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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 May 2026 | 1 articles | Viewed by 1680 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Applications of Phytochemicals in Drug Synthesis

edited by

Gregorio Peron

submission deadline 20 May 2026 | 1 articles | Viewed by 1678 | Submission Open

Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Toxicants and Their Effects on Innate Immune Function and Inflammatory Response

edited by

James M. Harper

submission deadline 20 May 2026 | 1 articles | Viewed by 1650 | Submission Open

Keywords: ecotoxicology; innate immunity; inflammation; pesticides; plasticizers; pattern-recognition receptors

(This special issue belongs to the Section Molecular Toxicology)

New Insights into Kidney Diseases—2nd Edition

edited by

Kan Katayama

submission deadline 20 May 2026 | 1 articles | Viewed by 1599 | Submission Open

Keywords: kidney disease; focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Progression of Movement Disorders

edited by

Michał Latalski

and

Pilar Gomez-Garre

submission deadline 20 May 2026 | 1 articles | Viewed by 1592 | Submission Open

Keywords: movement disorders; molecular mechanisms; neurodegenerative diseases; therapeutic targets; biomarkers; neuroinflammation; protein misfolding; mitochondrial dysfunction; environmental factors; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Eukaryotic DNA Replication—from Bench to Bedside

edited by Heinz-Peter Nasheuer

submission deadline 20 May 2026 | 1 articles | Viewed by 1562 | Submission Open

Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins— selection; licensing and firing; replication forks— smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 20 May 2026 | 1 articles | Viewed by 1554 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Structural Characterization and Pharmacological Activity of Natural Compounds

edited by

Ana Amić

submission deadline 20 May 2026 | 1 articles | Viewed by 1545 | Submission Open

Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans

edited by

Enrique Viguera

submission deadline 20 May 2026 | 1 articles | Viewed by 1518 | Submission Open

Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 20 May 2026 | 2 articles | Viewed by 1498 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Translational Preclinical Research

edited by

Mariano Gabri

submission deadline 20 May 2026 | 2 articles | Viewed by 1493 | Submission Open

Keywords: translational preclinical research; drug discovery; cancer therapies; in vitro and in vivo experiments; biological mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria as a Therapeutic Target for Anti-Cancer Drugs

edited by

Dalia Marija Kopustinskiene

submission deadline 20 May 2026 | Viewed by 1491 | Submission Open

Keywords: mitochondria; cancer; apoptosis; oxidative phosphorylation; Warburg effect; cardiolipin; inflammation

(This special issue belongs to the Section Molecular Oncology)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 20 May 2026 | 2 articles | Viewed by 1436 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 20 May 2026 | 2 articles | Viewed by 1428 | Submission Open

Keywords: rare diseases; genotype– phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Synthesis Manufacturing and Biomedical Applications of Nanofibers Scaffold

edited by

Marco Antonio Álvarez Pérez

and

Vincenzo Guarino

submission deadline 20 May 2026 | 1 articles | Viewed by 1391 | Submission Open

Keywords: scaffold manufacturing; nanofibers; 3D platforms; biohybrid scaffolds; biomolecules; functionalization; biomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Molecular Research on Pregnancy Complication Mechanisms

edited by

Aleksandra Stefanović

submission deadline 20 May 2026 | 1 articles | Viewed by 1373 | Submission Open

Keywords: hypertensive pregnancy disorders; gestational diabetes; intrauterine growth restriction; maternal metabolism in pregnancy complications; genetic and epigenetic mechanisms in pregnancy complications; immunology in pregnancy complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by

Natalia Nowacka-Jechalke

and

Marta Kinga Lemieszek

submission deadline 20 May 2026 | 2 articles | Viewed by 1358 | Submission Open

Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure– activity relationship; anticancer potential; immunomodulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pancreatic Diseases: Molecular Pathology and Therapeutics

edited by

Maria Ines Vaccaro

submission deadline 20 May 2026 | 1 articles | Viewed by 1340 | Submission Open

Keywords: pancreatic cancer; acute pancreatitis; chronic pancreatitis; diabetes; inflammation; molecular markers; therapeutic strategies; genetic predispositions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 20 May 2026 | 2 articles | Viewed by 1331 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 20 May 2026 | 2 articles | Viewed by 1321 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: From Molecular Mechanisms to Therapeutics

