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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Next Generation Sequencing in Human Diseases

edited by

Manuel Muro

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2830 | Submission Open

Keywords: NGS; single-cell analysis; metagenomics; forensic DNA analysis; precision medicine; genetic diagnostics; transplant monitoring; cell-free DNA; new allele and variant discovery

(This special issue belongs to the Section Molecular Informatics)

Oral Potentially Malignant Disorders and Oral Cancers: From Molecular Pathology to Therapeutic Approaches

edited by

Ana Caruntu

and Nicholas Kalavrezos

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2729 | Submission Open

Keywords: oral cancer; oral potentially malignant disorders; molecular mechanisms in oral cancer; detection of oral cancer; pathogenic mechanisms of oral cancer; immune system; translational oral cancer; microbiota oral cancer; therapy for oral cancer

(This special issue belongs to the Section Molecular Oncology)

The Role of Extracellular Histones in Patho(physio)logical Hemostasis

edited by Fabrizio Semeraro and

Mauro Coluccia

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2695 | Submission Open

Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms

edited by

Chengdu Qi

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2688 | Submission Open

Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Basis of Oral Immunology

edited by

Kenichi Kumagai

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2688 | Submission Open

Keywords: oral immunology; oral mucosa; immune tolerance; oral microbiome; oral diseases; periodontium; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2686 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Peptides: Discovery, Synthesis, and Therapeutic Applications

edited by

Chuan-Mu Chen

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2648 | Submission Open

Keywords: bioactive peptides; functional food-derived peptides; antimicrobial and antiviral peptides; peptide drug design and delivery; anticancer peptides; peptide-based therapeutics; regenerative medicine; immunomodulatory peptides; structure–function relationships; translational peptide research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health

edited by

Giusy Rita Caponio

and

Graziana Difonzo

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2613 | Submission Open

Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 20 Aug 2026 | 4 articles | Viewed by 2586 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation, 2nd Edition

edited by

Rosemary Kiernan

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2546 | Submission Open

Keywords: RNA biology; protein–RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Synthesis and Structural Studies of Potential Anticancer Drugs

edited by Janusz Madaj

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2514 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure–activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Artificial Intelligence Advancing Computer-Aided Drug Discovery

edited by

Raju Dash

submission deadline 20 Aug 2026 | 4 articles | Viewed by 2501 | Submission Open

Keywords: machine learning; deep learning; computer-aided drug design; target identification; AI-assisted molecular diagnosis; AI-driven pharmacokinetic profiling; virtual screening; network pharmacology; drug repurposing; molecular dynamics simulation; computational chemistry; AI in nanotechnology

(This special issue belongs to the Section Molecular Informatics)

Acute Myeloid Leukemia: From Molecular Insights to Therapeutic Innovations

edited by

Lukasz Szymanski

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2489 | Submission Open

Keywords: acute myeloid leukemia; AML; epigenetic Mechanisms; genetics; epigenetic regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Strategies in Bacterial Antibiotic Resistance

edited by Xuemei Yang

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2480 | Submission Open

Keywords: antibiotic resistance; resistance mechanisms; antibiotic resistance genes (ARGs); antibiotic tolerance; heteroresistance; horizontal gene transfer (HGT); compensatory evolution

(This special issue belongs to the Section Molecular Microbiology)

Epilepsy: Exploring the Molecular Mechanisms and Potential Medications

edited by

Motohiro Okada

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2459 | Submission Open

Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Diabetes and Its Complications

edited by

Giuseppe Murdolo

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2447 | Submission Open

Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Synaptic Structure and Function in the Healthy and Diseased Brain

edited by

Jacopo Meldolesi

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2411 | Submission Open

Keywords: molecular studies; axons; synapses; diseases; glial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition

edited by

Wojciech Makowski

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2405 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Biopolymer-Based Materials: Synthesis, Characterization and Applications for a Sustainable Future

edited by

Agnieszka Feliczak-Guzik

and

Agata Wawrzyńczak

submission deadline 20 Aug 2026 | 3 articles | Viewed by 2403 | Submission Open

Keywords: biodegradable polymers; biopolymers; biopolymer-based composite materials; synthesis and characterization of biopolymer materials; applications of biopolymers and biopolymer-based composites

(This special issue belongs to the Section Materials Science)

Macrophage Metabolic Reprogramming in Inflammation

edited by

Ricardo Sánchez-Rodríguez

and

Roberta Angioni

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2363 | Submission Open

Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Targets on Anticancer Research and Perspectives

edited by

Apostolos E. Papalois

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2327 | Submission Open

Keywords: anticancer; molecular targets; targeted cancer therapies; malignancy

(This special issue belongs to the Section Molecular Oncology)

The Cellular and Molecular Mechanisms of Central Nervous System Injury

edited by

Laurent R. Gauthier

and

José R. Pineda

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2327 | Submission Open

Keywords: central nervous system damage; CNS; oxidative stress; DNA damage responses; neuroregeneration; blood–brain barrier disruption

(This special issue belongs to the Section Molecular Neurobiology)

Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations

edited by

Paula Sandrin-Garcia

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2266 | Submission Open

Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy

(This special issue belongs to the Section Molecular Immunology)

From Synapse to Substance Use: Endocannabinoids and Cannabinoid Receptors in Brain Plasticity and Addiction Circuits

edited by Balapal S. Basavarajappa

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2261 | Submission Open

Keywords: anandamide; cannabis; alcohol; drug abuse; plasticity; neurotransmitters; cell-types; reward system

