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Advanced Research in Antioxidant Activity
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Advanced Research in Antioxidant Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 845

Special Issue Editors

Prof. Dr. Demetrios Kouretas

E-Mail Website
Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece
Interests: antioxidant; oleuropein; elenolic acid
Special Issues, Collections and Topics in MDPI journals
Dr. Fotios Tekos

E-Mail Website
Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece
Interests: antioxidants; redox; polyphenol; fasting; oxidative stress; glutathione; natural products; stress; toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress plays a crucial role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Antioxidants, whether derived from natural sources or synthetically developed, are essential for counteracting oxidative damage and maintaining cellular homeostasis.

In this Special Issue, we aim to explore cutting-edge research on the mechanisms of antioxidant activity, novel antioxidant compounds, and their applications in human health. We welcome original research and review articles which address molecular pathways, bioavailability, therapeutic potential, and advancements in the analytical techniques used to assess antioxidant efficacy.

Prof. Dr. Demetrios Kouretas
Dr. Fotios Tekos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • xenobiotics
  • oxidative stress
  • free radicals
  • reactive oxygen species
  • reactive nitrogen species
  • antioxidants
  • glutathione
  • toxicology
  • redox metabolism
  • redox imbalance

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Published Papers (1 paper)

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Research

20 pages, 3567 KiB  
Article
In Vivo Neuroprotective Effects of Alpinetin Against Experimental Ischemic Stroke Damage Through Antioxidant and Anti-Inflammatory Mechanisms
by Ratchaniporn Kongsui, Sitthisak Thongrong and Jinatta Jittiwat
Int. J. Mol. Sci. 2025, 26(11), 5093; https://doi.org/10.3390/ijms26115093 - 26 May 2025
Viewed by 646
Abstract
Ischemic stroke is the most common type of stroke and poses a major global health challenge due to its high mortality and lasting disability impact. The onset and progression of ischemic stroke are largely linked to oxidative stress and inflammatory responses. Alpinetin, a [...] Read more.
Ischemic stroke is the most common type of stroke and poses a major global health challenge due to its high mortality and lasting disability impact. The onset and progression of ischemic stroke are largely linked to oxidative stress and inflammatory responses. Alpinetin, a natural flavonoid found in the ginger family, exhibits various pharmacological properties, including antioxidant and anti-inflammatory activities. In this study, the neuroprotective potential of alpinetin in attenuating oxidative stress and inflammation against cerebral ischemic stroke was evaluated. Ninety male Wistar rats were randomly assigned to the sham operation group, the Rt.MCAO group, the Rt.MCAO+piracetam group, and the Rt.MCAO+alpinetin groups (25, 50, and 100 mg/kg BW). Cerebral infarction size, neuronal density, and antioxidant and anti-inflammatory activities were measured. Three days of treatment with alpinetin markedly reduced the infarct volume by 30% compared to the Rt.MCAO+vehicle-treated group. Additionally, rats treated with alpinetin exhibited a significant increase in neuronal density in the cortex, as well as in the CA1 and CA3 regions of the hippocampus. Furthermore, treatment with alpinetin ameliorated both the Rt.MCAO-induced increase in malondialdehyde (MDA) activity and the Rt.MCAO-induced decrease in catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in the cortex and hippocampus. Moreover, COX-2 and IL-6 protein levels were assessed using western blotting. The results showed that treatment with alpinetin (100 mg/kg BW) significantly reduced the expression levels of COX-2 and IL-6 in both the cortex and hippocampus. Our findings suggest that alpinetin significantly mitigates the effects of cerebral ischemia-induced brain damage through its antioxidant and anti-inflammatory properties and could potentially be developed as a therapeutic agent for stroke treatment. Full article
(This article belongs to the Special Issue Advanced Research in Antioxidant Activity)
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