Analysis on Effector and Regulatory Molecules in Renal Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 163
Special Issue Editor
Interests: rapidly progressive glomerulonephritis; ANCA-associated vasculitis; infection-related glomerulonephritis; post-infectious acute glomerulonephritis; renal interstitial fibrosis; renal transplantation–recurrence of glomerulonephritis; renal transplantation-infection-related complications; role of complements in renal disease; chronic kidney disease; kidney diseases caused by viral infection; kidney diseases caused by bacterial infection
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Special Issue Information
Dear Colleagues,
With the remarkable progress of molecular-targeted drugs, such as monoclonal antibody drugs, the elucidation of the molecular mechanisms of various diseases is now directly linked to the development of therapeutic drugs for these diseases. The same is true for kidney diseases, and we have now entered an era in which various molecular-targeted drugs are being applied in clinical practice. In this Special Issue titled “Analysis on Effector and Regulatory Molecules in Renal Diseases”, we call for manuscripts that focus on the effector molecules that contribute to tissue damage and regulatory molecules that protect against them in various kidney diseases.
Well-known final attack effector molecules include complement-related membrane attack complex (MAC) and NK/NKT cell-related perforin and granzyme, but when considering them as therapeutic targets, knowledge of the activation, production and regulatory mechanisms of these molecules is necessary. In addition to these final effector molecules, pathogenic molecules that work at intermediate stages of tissue injury would also be important. Immune complexes are molecules frequently seen in various kidney diseases; they are thought to be produced in circulation or in renal tissues in situ, and to cause tissue damage via complement activation, etc., but the mechanism is not fully understood in detail. In ANCA-associated renal vasculitis and other diseases, neutrophil-derived effector molecules, such as neutrophil extracellular traps (NETs), and proteolytic enzymes (neutrophil elastase, myeloperoxidase) accompanied by reactive oxygen species have attracted considerable attention in tissue damage research. Meanwhile, in infection-related glomerulonephritis, nephritis-associated plasmin receptor (NAPlr) and streptococcal pyrogenic exotoxin B (SPEB) have been reported as the pathogenic molecules that induce nephritis. On the other hand, adhesion molecules are involved in the accumulation of effector cells in local kidney tissues and, therefore, have the potential to be good therapeutic targets.
This Special Issue aims to deepen the understanding of effector and regulatory molecules in renal diseases, which relates to the search for the best therapeutic targets. In this Special Issue of “Analysis on Effector and Regulatory Molecules in Renal Diseases”, we welcome case reports, original research and review articles addressing, but not limited to, the roles of effector as well as regulatory molecules on kidney injury.
Prof. Dr. Takashi Oda
Guest Editor
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Keywords
- effector molecules
- regulatory molecules
- membrane attack complex (MAC)
- perforin
- granzyme
- immune complex
- neutrophil extracellular traps (NETs)
- proteolytic enzymes
- reactive oxygen species
- infection-related glomerulonephritis (IRGN)
- nephritis-associated plasmin receptor (NAPlr)
- streptococcal pyrogenic exotoxin B (SPEB)
- adhesion molecules
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