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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Primary Colorectal Cancer and Liver Metastases

edited by Alexandros E. Giakoustidis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5334 | Submission Open

Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies (2nd Edition)

edited by

Snježana Kaštelan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5153 | Submission Open

Keywords: eye disease; immunobiological features; molecular pathogenesis; biomarkers; clinical implications; emerging therapies; lacrimal gland; ocular tumors; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5135 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition

edited by

Michael Eccles

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5105 | Submission Open

Keywords: melanoma; pathology; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5063 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Cancer-Associated Stromal Cells

edited by Krisztián Németh and Balazs Mayer

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4927 | Submission Open

Keywords: cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules

(This special issue belongs to the Section Molecular Oncology)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4908 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4877 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine, decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4816 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus–host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

The Role of Gut Microbiome Regulation in Immunity and Inflammation

edited by Lei Deng

submission deadline 31 Jan 2027 | 5 articles | Viewed by 4734 | Submission Open

Keywords: gut microbiome; adaptive immunity; IBD; inflammation; innate immunity; enteric infections; salmonella; intestine barrier; mucosal immunity

(This special issue belongs to the Section Molecular Microbiology)

MHELTHERA: Targeted Molecular Radio-Immuno-Theranostics in Cancer and Beyond—in Honor of Prof. Dr. Otmar Dieter Wiestler

edited by Michael Philipp Bachmann and Holger Stephan

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4719 | Submission Open

Keywords: molecular diagnostics; radiotherapy; immunotherapy; endoradionuclide therapy; radiodiagnostics; radio-immuno-theranostics; radionuclides; PET/SPECT imaging; nanomaterials; chelators; chimeric antigen receptors (CARs); adapter CAR T cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Cancer Metabolism: From Mechanism to Therapies

edited by

Zisis Kozlakidis

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4495 | Submission Open

Keywords: cancer metabolism; metabolic alterations; Warburg effect; metabolic reprogramming; metabolic disorder; mitochondrial dysfunction; mitochondrial dynamics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Strategies and Molecular Insights Into Wound Healing

edited by

Cheong Hoon Seo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4312 | Submission Open

Keywords: wound healing; tissue regeneration; hypertrophic scar; biomaterials; stem cell therapy; gene therapy; exosomes; burn rehabilitation; inflammation; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Strategies Targeting Solid Tumors and the Tumor Microenvironment

edited by Emanuela Berrino and

Giuseppina Catanzaro

submission deadline 31 Jan 2027 | 4 articles | Viewed by 4134 | Submission Open

Keywords: cancer; tumor microenvironment; medicinal chemistry; drug design; structure–activity relationships; nanotechnologies; antibody–drug conjugates; non-coding RNAs; epigenetic

(This special issue belongs to the Section Molecular Oncology)

Cell Death in Human Diseases: Mechanisms, Biomarkers and Therapeutic Opportunities

edited by

Decha Pinkaew

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4103 | Submission Open

Keywords: cell death; apoptosis; necroptosis; ferroptosis; pyroptosis; human disease; biomarkers

(This special issue belongs to the Section Molecular Biology)

Endometriosis: Current Trends and Research Developments

edited by

Sylvia Mechsner

and

Renata Voltolini Velho

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4014 | Submission Open

Keywords: endometriosis; molecular mechanisms; pathophysiology; hormonal regulation; immune response; epigenetics; inflammation; biomarkers; transcriptomics; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Current Progress in Neutrophil Extracellular Traps (NETs)

edited by

Joanna Czerwińska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 4004 | Submission Open

Keywords: PAD4; NETs; autoimmune diseases; CECNs; autoantibodies

(This special issue belongs to the Section Molecular Immunology)

Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment

edited by

Mirjana Jerkic

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3952 | Submission Open

Keywords: mesenchymal stem/stromal cells (MSCs); MSC homing; MSC properties; immune cells; macrophages; injury; inflammation; cell therapy

