Genomics and Epigenetics of Stem Cell: An Update
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 66
Special Issue Editor
Interests: stem cells; cell biology; molecular biology; genomics; proteomics; biochemistry; RNA-seq; ChIP-seq; ATAC-seq
Special Issue Information
Dear Colleagues,
Stem cells maintain a delicate balance between self-renewal and differentiation, guided by transcription factor networks and dynamic epigenetic regulation. Chromatin remodeling, DNA methylation, histone modifications, and microRNAs collectively regulate stem cell fate, ensuring reversible gene expression patterns essential for development and tissue homeostasis. Disruptions in these mechanisms can drive dysregulation, aging, senescence, or malignancy.
This Special Issue examines how genomic and epigenetic mechanisms govern stem cell self-renewal, fate determination, and differentiation, including intrinsic/extrinsic signaling pathways that sustain stemness. A deeper understanding of these features promises to define novel therapeutic strategies for regenerative medicine and disease intervention. We invite original research and reviews addressing genomic and epigenetic regulation in stem cells, with emphasis on chromatin dynamics, epigenetic crosstalk, and molecular pathways shaping cellular identity. Submissions exploring epigenetic interventions, particularly those that deepen our understanding of how altered epigenetic mechanisms enable the development of bioengineered stem cell-based regenerative therapies for diseases, are especially encouraged.
Dr. Vikas Malik
Guest Editor
Manuscript Submission Information
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Keywords
- stem cells
- epigenetics
- genomics
- cell fate
- self-renewal
- differentiation
- regenerative medicine
- transcription factors
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