Molecular Horizons in Pain Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 43
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic pain continues to pose a major global health burden, affecting millions and challenging conventional therapeutic approaches. As research has progressed, it has become increasingly evident that effective pain management must go beyond symptom control and target the molecular and cellular underpinnings of chronic pain syndromes. This Special Issue seeks to present a comprehensive exploration of emerging interventional techniques through the lens of molecular and cellular science, highlighting how advanced therapies intersect with the biology of pain.
We invite original research or review contributions that showcase cutting-edge interventions—such as spinal cord stimulation (SCS), peripheral nerve stimulation (PNS), and regenerative therapies including stem cell treatments and platelet-rich plasma (PRP) injections—while emphasizing their molecular mechanisms of action. Articles will explore how these interventions modulate key signaling pathways, neuroimmune interactions, and gene expression profiles involved in pain chronification. Topics may include the role of inflammatory cytokines, ion channel dysregulation, glial cell activation, and neuroplastic changes that contribute to central and peripheral sensitization.
Furthermore, this issue aims to highlight how advances in molecular diagnostics, such as transcriptomic and proteomic profiling, are paving the way for more personalized and targeted approaches in interventional pain management. Understanding how these interventions influence cellular behavior—such as the recruitment of endogenous stem cells, alteration of nociceptive signal transduction, or attenuation of pro-inflammatory microenvironments—offers promising directions for optimizing therapeutic efficacy.
Dr. Alaa Abd-Elsayed
Guest Editor
Manuscript Submission Information
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Keywords
- spinal cord stimulation
- peripheral nerve stimulation
- stem cell therapy
- platelet-rich plasma (PRP) injections
- chronic pain management
- interventional pain procedure
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