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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 20 May 2026 | 4 articles | Viewed by 5537 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 20 May 2026 | 5 articles | Viewed by 5492 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

FTIR Miscrospectroscopy: Opportunities and Challenges

edited by Simona Sabbatini

submission deadline 20 May 2026 | 3 articles | Viewed by 5415 | Submission Open

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Microbiome Connections in Age-Related Diseases

edited by Shalini Jain

submission deadline 20 May 2026 | 2 articles | Viewed by 5405 | Submission Open

Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia

(This special issue belongs to the Section Molecular Microbiology)

Extraction, Identification and Quantification of Bioactive Molecules

edited by

Francesca Scionti

and Rosario Mare

submission deadline 20 May 2026 | 2 articles | Viewed by 5302 | Submission Open

Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 May 2026 | 3 articles | Viewed by 5138 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds

edited by

Kiril Gavazov

submission deadline 20 May 2026 | 5 articles | Viewed by 5097 | Submission Open

Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Host Responses to Virus Infection

edited by Hideki Hayashi and Yoshinao Kubo

submission deadline 20 May 2026 | 3 articles | Viewed by 5084 | Submission Open

Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm

(This special issue belongs to the Section Molecular Microbiology)

New Anti-cancer Agents: Design, Synthesis and Applications

edited by

Robert Czarnomysy

and

Anna Szymanowska

submission deadline 20 May 2026 | 2 articles | Viewed by 4978 | Submission Open

Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity

(This special issue belongs to the Section Molecular Pharmacology)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 May 2026 | 3 articles | Viewed by 4829 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

Diagnosis and Treatment of Osteoporosis

edited by

Fabio Vescini

submission deadline 20 May 2026 | 3 articles | Viewed by 4751 | Submission Open

Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Therapeutics for Respiratory Diseases

edited by

Roberto Plebani

submission deadline 20 May 2026 | 2 articles | Viewed by 4492 | Submission Open

Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 May 2026 | 2 articles | Viewed by 4386 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Diseases: From Physiology to Therapy

edited by

Vasileios Papaliagkas

submission deadline 20 May 2026 | 2 articles | Viewed by 4317 | Submission Open

Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets

edited by Jue Wang

submission deadline 20 May 2026 | 2 articles | Viewed by 4288 | Submission Open

Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular Oncology)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 May 2026 | 1 articles | Viewed by 4257 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition

edited by

Ioannis Alexandros Charitos

submission deadline 20 May 2026 | 1 articles | Viewed by 4141 | Submission Open

Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity

(This special issue belongs to the Section Molecular Biology)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 May 2026 | 2 articles | Viewed by 4065 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Ceramides and Ceramide Kinase

edited by Antonio Gomez-Muñoz

submission deadline 20 May 2026 | 3 articles | Viewed by 4023 | Submission Open

Keywords: cancer; cell survival; ceramides; ceramide 1-phosphate; inflammation

(This special issue belongs to the Section Biochemistry)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 20 May 2026 | 1 articles | Viewed by 3988 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Liposomes: Molecular Marvels in Drug Delivery

edited by

Parkson Lee-Gau Chong

and Juyang Huang

submission deadline 20 May 2026 | 1 articles | Viewed by 3928 | Submission Open

Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs

(This special issue belongs to the Section Molecular Biophysics)

The Role of Iodinated Compounds and Molecular Iodine in Human Disease

edited by

Carmen Aceves

submission deadline 20 May 2026 | 2 articles | Viewed by 3752 | Submission Open

Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement

(This special issue belongs to the Section Biochemistry)

Evolution and Genomics: Relevance to Current Issues

edited by

Roger Dawkins

and Sally Lloyd

submission deadline 20 May 2026 | 2 articles | Viewed by 3692 | Submission Open

Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease

edited by

Kurt A. Jellinger

submission deadline 20 May 2026 | 1 articles | Viewed by 3407 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 May 2026 | 2 articles | Viewed by 3345 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 May 2026 | 4 articles | Viewed by 3331 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions

edited by Gabriel Campolina-Silva and Héctor Contreras

submission deadline 20 May 2026 | 1 articles | Viewed by 3301 | Submission Open

Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cyclodextrins for Drug/iRNA Co-Delivery

edited by

Ivana Jarak

and

Ana Figueiras

submission deadline 20 May 2026 | 1 articles | Viewed by 3254 | Submission Open

Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins

(This special issue belongs to the Section Macromolecules)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 May 2026 | 2 articles | Viewed by 3240 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomedical Polymer Materials: Design, Synthesis or Applications

edited by Lourdes Franco

submission deadline 20 May 2026 | 1 articles | Viewed by 3211 | Submission Open

Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles

(This special issue belongs to the Section Materials Science)

