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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 31 May 2026 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Signaling and Stress Adaptation in Plants: 2nd Edition

edited by

Kangdi Hu

submission deadline 31 May 2026 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 20 Jun 2026 | 10 articles | Viewed by 15799 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments

edited by

Luisa Agnello

and Anna Maria Ciaccio

submission deadline 20 Jun 2026 | 3 articles | Viewed by 8802 | Submission Open

Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Myocardial Disease: Molecular Pathology and Treatments

edited by

Kazufumi Nakamura

submission deadline 20 Jun 2026 | 3 articles | Viewed by 8343 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; amyloidosis; myocarditis; sarcoidosis; genetic abnormalities; immune mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Acute Myeloid Leukemia

edited by

Walter Fiedler

submission deadline 20 Jun 2026 | 4 articles | Viewed by 8242 | Submission Open

Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Skin Diseases: 3rd Edition

edited by

Naoko Kanda

submission deadline 20 Jun 2026 | 3 articles | Viewed by 7704 | Submission Open

Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cardiac Disease

edited by

Daniela Rossin

submission deadline 20 Jun 2026 | 2 articles | Viewed by 6091 | Submission Open

Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

edited by

Oriana Trubiani

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Jun 2026 | 2 articles | Viewed by 5984 | Submission Open

Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Soybean

edited by Zhengjun Xia

submission deadline 20 Jun 2026 | 6 articles | Viewed by 5490 | Submission Open

Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction

(This special issue belongs to the Section Molecular Plant Sciences)

Tissue Engineering Related Biomaterials: Progress and Challenges

edited by

Mihaela Violeta Ghica

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4556 | Submission Open

Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors

(This special issue belongs to the Section Materials Science)

Radiation-Induced DNA Damage and Toxicity

edited by

Mohammad Asif Sherwani

and

Muhammad Maqbool

submission deadline 20 Jun 2026 | 3 articles | Viewed by 4451 | Submission Open

Keywords: radiation; DNA damage; toxicity; immune response

(This special issue belongs to the Section Molecular Biology)

Plant Pathogen Interactions: 3rd Edition

edited by

Sixue Chen

submission deadline 20 Jun 2026 | 1 articles | Viewed by 3753 | Submission Open

Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Glycoconjugates: From Structure to Therapeutic Application

edited by Rosana Ribić

submission deadline 20 Jun 2026 | 4 articles | Viewed by 3736 | Submission Open

Keywords: glycoconjugates (glycoproteins and glycopeptides; glycolipids; proteoglycans); glyconanoparticles; carbohydrate-based therapeutics; glycomics; glycosylation; glycoengineering; glycobiology; synthesis of glycoconjugates; vaccine development; drug delivery; biomarkers; diagnostics; immunotherapy; regenerative medicine; therapeutic applications

(This special issue belongs to the Section Molecular Pharmacology)

Crop Biotic and Abiotic Stress Tolerance: 4th Edition

edited by

Fazhan Qiu

submission deadline 20 Jun 2026 | 4 articles | Viewed by 3404 | Submission Open

Keywords: biotic and abiotic stress tolerance; QTL/gene mapping and clones; gene editing; marker-assisted selection; genomic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition

edited by

Federica Mannino

submission deadline 20 Jun 2026 | 2 articles | Viewed by 3318 | Submission Open

Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media

edited by

Ana M. Mainar

and

José S. Urieta

submission deadline 20 Jun 2026 | 1 articles | Viewed by 3081 | Submission Open

Keywords: water solubility ; water-solute interactions ; solvation; hydrophobic and hydrophilic effects ; improving water solubility and prediction ; solution of chemicals in biological media ; diffusivity ; drug transport and bioavailability; chemicals diffusivity across biological barriers

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Bioactive Compounds and Their Antioxidant Role: 2nd Edition

edited by Tamara Jurina

submission deadline 20 Jun 2026 | 3 articles | Viewed by 2862 | Submission Open

Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Aspects of Reproductive Medicine

edited by Wei Chen

submission deadline 20 Jun 2026 | 1 articles | Viewed by 2646 | Submission Open

Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 20 Jun 2026 | 1 articles | Viewed by 2084 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

Role of Immune Cells in Cancers

edited by Helga Maria Schmetzer

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1957 | Submission Open

Keywords: cancer; immune monitoring; immune escape; immune activation

(This special issue belongs to the Section Molecular Oncology)

Advances in Brassica Crop Metabolism and Genetics (Second Edition)

edited by

Bo Sun

and

Honghao Lv

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1761 | Submission Open

Keywords: brassica crop; genomics; transcriptomics; proteomics; metabolomics; gene editing; metabolite synthesis and regulation; phylogeny and taxonomy; physiological traits; biotic/abiotic stresses; biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Obesity and Cancer Risk: Molecular Mechanisms and Perspectives

edited by

Hendrik Lehnert

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1558 | Submission Open

Keywords: epidemiology of obesity and cancer; experimental models of cancer in obesity; genetic and epigenetics of obesity and metabolic dysfunction associated cancer; tumor microenvironment; basis of metastatic spread of cancer in obesity; therapeutic modeling and targeting

