Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 508
Special Issue Editor
Special Issue Information
Dear Colleagues,
Glioblastoma remains the most aggressive and lethal primary brain tumor in adults, with limited therapeutic options and poor survival rates. Recent advances in molecular profiling technologies have transformed our understanding of glioblastoma biology, leading to refined diagnostic criteria, identification of distinct molecular subtypes, and emergence of personalized treatment strategies.
This Special Issue of the International Journal of Molecular Sciences brings together a collection of submissions that highlight recent developments in the molecular characterization of glioblastoma, with a focus on its diagnostic, prognostic, and therapeutic implications. The topics covered include the integration of DNA methylation-based classifiers into diagnostic workflows, the role of comprehensive genomic profiling in detecting actionable mutations and gene fusions, and the utility of transcriptomic and proteomic signatures in subclassifying tumors. The collection also addresses challenges in clinical implementation, including tumor heterogeneity, evolving classification systems, and the need for CLIA-certified platforms. Collectively, these articles underscore the critical role of precision oncology in glioblastoma management and point toward a future where individualized therapy guided by molecular diagnostics may significantly improve patient outcomes.
Dr. Madan Mohan Kwatra
Guest Editor
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Keywords
- glioblastoma
- diagnosis
- molecular characterization
- personalized treatment
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