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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications

edited by Maria Rosaria Tumolo and Saverio Sabina

submission deadline 30 Nov 2026 | 7 articles | Viewed by 6020 | Submission Open

Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches

(This special issue belongs to the Section Molecular Informatics)

Advances in Next-Generation CRISPR and Gene Editing Tools

edited by

Oscar Pérez-Leal

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5829 | Submission Open

Keywords: CRISPR engineering; miniaturized CRISPR; gene editing delivery; prime editing; base editing; epigenome editing; single-cell CRISPR

(This special issue belongs to the Section Molecular Genetics and Genomics)

AI, ML and Bioinformatics in Molecular Mechanisms of Human Health and Disease

edited by

Santosh Anand

submission deadline 30 Nov 2026 | 8 articles | Viewed by 5808 | Submission Open

Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers

(This special issue belongs to the Section Molecular Informatics)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5806 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5672 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Emerging Insights into the Pathobiology and Biomarkers of Traumatic Brain Injury (TBI)

edited by Jessica Gill

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5634 | Submission Open

Keywords: traumatic brain injury (TBI); blood-based biomarkers; neuroinflammation; axonal injury; neurodegeneration; precision medicine; omics approaches (genomics, proteomics, metabolomics); translational neuroscience; TBI recovery and outcomes; neurovascular injury

(This special issue belongs to the Section Molecular Neurobiology)

Biomarker Discovery in Oral Diseases: Integrating Connected Health and Digital Biomarkers for Advanced Diagnostics and Personalized Care

edited by

Shahnawaz Khijmatgar

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5590 | Submission Open

Keywords: oral diseases; biomarker; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

New Insights into Lactoferrin: 2nd Edition

edited by

Antimo Cutone

and

Giovanni Musci

submission deadline 30 Nov 2026 | 4 articles | Viewed by 5590 | Submission Open

Keywords: lactoferrin; lactoferrin structure; lactoferrin functions; infection; inflammation; iron homeostasis; oxidative stress; lactoferrin bioavailability

(This special issue belongs to the Section Molecular Immunology)

Cardiovascular Diseases: Histopathological and Molecular Diagnostics, 2nd Edition

edited by

Simona Gurzu

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5481 | Submission Open

Keywords: cardiovascular disorders; heart failure; aortic diseases; cardiomyocytes; cardiac function; myocarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Women’s Health: Advances in Gynecological Disease Mechanisms and Therapeutics

edited by

Tsung-Hsuan Lai

submission deadline 30 Nov 2026 | 6 articles | Viewed by 5454 | Submission Open

Keywords: ART and IVF; prenatal diagnosis; infertility; minimally invasive surgery; robotic surgery; PCOS; endometriosis; menopause; AI

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Novel Therapeutic Strategies for Cancers

edited by

Emanuela Grassilli

and

Maria Grazia Cerrito

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5391 | Submission Open

Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Mechanisms in Inflammatory Bowel Disease

edited by Michael Bording-Jorgensen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5314 | Submission Open

Keywords: IBD; cytokines; microbiome; Crohn’s disease; ulcerative colitis; dysbiosis; mucosal immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy

edited by

Furong Tian

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5252 | Submission Open

Keywords: neurodegenerative diseases; brain cancer; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Lung Research: From Mechanisms to Therapeutic Innovation

edited by

Johnatas D Silva

and Fernanda Ferreira Cruz

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5234 | Submission Open

Keywords: lung disease; molecular mechanisms; lung injury and repair; regeneration; biomarkers; therapeutic innovation; translational research; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Molecular Research on Pregnancy Complication Mechanisms

edited by

Aleksandra Stefanović

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5214 | Submission Open

Keywords: hypertensive pregnancy disorders; gestational diabetes; intrauterine growth restriction; maternal metabolism in pregnancy complications; genetic and epigenetic mechanisms in pregnancy complications; immunology in pregnancy complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5107 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases

edited by

Mohammed Jakaria

and

Jason Cannon

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5079 | Submission Open

Keywords: neurotoxicity; cellular stress; neuronal cell death; ferroptosis; neurodegeneration; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Translational Research in Cardiovascular Endocrinology, Cardiovascular–Kidney–Metabolic Diseases and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): 3rd Edition

edited by

Eva Kassi

Ioannis Kyrou

and

Harpal S. Randeva

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5037 | Submission Open

Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4973 | Submission Open

Keywords: rare diseases; genotype–phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic and Post-Transcriptional Regulation of Gene Expression

edited by

Lidia Borkiewicz

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4820 | Submission Open

Keywords: epigenome; DNA methylation; chromatin remodeling; histone modifications; non-coding RNA; epitranscriptome; alternative splicing; RNA methylation; RNA edition

(This special issue belongs to the Section Molecular Biology)

Current Research in Membrane Transporters, Channels, and Receptors

edited by

Ivana Vrhovac Madunic

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4744 | Submission Open

Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by

Natalia Nowacka-Jechalke

and

Marta Kinga Lemieszek

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4634 | Submission Open

Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure–activity relationship; anticancer potential; immunomodulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Purinergic System

edited by

Margarete Dulce Bagatini

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4581 | Submission Open

Keywords: purinergic system; receptors; ectonucleotidases; CD39; CD73; purinergic signaling

(This special issue belongs to the Section Biochemistry)

Circulating Biomarkers for the Diagnosis of Cancer

edited by Fernando Luiz Affonso Fonseca

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4563 | Submission Open

Keywords: biomarkers; circulating ; lab methods; diagnosis; screening

(This special issue belongs to the Section Molecular Oncology)

Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models

edited by Eugenio Alladio and

Elena Pilli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4525 | Submission Open

Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition

edited by Sanja Dabelić

submission deadline 30 Nov 2026 | 4 articles | Viewed by 4510 | Submission Open

Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics

(This special issue belongs to the Section Macromolecules)

Bridging Molecules and Reactions: Next-Generation Approaches for Advancing Electrocatalytic Efficiency

edited by

Abu Talha Aqueel Ahmed

submission deadline 30 Nov 2026 | 1 articles | Viewed by 4481 | Submission Open

Keywords: electrochemical nanomaterials; energy storage and conversion; electrocatalysis and reaction mechanisms; photoelectrochemical water splitting; electrochemical energy storage devices; nanocomposites and functionalized materials; molecular-level electrocatalysis; electrocatalyst and photocatalysts; in-situ spectroscopy and atomistic modeling; hybrid molecular–nanostructured systems; sustainable and natural resource–derived materials; DFT related to reaction kinetics; AOP

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms

edited by

Laura Georgiana Necula

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4475 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostic; targeted therapy; biomarkers; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4470 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Pathology and Next-Generation Biomarkers in Nephrology

edited by

Marijn Speeckaert

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4452 | Submission Open

Keywords: nephrology; genetic mutations; epigenetics; next-generation biomarkers; proteomics; metabolomics; single-cell sequencing; spatial transcriptomics; liquid biopsy; cfDNA; exosomes; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Biology to Biomechanics: Molecular Advances in Orthodontic Remodeling and Acceleration

edited by

Marcin Derwich

and

Alessandra Lucchese

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4378 | Submission Open

Keywords: orthodontic tooth movement; bone remodeling; root resorption; molecular mechanisms; inflammatory response; corticotomy-assisted orthodontics; biomechanics; periodontal ligament; cellular signaling; accelerated orthodontic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

G Protein-Coupled Receptor Signaling and Regulation, 2nd Edition

edited by

Vsevolod V. Gurevich

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4170 | Submission Open

Keywords: GPCRs; signaling; trafficking; G proteins; arrestins; RGS proteins; GRKs

(This special issue belongs to the Section Biochemistry)

Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment—2nd Edition

edited by

Morris Karmazyn

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4031 | Submission Open

Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Crop Quality

edited by

Jinsong Bao

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4030 | Submission Open

Keywords: crop quality; molecular breeding; multi-omics; gene editing; precision agriculture; functional genomics; rice; wheat; maize; barley; sorghum; millet; potato; cotton; molecular markers; genome-wide association studies; genome editing; genome selection; molecular selection; transcriptomics; omics; post-translational regulation; starch; protein; lipids; vitamin; processing quality; eating quality

(This special issue belongs to the Section Molecular Plant Sciences)

Hemolytic Anemia: From Molecular Mechanisms to Therapeutic Exploitation

edited by Joan-Lluis Vives-Corrons

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3961 | Submission Open

Keywords: hemolytic anemias; red blood cells; sickle cell disease; targeted therapies; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Ataxia

edited by

Jose Miguel Laffita-Mesa

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3912 | Submission Open

Keywords: ataxia; molecular mechanisms; repeat expansion disorders; gene discovery; biomarkers; RNA biology; protein aggregation; epigenetics; gene therapy; neurodegeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 30 Nov 2026 | 1 articles | Viewed by 3842 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene–environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Vector-Mediated Genome Editing Therapy

edited by

Izumu Saito

submission deadline 30 Nov 2026 | 1 articles | Viewed by 3832 | Submission Open

Keywords: CRISPR; genome editing; base editing; AAV vector; adenovirus vector; lentivirus vector; viral vectors; inherited disease; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Application of Germplasm Innovation Technology in Aquatic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3784 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Artificial Intelligence, Multi-Omics, and Molecular Modelling in Modern Drug Discovery

edited by

Shaban Ahmad

submission deadline 30 Nov 2026 | Viewed by 3776 | Submission Open

Keywords: artificial intelligence (AI); machine learning; multi-omics integration; molecular modelling; computational drug discovery; virtual screening; generative AI; explainable AI (XAI); ADMET prediction; pharmacogenomics; systems biology

(This special issue belongs to the Section Molecular Pharmacology)

Environmental Influences on Cellular Responses

edited by

Marcus Krüger

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3766 | Submission Open

Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction

(This special issue belongs to the Section Molecular Biology)

Genomic, Transcriptomic, and Epigenetic Approaches in Fish Research

edited by

Feng Liu

submission deadline 30 Nov 2026 | 5 articles | Viewed by 3720 | Submission Open

Keywords: fish biology; omics technologies; genomics and transcriptomics; environmental adaptation; aquaculture traits

(This special issue belongs to the Section Molecular Biology)

Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine

edited by

Mariapaola Marino

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3649 | Submission Open

Keywords: innate immunity; adaptive immunity; inflammation; autoantibodies; peptides; cytokines; receptors; leukocytes; extracellular vesicles; signal transduction; apoptosis

(This special issue belongs to the Section Molecular Immunology)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3516 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular Research on Renal Disease

edited by Niels Henrik Buus and Marco Eijken

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3404 | Submission Open

Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Plant Breeding

edited by

Hélia Cardoso

, Sandra Correia and

Isaura Castro

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3332 | Submission Open

Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Extracellular Vesicles in Disease and Therapeutic Applications

edited by Sunyoung Park

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3263 | Submission Open

Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by

Daniel P. Potaczek

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3198 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Macroporous, Mesoporous, and Microporous Materials

edited by

Magdalena Laskowska

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3131 | Submission Open

Keywords: functional materials; nanomaterials; nanostructures; molecular systems; porous materials

(This special issue belongs to the Section Materials Science)

Natural Products as Therapeutic Agents: From Molecular Targets to Cellular and Functional Modulation

edited by Su-Yun Lyu

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2999 | Submission Open

Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1451-1500 on page 30 of 64.

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