(This special issue belongs to the Section Molecular Oncology)

New Molecular Mechanisms of Genotoxicity

edited by Francesca Marcon and

Roberta Meschini

submission deadline 20 Jun 2026 | Viewed by 1522 | Submission Open

Keywords: DNA damage; DNA repair; genotoxicity; carcinogenesis; chronic degenerative diseases; human health; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Cardiac Repair and Regeneration: From Pathogenesis to Therapeutic Perspectives

edited by Marina Leone and Olaf Bergmann

submission deadline 20 Jun 2026 | Viewed by 1489 | Submission Open

Keywords: heart regeneration; cardiomyocyte proliferation; cell cycle; ischemic heart disease; myocardial infarction; stem cells; cardiac repair; polyploidization; tissue engineering; immune cells; metabolism; cell death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds from Foods Against Diseases

edited by Jongbin Lim

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1429 | Submission Open

Keywords: diet-related diseases; bioactive compounds; analytical techniques; functional foods; molecular interaction; health benefits

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1352 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies

edited by

Lishi Yang

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development

(This special issue belongs to the Section Molecular Biology)

Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses

edited by

Vidmantas Bendokas

submission deadline 20 Jun 2026 | 2 articles | Viewed by 934 | Submission Open

Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response

(This special issue belongs to the Section Molecular Plant Sciences)

Research on System Biology Methods and Tools for Integrating Omics Data

edited by Yuanyan Xiong

submission deadline 20 Jun 2026 | 2 articles | Viewed by 911 | Submission Open

Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Leukemia: Molecular Immune Mechanisms

edited by

Mohammad Hojjat-Farsangi

submission deadline 20 Jun 2026 | Viewed by 558 | Submission Open

Keywords: leukemia; immune system; Genetic Mutations and Alterations; Immune Evasion Mechanisms; Immune Cell Dysfunction; Cytokine Networks; Bone Marrow Microenvironment; immunotherapy strategies

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 20 Jun 2026 | 1 articles | Viewed by 556 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations; “ Omics” ; spatial biology of 3D

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Actinomycetes-Derived Natural Products

edited by Fong Tian Wong

submission deadline 20 Jun 2026 | Viewed by 532 | Submission Open

Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition

edited by Marzena Helena Olesińska and Magdalena Szmyrka

submission deadline 20 Jun 2026 | Viewed by 389 | Submission Open

Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases

(This special issue belongs to the Section Molecular Immunology)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 20 Jun 2026 | Viewed by 307 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Telomeres in Development, Senescence and Genome Instability: 2nd Edition

edited by Michal Zalzman

submission deadline 20 Jun 2026 | Viewed by 299 | Submission Open

Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management

edited by Alessio Bruni

submission deadline 20 Jun 2026 | Viewed by 298 | Submission Open

Keywords: urothelial cancer; bladder cancer; radiation therapy; trimodality approach; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering

edited by

Elisa Boanini

submission deadline 20 Jun 2026 | Viewed by 217 | Submission Open

Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility

(This special issue belongs to the Section Materials Science)

Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment

edited by Madan Mohan Kwatra

submission deadline 20 Jun 2026 | Viewed by 214 | Submission Open

Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sustainable Material Development Through Waste Utilization: From Molecular Insights to Functional Applications

edited by

Rosie Yagmur Yegin

submission deadline 20 Jun 2026 | Viewed by 202 | Submission Open

Keywords: sustainable materials; waste-derived materials; biodegradable polymers; green chemistry; functionalization; structure– property relationships; chemical modification; recycling; valorization; circular economy; composites; analytical techniques; industrial waste; agricultural waste

(This special issue belongs to the Section Materials Science)

Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside

edited by Antonio Arnaiz-Villena

submission deadline 20 Jun 2026 | Viewed by 197 | Submission Open

Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV

(This special issue belongs to the Section Molecular Immunology)

Graphene-based Nanocomposites

edited by

Oleksandr Ivasenko

submission deadline 20 Jun 2026 | Viewed by 194 | Submission Open

Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Horizons in Pain Therapeutics

edited by Alaa Abd-Elsayed

submission deadline 20 Jun 2026 | Viewed by 193 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomics and Epigenetics of Stem Cell: An Update

edited by

Vikas Malik

submission deadline 20 Jun 2026 | Viewed by 191 | Submission Open

Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors

(This special issue belongs to the Section Molecular Genetics and Genomics)

Infectious Diseases and Infection Models in Laboratory Animals

edited by

Hiraku Sasaki

and Fumio Ike

submission deadline 20 Jun 2026 | Viewed by 174 | Submission Open

Keywords: infection model; Infectious diseases in laboratory animals; bacterial infection; viral infection; parasitic infection; molecular diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Bioactive Compounds for Human Health, 3rd Edition

edited by

Hongjie Zhang

submission deadline 20 Jun 2026 | Viewed by 172 | Submission Open

Keywords: natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement

(This special issue belongs to the Section Molecular Pharmacology)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by