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Pharmacological Effects of Bioactive Compounds Derived from Plants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1210

Special Issue Editor


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Guest Editor
Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco
Interests: plants-derived compounds; medicinal plants; plant extracts; pharmacological effects; wound healing; inflammation; cancer; natural products; analytical chemistry

Special Issue Information

Dear Colleagues,

Plant-derived compounds exert a wide range of biological and pharmacological effects that contribute significantly to human health. These natural bioactive molecules have been shown to reduce inflammation, promote wound healing, exhibit anticancer activity, possess notable antimicrobial properties, and play a protective role against neuronal degeneration.

Despite the wide range of beneficial properties attributed to plant-derived compounds, these activities require further scientific attention and rigorous evaluation. Comprehensive investigation is necessary to identify and characterize new bioactive compounds and to assess their efficacy and mechanisms of action using diverse pharmacological models.

This Special Issue, entitled “Pharmacological Effects of Bioactive Compounds Derived from Plants”, welcomes the submission of original research articles and reviews involving in vitro and in vivo pharmacological effects of natural bioactive compounds from plants, including their possible application in wound healing, cancer treatment, as well as their anti-inflammatory and antimicrobial effects.

I look forward to receiving your contributions.

Dr. Ibrahim Mssillou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Keywords

  • bioactive compounds
  • wound healing
  • anti-cancer
  • anti-inflammatory
  • mechanism of action
  • antioxidants
  • neuroprotection
  • pharmacological properties

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Published Papers (2 papers)

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Research

23 pages, 22399 KB  
Article
N-p-trans-Coumaroyltyramine Improves Myocardial Ischemia–Reperfusion Injury: From Cellular Protection to Animal Model Validation and the Discovery of the Target Tcap
by Xiangyun Chen, Yuxin Lu, Yunfang Kou, Mengyue Guo and Yaofeng Li
Int. J. Mol. Sci. 2026, 27(8), 3523; https://doi.org/10.3390/ijms27083523 - 15 Apr 2026
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Abstract
Myocardial ischemia–reperfusion injury (MIRI) significantly limits the clinical benefits of reperfusion therapy, underscoring a pressing need for effective interventions. This study examines the cardioprotective effects and underlying mechanisms of the natural amide alkaloid N-p-trans-Coumaroyltyramine (p-CT). Using hypoxia/reoxygenation (H/R) models [...] Read more.
Myocardial ischemia–reperfusion injury (MIRI) significantly limits the clinical benefits of reperfusion therapy, underscoring a pressing need for effective interventions. This study examines the cardioprotective effects and underlying mechanisms of the natural amide alkaloid N-p-trans-Coumaroyltyramine (p-CT). Using hypoxia/reoxygenation (H/R) models in neonatal rat cardiomyocytes and in vivo rat MIRI models, we assessed p-CT pretreatment on cell viability, cardiac function, serum injury markers (lactate dehydrogenase, creatine kinase-MB, cardiac troponin T, and myoglobin), myocardial histopathology, ultrastructural alterations, and infarct size. The systematic screening and validation of potential targets were conducted via label-free quantitative proteomics, molecular docking, and Western blot. The results demonstrated that p-CT pretreatment dose-dependently mitigated H/R-induced cellular injury, improved cardiac function in MIRI rats, reduced serum markers of myocardial damage, alleviated pathological and ultrastructural injury in myocardial tissue, and significantly diminished infarct size. Proteomic analysis revealed 19 differentially expressed proteins specifically reversed by p-CT, with Titin-cap (Tcap) exhibiting the most pronounced downregulation in the MIRI model—a change effectively restored by p-CT pretreatment. Molecular docking indicated strong binding affinity between p-CT and Tcap protein. In summary, p-CT represents a promising cardioprotective agent, likely exerting its effects by targeting Tcap protein and upregulating its expression, thereby helping preserve cardiomyocyte structural and functional integrity. Full article
(This article belongs to the Special Issue Pharmacological Effects of Bioactive Compounds Derived from Plants)
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18 pages, 1249 KB  
Article
Effects of Passiflora edulis Leaf Extract on Lipid Accumulation in HepG2 Cells: In Vitro Evidence and Molecular Docking Analysis Involving PPARα and SREBP-1
by Johanny Aguillón Osma, John Sebastián León Villarreal and Nelsy Loango Chamorro
Int. J. Mol. Sci. 2026, 27(7), 3003; https://doi.org/10.3390/ijms27073003 - 26 Mar 2026
Viewed by 463
Abstract
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid accumulation and represents a major global health concern. Passiflora edulis contains numerous phytochemicals associated with diverse biological activities, including hepatoprotective and hypolipidemic effects. This study evaluated the effects of the ethanolic extract [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid accumulation and represents a major global health concern. Passiflora edulis contains numerous phytochemicals associated with diverse biological activities, including hepatoprotective and hypolipidemic effects. This study evaluated the effects of the ethanolic extract of P. edulis leaves on lipid accumulation in a cellular model of NAFLD, as well as its potential effect on transcriptional factors involved in lipid metabolism. HepG2 cells were exposed to steatogenic conditions and treated with the extract at non-cytotoxic concentrations, quantifying intracellular and extracellular triglycerides and cholesterol levels. Additionally, molecular docking analyses were performed to evaluate the interaction of reported P. edulis phytochemicals with PPARα and SREBP-1. The results revealed a significant reduction in intracellular lipid content compared to untreated cells, while molecular docking predicted favorable binding interactions between the bioactive compounds in the extract, with higher predicted affinity for PPARα (agonist-like interaction) than for SREBP-1c (antagonist-like interaction). These findings suggest that compounds from P. edulis leaves reduce lipid accumulation in liver cells and provide preliminary evidence supporting possible interactions with lipid-regulating transcription factors. Full article
(This article belongs to the Special Issue Pharmacological Effects of Bioactive Compounds Derived from Plants)
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