Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 467
Special Issue Editors
Interests: advanced separation methods; supercritical fluids; process development; thermodynamic properties; biocides; cosmetic; thermodynamics; solvation; fluid mixtures
Special Issues, Collections and Topics in MDPI journals
Interests: thermophysical properties; thermodynamic modeling; calorimetry; pressurized fluids; ionic liquids; solubilities; electrochemistry; electrolytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Knowledge of the solubility and mass transport of drugs or other chemicals in aqueous media and in biological tissues is fundamental for the understanding of many phenomena in the fields of chemistry and biology, and also for the development of many industrial processes for the production of drugs and fine or bulk chemicals.
As is known, because its physical and chemical attributes, its readily availability in nature and its non-poisonous character, water is the solvent par excellence. Also, being the most abundant component in many living organisms, water plays a key role as a solvent that helps transport substances such as oxygen, nutrients or drugs in tissues. In fact, the pharmaceutical industry is a productive sector highly dependent on water. This is essential for production of active ingredients ,either as a solvent for extraction, as a vehicle for reagents, or as an excipient, among other uses.
In relation to the bioavailability of therapeutic agents, along with the route of administration, the solubility in the aqueous medium and the diffusion of the bioactive can play very important roles. Something similar could be said regarding the action of contaminants or other chemical agents. In the case of drugs orally delivered to humans, it has been estimated that when having aqueous solubilities less than 100 mg/mL, their absorption through the intestinal tract may be very limited.
Both solubility and diffusivity in aqueous media and organic tissues are determined by microscopic factors, that is, molecular structures and interactions between the molecules of the system. Thus, this molecular approach to solubility and diffusivity constitutes the main focus of the present Special Issue of the IJMS.
This Issue therefore invites submissions of manuscripts corresponding to original research and review articles addressing molecular aspects of the solubility in aqueous media and diffusivity of drugs and other chemicals in tissues and biological organisms.
The scope of this Issue mainly encompasses the following:
- Theoretical foundations of solubility and solubilization in water. Molecular interpretation and prediction
- Application of novel theories and technologies to calculations and experimental studies on solubility and diffusibility in water, in the fields of engineering, chemistry, medicine, biology, food, materials, etc.
- Transport of chemical substances through biological barriers,
- Analysis of the molecular diffusivity of bioactive compounds in biological media.
Dr. Ana M. Mainar
Prof. Dr. José S. Urieta
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- water solubility
- water-solute interactions
- solvation, hydrophobic and hydrophilic effects
- improving water solubility and prediction
- solution of chemicals in biological media
- diffusivity
- drug transport and bioavailability
- chemicals diffusivity across biological barriers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
