Novel Biomarkers and Treatment Strategies for Parkinson’s Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 13
Special Issue Editor
Special Issue Information
Dear Colleagues,
Parkinson’s disease (PD) is the fastest-growing neurological disorder worldwide and remains a major clinical and societal challenge. Its management is complicated by progressive disability, levodopa-resistant symptoms, and treatment-related complications. Key priorities include slowing disease progression through the integration of sensitive biomarkers, early diagnostic tools, and targeted biological therapies. On the other hand, efforts toward disease modification face challenges due to the complex and multifaceted pathophysiology of PD; yet, promising approaches are emerging, including interventions targeting α-synuclein aggregation and pathways implicated in genetic forms of the disease. Equally important is the refinement of symptomatic treatments—ranging from pharmacological to surgical and infusion-based therapies—with a focus on addressing levodopa-resistant symptoms and improving quality of life.
This Special Issue welcomes contributions on disease-modifying strategies, biomarker discovery, clinical-trial design and endpoints, digital and technological innovations for disease monitoring, and the development of novel symptomatic treatments. By uniting diverse perspectives across basic, translational, and clinical research, this collection aims to advance the understanding and management of PD and accelerate progress toward meaningful therapeutic breakthroughs.
Dr. Aron Emmi
Guest Editor
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Keywords
- Parkinson’s Disease
- alpha-synuclein
- disease-modifying therapy
- biomarkers
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