Toxicants and Their Effects on Innate Immune Function and Inflammatory Response
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 483
Special Issue Editor
Interests: aging; endocrinology; comparative physiology; animal models; cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Toxicants such as pesticides and plasticizing agents have become ubiquitous in both terrestrial and aquatic environments. Although the effects of these man-made substances on reproductive and metabolic functions have been studied thoroughly, how they may impact other aspects of physiological functions are not as well known. For example, innate immune function serves as a critical line of defense against pathogens in both invertebrates and vertebrates, and there is mounting evidence that exposure to various toxicants may significantly impair innate immune function in multiple species. In addition, within vertebrates, the inflammatory response is an important component of an innate immune response, and it is also an important mediator of the effects of tissue injury. As with innate immune function, in general, there are data suggesting that the inflammatory response is significantly altered by exposure to various toxicants. The purpose of this Special Issue is to highlight the impact of environmental pollutants on innate immune function and the inflammatory response in both invertebrate and vertebrate animal models.
Dr. James M. Harper
Guest Editor
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Keywords
- ecotoxicology
- innate immunity
- inflammation
- pesticides
- plasticizers
- pattern-recognition receptors
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