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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition

edited by Xiaogang Li

submission deadline 31 Jan 2026 | 5 articles | Viewed by 4676 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Oxidative and Redox Signalling in Neurological Diseases

edited by

Malamati Kourti

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3644 | Submission Open

Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives

edited by

Luca Mastorino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2925 | Submission Open

Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype

(This special issue belongs to the Section Molecular Immunology)

25th Anniversary of IJMS: Updates and Advances in Molecular Biology

edited by

Irmgard Tegeder

Antonio Ieni

and

Costantino Balestra

submission deadline 31 Jan 2026 | 6 articles | Viewed by 2759 | Submission Open

Keywords: next-generation sequencing (NGS); CRISPR-Cas9; liquid biopsy; molecular diagnostics; personalized medicine; genome-wide association studies (GWAS)

(This special issue belongs to the Section Molecular Biology)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2659 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Pancreatic Diseases

edited by

Wasif Saif

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2353 | Submission Open

Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Voltage-Gating and Modulation in Ion Channels

edited by Joao Carvalho de Souza

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1541 | Submission Open

Keywords: voltage-gated ion channels; voltage sensing; voltage sensor coupling; new modulators; ion channel modulation; cell excitability

(This special issue belongs to the Section Molecular Biophysics)

Advances in Molecular Target and Anti-Cancer Therapies

edited by Laura Denisa Dragu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1536 | Submission Open

Keywords: cancer; conventional therapy; targeted therapy; immunotherapy; natural compounds; combinatorial therapy; molecular target; molecular mechanism; drug design; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion Channels as Therapeutic Target: Drug Design and Pharmacological Investigation (3rd Edition)

edited by

Gabriella Guerrini

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1467 | Submission Open

Keywords: LGIC; voltage-gated ion channel; other ion channels; biological studies; molecular modeling; drug design; synthesis

(This special issue belongs to the Section Molecular Pharmacology)

The Application of an Electron Microscope in the Study of Cell Structure

edited by

Ivana Bocina

submission deadline 31 Jan 2026 | 3 articles | Viewed by 1439 | Submission Open

Keywords: intracellular structure; organelles; cell surface structure; immuno-labeling

(This special issue belongs to the Section Molecular Biophysics)

Molecular Genetics and Genomics of Aquatic Crustaceans

edited by

Xianhong Meng

, Falin Zhou and Lingbo Ma

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1348 | Submission Open

Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms Related to Exercise

edited by Giorgia Scarfò

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1219 | Submission Open

Keywords: exercise; mitochondrial biogenesis; intracellular pathways; inflammation; oxidative stress; hypertrophy; metabolism angiogenesis

(This special issue belongs to the Section Molecular Biology)

Antitumor Activity of Natural Product

edited by

Fuad Fares

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1188 | Submission Open

Keywords: natural products; cancer treatment; cancer prevention; medicinal plants; medicinal mushrooms

(This special issue belongs to the Section Molecular Oncology)

Advances in Basic and Translational Research in Colorectal Cancer

edited by

Gina Gheorghe

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1174 | Submission Open

Keywords: colorectal cancer; diagnostic and prognostic biomarkers; genetic and epigenetic alterations; MMR/MSI; cytokine profiling; inflammatory mediators; gut microbiota; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Epilepsy: Exploring the Molecular Mechanisms and Potential Medications

edited by

Motohiro Okada

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1133 | Submission Open

Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Virus Infection, Resistance and Control

edited by

Carl Spetz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: plant virus; host– pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Synthesis, Biosynthesis and Implications of Chalcones

edited by

Pal Perjesi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 999 | Submission Open

Keywords: chalcones; biosynthesis; biochemistry

(This special issue belongs to the Section Biochemistry)

Molecular Research in Functional Nanomaterials

edited by

Łukasz Laskowski

submission deadline 31 Jan 2026 | 1 articles | Viewed by 935 | Submission Open

Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods

(This special issue belongs to the Section Molecular Nanoscience)

Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy

edited by Laura Necula

submission deadline 31 Jan 2026 | 1 articles | Viewed by 878 | Submission Open

Keywords: gastrointestinal cancers; biomarkers; early diagnosis; circulating molecules; non-invasive tests

(This special issue belongs to the Section Molecular Oncology)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 5th Edition

edited by

Grzegorz Wegrzyn

submission deadline 31 Jan 2026 | 1 articles | Viewed by 801 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Mechanisms of Receptor Activation

edited by

Zong Jie Cui

submission deadline 31 Jan 2026 | 1 articles | Viewed by 776 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease

edited by

Xinxin Song

submission deadline 31 Jan 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research

(This special issue belongs to the Section Molecular Informatics)

Molecular Design and Functional Applications of Polysaccharide Composites

edited by

Magdalena Krystyjan

Gohar Khachatryan

and

Karen Khachatryan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 729 | Submission Open

Keywords: polysaccharide composites; molecular design; functional applications

(This special issue belongs to the Section Materials Science)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Jan 2026 | Viewed by 615 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Oral Fibrosis and Oral Cancers: From Molecular Targets to Therapeutics

edited by Ila Pant

submission deadline 31 Jan 2026 | Viewed by 567 | Submission Open

Keywords: OSF; oral cancer; myofibroblast activation; collagen homeostasis; cancer stem cells; immunotherapy; monoclonal antibodies; DNA or RNA based targeted therapy; small molecule inhibitors; targeted nano-delivery systems; resistance to targeted therapies; molecular targets; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action

edited by Likun Gong,

Qiuping Qin

and Jing Chen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 551 | Submission Open

Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Medicinal Plants and Natural Products: Second Edition

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 31 Jan 2026 | 1 articles | Viewed by 524 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Recent Research in Composite Materials

edited by Aboulfazl Barati

submission deadline 31 Jan 2026 | Viewed by 472 | Submission Open

Keywords: composite materials; molecular-level structure– property relationships; polymer nanocomposites; interfacial interactions; sustainable and biodegradable composites; hybrid organic– inorganic systems

(This special issue belongs to the Section Materials Science)

Advances in Melanoma Immunotherapy and Molecular Mechanisms of Drug Resistance, Second Edition

edited by Antonino Guerrisi and

Italia Falcone

submission deadline 31 Jan 2026 | Viewed by 461 | Submission Open

Keywords: melanoma; targeted therapy; immunotherapy; precision medicine; biomarkers; omics technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Food Science: From Nutritional Value to Safety Evaluation

edited by

Mariachiara Bianco

submission deadline 31 Jan 2026 | 1 articles | Viewed by 449 | Submission Open

Keywords: nutraceutical; food safety; analytical methods; novel foods; food analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in the Pathophysiology and Therapy of Cerebral Gliomas

edited by

Placido Bruzzaniti

submission deadline 31 Jan 2026 | 1 articles | Viewed by 411 | Submission Open

Keywords: mutant IDH1 3; EVs; Ki67; HSV1-TK; glioma; lipid vesicles; viral vectors; ATRX; EGFR; IDH1; MGMT; 1p/19q codeletion

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiomyocytes Among Physiology and Pathophysiology: Molecular Insights and Therapeutic Implications

edited by Rosetta Ragusa and

Chiara Caselli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 384 | Submission Open

Keywords: sarcomere; metabolic stress; epigenetic mechanisms; exercise; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fine-Tuning Proteostasis: Insights into Ubiquitination and Deubiquitination Pathways

edited by

Kwang-Hyun Baek

submission deadline 31 Jan 2026 | Viewed by 367 | Submission Open

Keywords: deubiquitination; homeostasis; posttranslational modification; proteasomal degradation; protein quality control; proteolysis; proteostasis; signaling pathway; small molecule; ubiquitin-proteasome system; ubiquitination