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 May 2026 | 1 articles | Viewed by 1229 | Submission Open

Keywords: melanoma; molecular mechanism; signaling pathways; genetic mutations; cancer therapy/treatment; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Multifunctional Magnetic Nanoparticles: Synthesis, Properties, and Biomedical Applications

edited by

Krishtappa Manjunatha

submission deadline 20 May 2026 | Viewed by 1216 | Submission Open

Keywords: magnetic nanoparticles; molecular functionalization; magnetocaloric materials; drug delivery systems; molecular imaging; magnetic memory; nanocomposites; nanophosphors; environmental remediation; energy storage materials; magnetic biosensing; biofunctional interfaces

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Electrochemical Nanomaterials for Energy and Catalysis

edited by

Sankar Sekar

submission deadline 20 May 2026 | 1 articles | Viewed by 1193 | Submission Open

Keywords: advanced micro- and nanomaterials for electrochemical applications; electrochemical energy storage; electrocatalysis; photoelectrochemical water splitting; electrochemical sensors; supercapacitor; batteries; nanocomposites and functionalized materials; energy storage and conversion application; natural resources-based materials

(This special issue belongs to the Section Molecular Nanoscience)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 May 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Analysis on Effector and Regulatory Molecules in Renal Diseases

edited by

Takashi Oda

submission deadline 20 May 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: effector molecules; regulatory molecules; membrane attack complex (MAC); perforin; granzyme; immune complex; neutrophil extracellular traps (NETs); proteolytic enzymes; reactive oxygen species; infection-related glomerulonephritis (IRGN); nephritis-associated plasmin receptor (NAPlr); streptococcal pyrogenic exotoxin B (SPEB); adhesion molecules

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Surfactants: Design, Synthesis and Application

edited by

Urszula Bazylinska

submission deadline 20 May 2026 | 1 articles | Viewed by 994 | Submission Open

Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic– lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics

(This special issue belongs to the Section Materials Science)

New Molecular Insights into Antibacterial Material

edited by Rahela Carpa

submission deadline 20 May 2026 | 1 articles | Viewed by 979 | Submission Open

Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials

(This special issue belongs to the Section Materials Science)

The Role of Extracellular Vesicles in Disease and Therapeutic Applications

edited by Sunyoung Park

submission deadline 20 May 2026 | 1 articles | Viewed by 970 | Submission Open

Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Aquatic Organisms Models Dedicated to Disease

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 May 2026 | Viewed by 921 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Roles of the Gut-Brain Axis (GBA) in Health and Disease

edited by Vinata Vedam-Mai

submission deadline 20 May 2026 | 1 articles | Viewed by 909 | Submission Open

Keywords: gut– brain axis; gut microbiota; brain function; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Study of Plant Bioactive Compounds

edited by

Anna Weronika Sobańska

submission deadline 20 May 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Intrinsically Disordered Proteins (IDPs): From Structure to Mechanism and Function

edited by

Kyouhoon Han

submission deadline 20 May 2026 | Viewed by 896 | Submission Open

Keywords: IDP; NMR; completely unstructured; pre-structured; PreSMo; target binding

(This special issue belongs to the Section Biochemistry)

Synthesis and Application of Natural and Inspired-Natural Products

edited by Mauro de Nisco

submission deadline 20 May 2026 | 1 articles | Viewed by 891 | Submission Open

Keywords: natural products; natural substances; derivative; synthesis; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research in Membrane Transporters, Channels, and Receptors

edited by Ivana Vrhovac Madunic

submission deadline 20 May 2026 | 1 articles | Viewed by 872 | Submission Open

Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Viral Pathogenesis: From Infection to Host Response

edited by

Quang Duy Trinh

submission deadline 20 May 2026 | 1 articles | Viewed by 838 | Submission Open

Keywords: viruses; viral pathogenesis; virus– host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation

