission deadline 31 Jan 2027 | 4 articles | Viewed by 20550 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section

edited by

Miklós Fried

and

Filippo Rossi

submission deadline 31 Jan 2027 | 15 articles | Viewed by 20457 | Submission Open

Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials

(This special issue belongs to the Section Materials Science)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 31 Jan 2027 | 6 articles | Viewed by 18231 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 31 Jan 2027 | 8 articles | Viewed by 17349 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Supplements and Drug-Based Strategies in Neonatal and Paediatric Health

edited by

Giulia Malaguarnera

submission deadline 31 Jan 2027 | 3 articles | Viewed by 13633 | Submission Open

Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota–host interactions; infectious diseases in children; neurodevelopmental disorders; drug–nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 31 Jan 2027 | 7 articles | Viewed by 13068 | Submission Open

Keywords: bacteria–host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Computational Approaches in Drug Discovery and Design: From Molecular Modeling to Translational Applications

edited by

Przemysław Czeleń

submission deadline 31 Jan 2027 | 6 articles | Viewed by 12488 | Submission Open

Keywords: computational drug discovery; molecular modeling; AI-driven drug design; molecular dynamics simulations; quantum chemistry; structure-based drug design; machine learning in pharmacology; virtual screening and docking; ADMET prediction; personalized medicine modeling

(This special issue belongs to the Section Molecular Informatics)

New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition

edited by

Federica Mannino

submission deadline 31 Jan 2027 | 6 articles | Viewed by 12165 | Submission Open

Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Psychedelics and Mental Disorders: From Molecular Mechanisms to Therapies Potential

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 31 Jan 2027 | 2 articles | Viewed by 11334 | Submission Open

Keywords: psychedelics; drug-induced neurotoxicity; therapeutic potential; mental disorders; neuroprotective mechanisms; adult neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 31 Jan 2027 | 6 articles | Viewed by 10943 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 31 Jan 2027 | 2 articles | Viewed by 9339 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 31 Jan 2027 | 6 articles | Viewed by 8932 | Submission Open

Keywords: biophysical chemistry; protein–protein interactions; protein–DNA interactions; protein–ligand interactions; receptor–ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2027 | 6 articles | Viewed by 8813 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Pathogen Interactions: 3rd Edition

edited by

Sixue Chen

submission deadline 31 Jan 2027 | 2 articles | Viewed by 8397 | Submission Open

Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential

edited by

Gregory Christodoulidis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 8050 | Submission Open

Keywords: natural compounds; cancer research; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap

edited by

Oliver Seifert

submission deadline 31 Jan 2027 | 3 articles | Viewed by 8003 | Submission Open

Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers

(This special issue belongs to the Section Molecular Biology)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jan 2027 | 1 articles | Viewed by 7499 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

edited by

Miriam Beatríz Virgolini

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7361 | Submission Open

Keywords: toxicity; adverse-outcome pathway; metals; pesticides; drugs of abuse; pharmaceuticals

(This special issue belongs to the Section Molecular Toxicology)

Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 31 Jan 2027 | 4 articles | Viewed by 7282 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Bioactive Compounds and Their Antioxidant Role: 2nd Edition

edited by Tamara Jurina

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7270 | Submission Open

Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 31 Jan 2027 | 5 articles | Viewed by 7265 | Submission Open

Keywords: maternal–fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Natural Products and Drug Delivery Systems in Dental Diseases

edited by

Rafael Scaf De Molon

submission deadline 31 Jan 2027 | 3 articles | Viewed by 7185 | Submission Open

Keywords: periodontitis; natural products; anti-inflammatory therapy; local drug delivery; gingival inflammation; regenerative periodontics; nanotechnology in dentistry; herbal medicine; antimicrobial agents; oral microbiome modulation; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Pathology and Treatment of Breast Cancer

edited by

Nabil Ismaili

submission deadline 31 Jan 2027 | 2 articles | Viewed by 7185 | Submission Open

Keywords: breast cancer; molecular pathology; precision medicine; antibody-drug conjugates (ADCs); circulating tumor DNA (ctDNA); targeted therapy; immunotherapy; treatment resistance; oligometastatic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 31 Jan 2027 | 4 articles | Viewed by 7039 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Research on System Biology Methods and Tools for Integrating Omics Data

edited by Yuanyan Xiong

submission deadline 31 Jan 2027 | 4 articles | Viewed by 7001 | Submission Open

Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Steroids in Human Disease and Health

edited by

Martin Hill

submission deadline 31 Jan 2027 | 6 articles | Viewed by 6921 | Submission Open

Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 31 Jan 2027 | 3 articles | Viewed by 6884 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant–pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products

edited by Emira D’Amico

submission deadline 31 Jan 2027 | 8 articles | Viewed by 6558 | Submission Open

Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals

(This special issue belongs to the Section Molecular Biology)

mRNA/miRNAs Network in Diabetes and Its Complications

edited by

Daniela Lixandru

submission deadline 31 Jan 2027 | 2 articles | Viewed by 6146 | Submission Open

Keywords: RNA/miRNAs; exosomes; regenerative medicine; translational medicine; adipose tissue biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Non-Coding RNAs’ Functionality—Diagnosis and Therapy in Cancer and Other Indications (2nd Edition)

edited by

Mohamed Raafat El-Gewely

submission deadline 31 Jan 2027 | 3 articles | Viewed by 6099 | Submission Open

Keywords: non-coding RNAs (ncRNAs); long non-coding RNAs (lncRNAs); MicroRNAs (miRNAs); circular RNAs (circRNAs); epigenetic and post-transcriptional regulation; epithelial–mesenchymal transition (EMT); cell proliferation and Apoptosis; biomarkers and Liquid biopsy; RNA-based therapeutics; next-generation sequencing (NGS); CRISPR/Cas9 screening; single-cell RNA sequencing (scRNA-seq); RNA interference (RNAi); cancer stem cells; early cancer diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Retinal Diseases: 3rd Edition

edited by Minzhong Yu

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5947 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MHELTHERA: Targeted Molecular Radio-Immuno-Theranostics in Cancer and Beyond—in Honor of Prof. Dr. Otmar Dieter Wiestler

edited by Michael Philipp Bachmann and Holger Stephan

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5698 | Submission Open

Keywords: molecular diagnostics; radiotherapy; immunotherapy; endoradionuclide therapy; radiodiagnostics; radio-immuno-theranostics; radionuclides; PET/SPECT imaging; nanomaterials; chelators; chimeric antigen receptors (CARs); adapter CAR T cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Venom and Antivenom

edited by

Vance G. Nielsen

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5643 | Submission Open

Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction

(This special issue belongs to the Section Molecular Toxicology)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5634 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5517 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Primary Colorectal Cancer and Liver Metastases

edited by Alexandros E. Giakoustidis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5412 | Submission Open

Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5347 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition

edited by

Michael Eccles

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5322 | Submission Open

Keywords: melanoma; pathology; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies (2nd Edition)

edited by

Snježana Kaštelan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5285 | Submission Open

Keywords: eye disease; immunobiological features; molecular pathogenesis; biomarkers; clinical implications; emerging therapies; lacrimal gland; ocular tumors; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5084 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Cancer-Associated Stromal Cells

edited by Krisztián Németh and Balazs Mayer

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5079 | Submission Open

Keywords: cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules

(This special issue belongs to the Section Molecular Oncology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5042 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine, decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2051-2100 on page 42 of 62.

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