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 31 Jan 2026 | Viewed by 286 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics; metabolomics; proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Brain Tumor Research and Treatment

edited by

Daniele Armocida

and

Davide Barbagallo

submission deadline 31 Jan 2026 | Viewed by 274 | Submission Open

Keywords: brain tumor; gliomas; brain metastases; translational research; molecular biology

(This special issue belongs to the Section Molecular Oncology)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 31 Jan 2026 | Viewed by 260 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biochemistry)

Recent Advances in Molecular Imaging and Therapy

edited by

Xuyi Yue

submission deadline 31 Jan 2026 | Viewed by 235 | Submission Open

Keywords: molecular imaging; therapy; clinical translation; precision medicine; radiotheranostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research of Estrogen Receptors in Health and Diseases

edited by

Maciej Iek Skrzypczak

submission deadline 31 Jan 2026 | Viewed by 233 | Submission Open

Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders

(This special issue belongs to the Section Biochemistry)

Emerging Therapeutic Potential of Organic Compound in Diseases

edited by

Katarzyna Kotwica-Mojzych

submission deadline 31 Jan 2026 | Viewed by 227 | Submission Open

Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Macrophage Metabolic Reprogramming in Inflammation

edited by

Ricardo Sánchez-Rodríguez

and

Roberta Angioni

submission deadline 31 Jan 2026 | Viewed by 221 | Submission Open

Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages

(This special issue belongs to the Section Molecular Immunology)

Pregnancy-Related Complications: Molecular Pathogenesis and Therapeutic Strategies

edited by

Alicia E. Damiano

submission deadline 31 Jan 2026 | Viewed by 217 | Submission Open

Keywords: pregnancy-related complications; placental dysfunction; maternal-fetal communication; extracellular vesicles; translational research; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Combinatorial Strategies in Anti-Obesity Therapeutics

edited by

James Ernest Blevins

and

Pawel K. Olszewski

submission deadline 31 Jan 2026 | Viewed by 204 | Submission Open

Keywords: obesity; high-fat diet; rodents; pharmacotherapy; body weight; food intake

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Long COVID Biology and Epidemiology: Predisposition, Molecular Mechanisms and Diagnostics

edited by Eduardo José Melo dos Santos

submission deadline 31 Jan 2026 | Viewed by 202 | Submission Open

Keywords: long COVID; genetic predisposing; long COVID epidemiology; pathogenesis; immunology of long COVID; long COVID etiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies

edited by Juliana Luporini Dreyfuss

submission deadline 31 Jan 2026 | Viewed by 198 | Submission Open

Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation

(This special issue belongs to the Section Molecular Biology)

New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids

edited by

Yuancong Xu

and Peng Cao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 197 | Submission Open

Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics

(This special issue belongs to the Section Molecular Nanoscience)

Natural Products and Compounds in Anticancer Drug Discovery

edited by

Diana I. Ivanova

submission deadline 31 Jan 2026 | Viewed by 191 | Submission Open

Keywords: antitumor plant compounds; antitumor plant-derived products; cellular pathways for natural drug apoptosis induction; chromatography of antitumor plant metabolites; modern technologies for recovery of plant anticancer substances; nanotechnology based natural anticancer drug products; plant-derived antitumor drug-protein interactions

(This special issue belongs to the Section Molecular Pharmacology)

Health-Promoting Benefits of Natural Products and Functional Foods, 2nd Edition

edited by

Emad Al-Dujaili

submission deadline 31 Jan 2026 | Viewed by 190 | Submission Open

Keywords: natural products; functional foods; health promotion; nutrigenomics; evidence-based preventive healthcare; phytochemicals; biomarkers; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Animal Nutrition and Muscle Biology

edited by Usuk Jung

submission deadline 31 Jan 2026 | Viewed by 188 | Submission Open

Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis

(This special issue belongs to the Section Molecular Biology)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by