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Glycoconjugates: From Structure to Therapeutic Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 175

Special Issue Editor


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Guest Editor
Department of Nursing, University Center Varaždin, University North, Jurja Križanića 31b, HR-42000 Varazdin, Croatia
Interests: organic synthesis; medicinal chemistry; glycoconjugates; glicopeptides; ligand-receptor interactions
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Special Issue Information

Dear Colleagues,

Glycoconjugates play important an role in biological recognition, signaling, and disease mechanisms. They are complex biomolecules that are formed by the covalent binding of carbohydrates to proteins and lipids. Advances in the structural characterization, glycoengineering, and biomedical applications of glycoconjugates have enhanced our understanding of their functional significance, paving the way for innovative therapeutic strategies. This Special Issue aims to highlight innovative research on the structure, synthesis, and function of glycoconjugates, as well as their translational potential in drug development, vaccine design, diagnostics, and regenerative medicine.

We invite researchers from diverse disciplines to present their latest findings in the field of glycoproteins, glycolipids, proteoglycans, synthetic glycoconjugates, and their roles in health and disease. By compiling research from leading experts and emerging scholars, this Special Issue will provide a comprehensive overview of the latest advancements in glycoconjugate research and their therapeutic applications.

This Special Issue is supervised by Dr. Rosana Ribić and assisted by our Topical Advisory Panel Member Dr. Rajendra Rohokale,  (Guo Research Group, University of Florida, Gainesville, FL, USA).

Dr. Rosana Ribić
Guest Editor

Manuscript Submission Information

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Keywords

  • glycoconjugates (glycoproteins and glycopeptides, glycolipids,proteoglycans)
  • glyconanoparticles
  • carbohydrate-based therapeutics
  • glycomics
  • glycosylation
  • glycoengineering
  • glycobiology
  • synthesis of glycoconjugates
  • vaccine development
  • drug delivery
  • biomarkers
  • diagnostics
  • immunotherapy
  • regenerative medicine
  • therapeutic applications

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Published Papers (1 paper)

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Research

19 pages, 1218 KiB  
Article
Targeting Recipient Dendritic Cells with Sialic Acid-Modified Donor Alloantigen Prolongs Skin Transplant Survival
by Monica Sen, Qi Peng, Kulachelvy Ratnasothy, Martino Ambrosini, Hakan Kalay, Jordan Bazoer, Kate E. Adams, Nouhad El Ouazzani, Abdessamad Ababou, David B. Guiliano, Jose I. Saldaña, Yvette van Kooyk, Giovanna Lombardi and Lesley A. Smyth
Int. J. Mol. Sci. 2025, 26(13), 6168; https://doi.org/10.3390/ijms26136168 - 26 Jun 2025
Abstract
Mature dendritic cells (DCs) are known to activate effector immune responses, whereas steady state immature DCs can induce tolerance. Several studies have targeted immature murine quiescent DCs in vivo with antigen, including donor alloantigens, for the induction of tolerance. Receptors expressed by specific [...] Read more.
Mature dendritic cells (DCs) are known to activate effector immune responses, whereas steady state immature DCs can induce tolerance. Several studies have targeted immature murine quiescent DCs in vivo with antigen, including donor alloantigens, for the induction of tolerance. Receptors expressed by specific DC subsets have been also targeted with antibodies linked with antigens to induce tolerance; for instance, in vivo targeting of the DCIR2+ DC subset with donor alloantigen resulted in long-term survival of heart and skin transplants. DCs also express sialic acid immunoglobulin-like lectin (Siglec) receptors, and these have been successfully targeted with myelin oligiodendrocyte glycoprotein (MOG) antigen to induce tolerance in experimental autoimmune encephalomyelitis (EAE). We investigated, in a mismatched model of skin transplant (B6Kd into B6 recipient mice), whether targeting a sialylated alloantigen Kd (Sia-Kd) to Siglecs on recipient DCs promoted transplant survival. The injection of α2,3 Sia-Kd into B6 recipient mice prior to B6Kd skin transplantation, by binding to Batf3 dependent DCs, resulted in prolonged skin graft survival and an increase in CD4+CD62L+Foxp3+ Tregs. Targeting Siglecs on DC subsets in vivo represents a novel way of improving transplant survival. Full article
(This article belongs to the Special Issue Glycoconjugates: From Structure to Therapeutic Application)
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