RNA Editing/Modification in Health and Disease

edited by Valeriana Cesarini and

Piergiorgio La Rosa

submission deadline 20 May 2026 | 2 articles | Viewed by 3204 | Submission Open

Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 May 2026 | 1 articles | Viewed by 3191 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Flower Gene Regulation

edited by Wen‑Chieh Tsai

submission deadline 20 May 2026 | 2 articles | Viewed by 3070 | Submission Open

Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination

(This special issue belongs to the Section Molecular Plant Sciences)

The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition

edited by Taral R. Lunavat

submission deadline 20 May 2026 | 3 articles | Viewed by 2889 | Submission Open

Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Medical Applications of Polymer Materials

edited by Zhen Zhang

submission deadline 20 May 2026 | 2 articles | Viewed by 2853 | Submission Open

Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics

(This special issue belongs to the Section Macromolecules)

Lymphedema: From Mechanism to Treatment

edited by

Florent Morfoisse

submission deadline 20 May 2026 | 1 articles | Viewed by 2677 | Submission Open

Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention

edited by

Munish Puri

submission deadline 20 May 2026 | 2 articles | Viewed by 2658 | Submission Open

Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 20 May 2026 | 1 articles | Viewed by 2625 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application

edited by

Jelena Vekic

and

Aleksandra Zeljkovic

submission deadline 20 May 2026 | 2 articles | Viewed by 2576 | Submission Open

Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Food Compounds in the Prevention and Treatment of Non-Communicable Diseases

edited by

Aneta Kopeć

submission deadline 20 May 2026 | 1 articles | Viewed by 2536 | Submission Open

Keywords: bioactive compounds; dietary fiber; polyphenols; sulfur compounds; antioxidant; reduce oxidative stress; inflammation; non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in the Synthesis and Medical Application of Biomaterials

edited by

Csaba Balázsi

submission deadline 20 May 2026 | 1 articles | Viewed by 2444 | Submission Open

Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility

(This special issue belongs to the Section Materials Science)

Molecular Computational Research in Pharmacological Structure–Efficacy

edited by

José Rogério A. Silva

and Jerônimo Lameira

submission deadline 20 May 2026 | 2 articles | Viewed by 2420 | Submission Open

Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Cell Organelle Stress Responses and Implications in Human Diseases

edited by

Jaeseok Han

submission deadline 20 May 2026 | 2 articles | Viewed by 2281 | Submission Open

Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity

edited by

Rui Vitorino

submission deadline 20 May 2026 | 2 articles | Viewed by 2265 | Submission Open

Keywords: cardiovascular; ischemia; heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 20 May 2026 | 2 articles | Viewed by 2252 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry

edited by

Yang Gao

submission deadline 20 May 2026 | 1 articles | Viewed by 2231 | Submission Open

Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry

(This special issue belongs to the Section Materials Science)

Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design

edited by Aleksey E. Kuznetsov

submission deadline 20 May 2026 | 2 articles | Viewed by 2186 | Submission Open

Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design

(This special issue belongs to the Section Molecular Nanoscience)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 May 2026 | 2 articles | Viewed by 2167 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Emerging Biomaterials for Cartilage Regeneration

edited by

Valentina Vassallo

submission deadline 20 May 2026 | 1 articles | Viewed by 2029 | Submission Open

Keywords: osteoarthritis; glycosaminoglycans; biomaterials; cartilage regeneration; mesenchymal cells; chondrocytes

(This special issue belongs to the Section Biochemistry)

Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies

edited by

Siu Hong Dexter Wong

and Bohan Yin

submission deadline 20 May 2026 | 1 articles | Viewed by 2013 | Submission Open

Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release

(This special issue belongs to the Section Macromolecules)

Displaying special issue 2901-2950 on page 59 of 67.

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