(This special issue belongs to the Section Molecular Neurobiology)

Coordination Chemistry: From Fundamental Principles to Multifunctional Applications

edited by

Kiril B. Gavazov

submission deadline 20 Aug 2026 | 4 articles | Viewed by 2206 | Submission Open

Keywords: coordination compounds; metal–ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal–organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Insights into Microbial Adaptations to Marine Plastics

edited by

Matan Oren

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2100 | Submission Open

Keywords: plastisphere; marine plastic debris; microbial colonization; biofilms; microbial adaptation; community assembly; quorum sesing; plastic biodegradation; biogeochemical cycling; antibiotic resistance genes; marine microbial ecology; metagenomics; microbe–plastic interactions; microbial succession

(This special issue belongs to the Section Molecular Microbiology)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2038 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Biomaterials and Antibacterial Materials for Medical Applications

edited by

Shixiong Yi

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2027 | Submission Open

Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings

(This special issue belongs to the Section Materials Science)

Advances in Stem Cell Biology and Translational Medicine

edited by Yangluowa Qu

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2014 | Submission Open

Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research

(This special issue belongs to the Section Molecular Biology)

Rewriting Medicine: Stem Cells and Regeneration

edited by

Tadahisa Sugiura

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1992 | Submission Open

Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering

(This special issue belongs to the Section Molecular Biology)

The Latest Molecular Insights into Animal Nutrition

edited by

Bin Feng

submission deadline 20 Aug 2026 | 3 articles | Viewed by 1991 | Submission Open

Keywords: reproduction; animal production; development; immunity; emissions; digestion efficiency; microbiome; metabolism; molecular signaling; nutritional strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1939 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Significance and Challenges of Plant-Derived Natural Compounds in Cancers

edited by Ba Vinh Le

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1932 | Submission Open

Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances and Views in Triple-Negative Breast Cancer

edited by

Ioannis Boutas

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1931 | Submission Open

Keywords: breast cancer; molecular biology; personalized medicine; triple-negative breast cancer

(This special issue belongs to the Section Molecular Oncology)

Advances in Fluorescent Sensors

edited by

Levente Cseri

and

Ervin Kovács

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1925 | Submission Open

Keywords: fluorescence probe; fluorescent nanomaterials; analyte recognition; fluorescence imaging; real-time monitoring; photoinduced electron transfer; Förster resonance energy transfer; genetically encoded indicators; sensor devices; fluorescence microscopy

(This special issue belongs to the Section Materials Science)

Kidney Disease: Molecular Insights and Emerging Therapies

edited by

Yaochun Zhang

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1918 | Submission Open

Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension

edited by

Swati Dabral

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1907 | Submission Open

Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation

(This special issue belongs to the Section Molecular Biology)

Novel Insights into Mitochondrial Signaling and Homeostasis in Metabolic Diseases

edited by Ching-Yi Chen

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1904 | Submission Open

Keywords: diabetes mellitus; cardiovascular disease; fatty liver; chronic kidney disease; mitochondrial homeostasis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Effects of Radiation in Health and Disease

edited by

Raffaella Lazzarini

submission deadline 20 Aug 2026 | 3 articles | Viewed by 1874 | Submission Open

Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Microglia in Neurological Diseases

edited by

Pyung-Hwan Kim

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1851 | Submission Open

Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)

(This special issue belongs to the Section Molecular Neurobiology)

Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes

edited by

Feng Liu

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1797 | Submission Open

Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Compounds in Neurological Diseases

edited by

Ivan Cruz-Chamorro

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1731 | Submission Open

Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols, flavonoids, melatonin, etc.); nutraceuticals (bioactive peptides, hydrolysates, etc.); neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Telocytes: Unraveling Their Roles in Health and Disease

edited by

Sanda Cretoiu

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1716 | Submission Open

Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Thromboinflammation

edited by Ana B. Arroyo

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1693 | Submission Open

Keywords: thromboinflammation; coagulation; inflammation; immune system; sepsis; stroke; autoimmune diseases; cancer; hematology; biomarkers; translational medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular Research in Functional Nanomaterials

edited by

Łukasz Laskowski

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1670 | Submission Open

Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods

(This special issue belongs to the Section Molecular Nanoscience)

Research on the Key Role of Ubiquitination in Signaling and Cancer

edited by

Bo Zhao

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1650 | Submission Open

Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development

(This special issue belongs to the Section Molecular Oncology)

Molecular Research and Insights into Anti-Cancer Vaccines

edited by

Alfredo Martínez

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1648 | Submission Open

Keywords: anti-cancer vaccines; tumor antigens; molecular mechanisms; immunotherapy; molecular oncology

(This special issue belongs to the Section Molecular Oncology)

New Progress in Peptidic Protease Inhibitors

edited by

Roberta Ettari

and Carla Di Chio

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1647 | Submission Open

Keywords: peptide inhibitors; infectious diseases; cancer; metabolic disorders; neurological disorders; inflammation

(This special issue belongs to the Section Biochemistry)

Research Progress of Fluorescent Proteins in Molecular Biology

edited by Matteo Grenzi

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1638 | Submission Open

Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques

(This special issue belongs to the Section Molecular Biology)

New Insight into Bacteriophage and Their Potential Applications

edited by Wilfried Moreira

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1555 | Submission Open

Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

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