(This special issue belongs to the Section Molecular Immunology)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3887 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Alzheimer’s Disease

edited by

Giulia Bivona

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3881 | Submission Open

Keywords: Alzheimer’s Disease; amyloid beta; molecular target

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Peptide Drugs for Metabolic Diseases

edited by

Lukasz Buldak

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3779 | Submission Open

Keywords: metabolic disorders; peptide drugs; MASLD; receptor targeting; lipid regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

DNA, Chromatin and Genome Structure

edited by Myakishev-Rempel Max and

Alexandre Vetcher

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3686 | Submission Open

Keywords: DNA structure and dynamics; non-B DNA structures (G-quadruplexes, Z-DNA); DNA topology; R-loops; RNA-DNA triplexes; extrachromosomal DNA (eccDNA); chromatin conformation (Hi-C, Micro-C, 3C); chromatin compaction; TADs and chromatin loops; three-dimensional genome organization; transcription regulation; gene regulation; DNA replication; DNA repair; transposable elements; chromosomal rearrangements; epigenetics; molecular modeling of DNA; molecular modeling of DNA hydration; molecular modeling of chromatin; telomeres; centromeres; introns; noncoding DNA

(This special issue belongs to the Section Molecular Biology)

Brain Stroke Across the Lifespan: Mechanisms, Models, Translational Advances and Impacts Beyond the Brain

edited by

Gabriele Deidda

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3556 | Submission Open

Keywords: stroke; brain; cerebral injury; post-stroke recovery; systemic physiology; models; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Venom Research

edited by Juliana Pavan Zuliani

submission deadline 31 Jan 2027 | 1 articles | Viewed by 3548 | Submission Open

Keywords: venoms; toxins; biological activities; therapeutic potential; molecular mechanism; venomous animals; pharmacological effects

(This special issue belongs to the Section Molecular Toxicology)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3504 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Responses to Microorganisms and Insects

edited by

Sumit Jangra

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3343 | Submission Open

Keywords: biotic stresses; crop protection; signaling molecules; transcriptomics; proteomics; microRNAs; resistance mechanism; plant–microbe–vector interactions

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Thrombosis: 4th Edition

edited by

Isabella Russo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3317 | Submission Open

Keywords: thrombosis; platelets; coagulation; diabetes; obesity; insulin resistance; metabolic disease; cardiovascular diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurofibromatosis Type 1 and NF2-Related Schwannomatosis: Advances from Basic Research to Current Therapies

edited by

Bumjoon Park

and

Baehoon Kim

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3278 | Submission Open

Keywords: neurofibromatosis type 1 (NF1); neurofibromin; RAS/MAPK pathway; malignant peripheral nerve sheath tumor (MPNST); NF2-related schwannomatosis (NF2 syndrome); Merlin (Schwannomin); vestibular schwannoma; meningioma; ependymoma

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Neurorepair and Regeneration

edited by

Andrei Gresita

and Tiago Santos

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3266 | Submission Open

Keywords: neurorepair; regeneration; neuroplasticity; cellular reprogramming; biomaterials; stroke; spinal cord injury; traumatic brain injury; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Crosstalk in Allergy, Barrier Dysfunction, and Asthma

edited by

Elisa Boni

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3208 | Submission Open

Keywords: barrier dysfunction; asthma; allergy; molecular pathways; molecular crosstalks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breast Cancer: From Pathophysiology to Novel Therapies, 2nd Edition

edited by Jennifer Sims-Mourtada

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3132 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Determinants of Neuromotor Control, Tremor, and Fatigue

edited by

Szymon Kulis

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3122 | Submission Open

Keywords: neuromuscular control; physiological tremor; muscle fatigue; sensorimotor integration; motor unit physiology; muscle oscillations; neuromuscular adaptation; excitation–contraction coupling; fatigue biomarkers; neurophysiology of movement

(This special issue belongs to the Section Molecular Neurobiology)

Analyzing the Molecular Mechanisms of Plant Disease Pathogenesis and Host Disease Resistance

edited by Zhibing Wu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3094 | Submission Open

