Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 31
Special Issue Editors
Interests: endoplasmic reticulum stress; autophagy; cellular survival; systems biology
Special Issues, Collections and Topics in MDPI journals
Interests: endoplasmic reticulum stress; redox homeostasis of ER; ER membrane transporters
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The endoplasmic reticulum (ER) acts as an essential integrator of external and internal stimuli in order to preserve cellular homeostasis. This process is tightly regulated by a complex network of signalling pathways called the unfolded protein response (UPR). The accumulation of incorrectly folded proteins or metabolic imbalance in the ER lumen leads to ER stress, which primarily triggers the adaptive functions of the UPR to avoid cell damage. If readjustment efforts fail, then unresolved ER stress can lead to cell death mechanisms including apoptosis and other newly described cell-killing processes. It has also been posited that autophagy is initiated by ER stress as a protective pathway against cell damage. The role of ER stress is becoming increasingly important in a wide range of human diseases; it is crucial that we continue to investigate its effects as thoroughly as possible.
The aim of this Special Issue is to showcase current developments, challenges, and benefits in studying ER stress and related signalling pathways. This Special Issue will include both review articles and original research papers that address the diversity of pathways in cell death initiated by ER imbalance and their involvement in various diseases.
Dr. Orsolya Kapuy
Dr. Beáta Lizák
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ER stress
- apoptosis initiated by ER stress
- cellular survival
- redox homeostasis of ER
- autophagy initiated by ER stress
- cell death pathways initiated by ER stress
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
