Glioblastoma: Molecular Pathogenesis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 919
Special Issue Editors
Interests: molecular pathology; CNS tumors; hemopathology; uropathology
Special Issues, Collections and Topics in MDPI journals
Interests: uropathology; hematopathology; thyroid pathology; molecular pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
Glioblastoma (GBM) remains one of the most devastating and challenging neoplasms to treat, with a poor prognosis despite the availability of aggressive multimodal therapy. This Special Issue delves into the complexities of this aggressive brain tumor, exploring both its underlying molecular mechanisms and the forefront of therapeutic advancements.
Recent breakthroughs in understanding the genomic, transcriptomic, and epigenetic landscapes of GBM have revealed a remarkable degree of heterogeneity and adaptability, contributing to treatment resistance. Our aim is compile research that highlights critical aspects of GBM biology, including the roles of key signaling pathways, the tumor microenvironment, immune evasion, and the evolving landscape of driver mutations. Furthermore, this Special Issue aims to showcase innovative therapeutic strategies, from targeted therapies and immunotherapies to novel drug delivery systems and emerging approaches such as gene editing. We wish to provide a comprehensive overview of the current state of GBM research and offer insights into avenues for future therapeutic development to finally improve patient outcomes.
Dr. Maurizio Martini
Dr. Vincenzo Fiorentino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- glioblastoma
- molecular therapy
- pathogenesis
- immunotherapy
- brain tumor
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