Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2026
Special Issue Editor
2. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: cardiovascular diseases; chronic kidney disease; mortality; biomarker
Special Issue Information
Dear Colleagues,
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide and continue to pose a major challenge for healthcare systems. Despite advances in diagnosis and therapy, the early identification of individuals at high risk and the precise characterization of underlying pathophysiological mechanisms remain unmet clinical needs. Conventional risk scores based on traditional factors account for only a fraction of the variability in outcomes. The discovery and validation of novel molecular and circulating biomarkers offer a promising opportunity to enhance early detection, refine risk stratification, and support personalized prevention and treatment strategies.
Well-established biomarkers routinely integrated into clinical practice, such as high-sensitivity cardiac troponins (hs-cTn), N-terminal pro-Brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) provide accurate measures of myocardial injury, hemodynamic stress and systemic inflammation, respectively. In parallel, emerging biomarkers -including growth differentiation factor 15 (GDF-15), soluble ST2, galectin-3, circulating microRNA signatures (e.g., miR-1, miR-133a, miR-208, miR-499), and metabolites such as trimethylamine-N-oxide (TMAO)- offer additional mechanistic insights into fibroinflammatory remodelling, endothelial dysfunction, metabolic dysregulation, and oxidative stress. These biomarkers highlight key molecular pathways, including NF-κB-driven inflammation, TGF-β-mediated fibrosis, mitochondrial dysfunction, dysregulated calcium handling, and programmed cell death.
This Special Issue aims to bring together basic, translational, and clinical research focused on emerging biomarkers of cardiovascular burden and myocardial injury, with particular focus on mechanistic insights, prognostic value, and clinical applicability.
Dr. Beatriz Martín-Carro
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiovascular disease
- myocardial injury
- heart failure
- biomarkers
- risk stratification
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
