Protein Structure and Its Interactions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 15
Special Issue Editor
Interests: crystal structure; proteins; protein structure; X-ray diffraction; protein-protein interaction; protein expression; protein characterization
Special Issue Information
Dear Colleagues,
Understanding protein structure and its molecular interactions is fundamental to advancing modern biology and medicine. High-resolution structural techniques such as cryo-electron microscopy, X-ray crystallography, and NMR spectroscopy have enabled unprecedented insights into the dynamic architecture of proteins and their functional assemblies. Recent developments in AI-based protein structure prediction, such as AlphaFold and RoseTTAFold, have further accelerated discovery in structural biology, revealing novel interfaces and previously uncharacterized complexes. This Special Issue welcomes original research and reviews focused on the structural basis of protein–protein, protein–ligand, and protein–nucleic acid interactions. Topics may include structural dynamics, allosteric regulation, computational modeling, drug-target interactions, and mechanisms of molecular recognition. Studies integrating experimental and computational approaches are particularly encouraged. This Special Issue aims to showcase cutting-edge discoveries that deepen our understanding of protein structure-function relationships and their implications for disease mechanisms and therapeutic development.
Prof. Dr. Dong Hae Shin
Guest Editor
Manuscript Submission Information
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Keywords
- protein–protein interactions (PPIs)
- protein–ligand binding
- molecular recognition
- binding affinity and specificity
- molecular interface analysis
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