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Molecular Aspects of Reproductive Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 452

Special Issue Editor


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Guest Editor
The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha 410013, China
Interests: spermatogenesis; oogenesis; microenvironment; organ interactions

Special Issue Information

Dear Colleagues,

This Special Issue “Molecular Aspects of Reproductive Medicine” aims to explore the molecular mechanisms underpinning gametogenesis and reproductive health, with a focus on advancing our understanding of cellular and systemic regulation. We invite contributions that address (1) regulatory mechanisms and metabolic pathways governing developmental trajectories and critical checkpoints in spermatogenesis/oogenesis; (2) intercellular signaling networks and microenvironmental crosstalk within the testicular/ovarian niches, emphasizing molecular mediators of cell–cell interactions; and (3) systemic influences of extra-gonadal tissues (e.g., brain, gut) on reproductive processes, including hormonal, metabolic, and immune pathways. By integrating cutting-edge molecular approaches—such as omics, single-cell analyses, and functional genomics—this collection seeks to unravel the complexity of reproductive biology. Submissions may include original research, reviews, or methodological advances that elucidate molecular targets for diagnostics, therapeutic interventions, or biomarker discovery in reproductive disorders.

Dr. Wei Chen
Guest Editor

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Keywords

  • spermatogenesis
  • oogenesis
  • microenvironment
  • organ interactions
  • molecular regulation
  • gametogenesis
  • signaling pathways
  • reproductive disorders

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Published Papers (1 paper)

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Review

24 pages, 1609 KiB  
Review
Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities
by Difan Cai, Junda Li, Zekang Peng, Rong Fu, Chuyang Chen, Feihong Liu, Yiwang Li, Yanjing Su, Chunyun Li and Wei Chen
Int. J. Mol. Sci. 2025, 26(8), 3496; https://doi.org/10.3390/ijms26083496 - 8 Apr 2025
Viewed by 405
Abstract
Male infertility is intricately linked to dysregulated cell death pathways, including ferroptosis, cuproptosis, pyroptosis, and autophagy. Ferroptosis, driven by iron-dependent lipid peroxidation through the Fenton reaction and inactivation of the GPX4/Nrf2/SLC7A11 axis, disrupts spermatogenesis under conditions of oxidative stress, environmental toxin exposure, or [...] Read more.
Male infertility is intricately linked to dysregulated cell death pathways, including ferroptosis, cuproptosis, pyroptosis, and autophagy. Ferroptosis, driven by iron-dependent lipid peroxidation through the Fenton reaction and inactivation of the GPX4/Nrf2/SLC7A11 axis, disrupts spermatogenesis under conditions of oxidative stress, environmental toxin exposure, or metabolic disorders. Similarly, cuproptosis—characterized by mitochondrial dysfunction and disulfide stress due to copper overload—exacerbates germ cell apoptosis via FDX1 activation and NADPH depletion. Pyroptosis, mediated by the NLRP3 inflammasome and gasdermin D, amplifies testicular inflammation and germ cell loss via IL-1β/IL-18 release, particularly in response to environmental insults. Autophagy maintains testicular homeostasis by clearing damaged organelles and proteins; however, its dysregulation impairs sperm maturation and compromises blood–testis barrier integrity. These pathways intersect through shared regulators; reactive oxygen species and mTOR modulate the autophagy–pyroptosis balance, while Nrf2 and FDX1 bridge ferroptosis–cuproptosis crosstalk. Therapeutic interventions targeting these mechanisms have shown promise in preclinical models. However, challenges persist, including the tissue-specific roles of gasdermin isoforms, off-target effects of pharmacological inhibitors, and transgenerational epigenetic impacts of environmental toxins. This review synthesizes current molecular insights into the cell death pathways implicated in male infertility, emphasizing their interplay and translational potential for restoring spermatogenic function. Full article
(This article belongs to the Special Issue Molecular Aspects of Reproductive Medicine)
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