Keywords: pathogenicity mechanisms; plant–pathogen interactions; plant immunity; effector biology; resistance genes; multi-omics approaches; nanotechnology in plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury

edited by Beatriz Martín-Carro

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3087 | Submission Open

Keywords: cardiovascular disease; myocardial injury; heart failure; biomarkers; risk stratification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breakthroughs in Anti-Cancer Agents Discovery

edited by

Giulia Bononi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3085 | Submission Open

Keywords: medicinal chemistry; drug discovery; cancer; anti-cancer agents; synthesis; bioactive molecules; biological evaluation; computational drug discovery; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Regulation of Brown Adipose Function

edited by

Stephen F. Vatner

and

Shinsuke Nirengi

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3069 | Submission Open

Keywords: brown adipose tissue; metabolic disorders; thermogenesis; endocrine function; cellular signaling

(This special issue belongs to the Section Biochemistry)

Novel Biomarkers and Treatment Strategies for Parkinson’s Disease

edited by Aron Emmi

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3037 | Submission Open

Keywords: Parkinson’s Disease; alpha-synuclein; disease-modifying therapy; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2938 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2934 | Submission Open

Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Treatment in Gastrointestinal Cancers

edited by

Dani Ran Castillo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2806 | Submission Open

Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Structure and Its Interactions

edited by

Dong Hae Shin

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2797 | Submission Open

Keywords: protein–protein interactions (PPIs); protein–ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis

(This special issue belongs to the Section Molecular Biology)

Advanced Functional Materials for Catalysis and Storage

edited by

Kaixin Zhu

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2788 | Submission Open

Keywords: functional materials; energy catalysis; small molecule conversion; energy storage

(This special issue belongs to the Section Materials Science)

Recombinant Proteins and Antibody Engineering for Diagnostic and Treatment of Emerging Infectious Diseases

edited by

Gustavo Helguera

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2722 | Submission Open

Keywords: recombinant proteins; antibody engineering; monoclonal antibodies; hemorrhagic fevers; tuberculosis; emerging infectious diseases; neglected viruses; diagnostics; therapeutic antibodies

(This special issue belongs to the Section Molecular Immunology)

Synthesis, Characterization and Applications of Advanced Polymer Materials

edited by Namil Kim

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2647 | Submission Open

Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications

(This special issue belongs to the Section Macromolecules)

RNA in Biology and Medicine (2nd Edition)

edited by

Roberto Patarca

and William A. Haseltine

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2643 | Submission Open

Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function

(This special issue belongs to the Section Molecular Biology)

Molecular Perspectives in Lung Diseases: Pathogenesis, Diagnosis, and Treatment—2nd Edition

edited by

Elena Levantini

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2629 | Submission Open

Keywords: lung cancer models; cancer stem cells; tumor microenvironment; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pharmacological Effects of Bioactive Compounds Derived from Plants

edited by

Ibrahim Mssillou

submission deadline 31 Jan 2027 | 4 articles | Viewed by 2612 | Submission Open

Keywords: bioactive compounds; wound healing; anti-cancer; anti-inflammatory; mechanism of action; antioxidants; neuroprotection; pharmacological properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Systemic Lupus: Molecular Research, New Biomarkers and Novel Therapy

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2588 | Submission Open

Keywords: lupus; biomarkers; autoimmunity; inflammation; therapy; treatment; endocrine; prolactin; stress; T cell and B cell activation; T cell and B cell proliferation; antigenic immunosuppression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electromagnetic Field Interactions with Biomolecules

edited by

Svetlana Jovanović

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2545 | Submission Open

Keywords: nonionizing electromagnetic fields; biomolecules; proteins; oxidative stress; Fe metabolism; amyloid-β peptide

(This special issue belongs to the Section Materials Science)

Cellular Memory in Response to Environmental Conditions

edited by

Satoshi Kishigami

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2474 | Submission Open

Keywords: cellular memory; cellular environment; embryonic development; epigenetics; transgenerational inheritance; mammals; DOHaD

(This special issue belongs to the Section Molecular Biology)

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