(This special issue belongs to the Section Molecular Microbiology)

Unraveling the Molecular Landscape of Primary Brain Tumors

edited by

Giuseppe Lombardi

, Francesco Pasqualetti and Tamara Ius

submission deadline 20 May 2026 | Viewed by 761 | Submission Open

Keywords: primary brain tumors; molecular oncology; glioma; glioblastoma; biomarkers; targeted therapy; epigenetics; tumor microenvironment; genomic profiling; translational research

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Transcription Factors in Antioxidant Pathways

edited by

Eleonora Stanca

submission deadline 20 May 2026 | 1 articles | Viewed by 745 | Submission Open

Keywords: transcription factor; oxidative stress; NRF1/2; NRF3; NFkB; P53; antioxidant-response elements; neurologial diseases; metabolic diseases; cancer

(This special issue belongs to the Section Molecular Biology)

Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 May 2026 | Viewed by 725 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Primary Colorectal Cancer and Liver Metastases

edited by Alexandros E. Giakoustidis

submission deadline 20 May 2026 | 1 articles | Viewed by 718 | Submission Open

Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chessboard: How Plants and Insects Outsmart Each Other

edited by

Mateusz Labudda

submission deadline 20 May 2026 | 1 articles | Viewed by 674 | Submission Open

Keywords: acarology; biotic stress; entomology nitric oxide; oxidative stress; phytopathology; reactive nitrogen species; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Ocular Inflammation and Infection

edited by

Christine Fardeau

submission deadline 20 May 2026 | 1 articles | Viewed by 657 | Submission Open

Keywords: ocular infections; uveitis; choroiditis; masquerade syndrome; pseudo-uveitis; intraocular lymphoma; retinal dystrophy; ocular inflammation; neuroinflammation; immunotherapy-induced uveitis; autoimmune eye diseases; sarcoidosis; OCT; indocyanine green angiography

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 20 May 2026 | 1 articles | Viewed by 653 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene– environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Approaches in Biomedicine: Innovations and Insights

edited by

Carlos Leon

submission deadline 20 May 2026 | Viewed by 628 | Submission Open

Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Repair Mechanisms of Stem Cells

edited by

Ana Flores

and

Jose Joaquin Merino

submission deadline 20 May 2026 | Viewed by 622 | Submission Open

Keywords: stem cell biology; stem cells; stem cell therapy; tissue regeneration

(This special issue belongs to the Section Biochemistry)

Lipoproteins—Opportunities for the Development of Nanotherapeutics in Chronic Disease

edited by

Thomas Grewal

submission deadline 20 May 2026 | Viewed by 619 | Submission Open

Keywords: lipoproteins; LDL; HDL; nanotherapeutics; chronic disease; targeted therapy; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Skeletal Muscle Adaptation

edited by

Michele Salanova

submission deadline 20 May 2026 | 1 articles | Viewed by 614 | Submission Open

Keywords: skeletal muscle; adaptive responses; muscle physiology; genomics; transcriptomics; proteomics; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Biological Breeding and Molecular Biology of Tropical Crops

edited by Yongzan Wei

submission deadline 20 May 2026 | 1 articles | Viewed by 598 | Submission Open

Keywords: tropical crops; biological breeding; tropical fruit; molecular biology; gene editing; transcrip-tional regulation; genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine

edited by

Mariapaola Marino

submission deadline 20 May 2026 | 1 articles | Viewed by 550 | Submission Open

Keywords: innate immunity; adaptive immunity; inflammation; autoantibodies; peptides; cytokines; receptors; leukocytes; extracellular vesicles; signal transduction; apoptosis

(This special issue belongs to the Section Molecular Immunology)

New Biomarkers in Pancreatic Diseases

edited by