Unraveling the Molecular Landscape of Primary Brain Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 6
Special Issue Editor
Interests: brain tumors; targeted therapy; quality of life; brain metastases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Primary brain tumors represent a heterogeneous group of neoplasms with distinct biological behaviors, clinical presentations, and prognostic outcomes. Despite recent advances in neuro-oncology, the prognosis for many of these malignancies—particularly high-grade gliomas—remains poor. Molecular research has dramatically reshaped our understanding of the pathogenesis, classification, and progression of brain tumors, leading to significant changes in diagnostic criteria and the development of targeted therapeutic strategies.
This Special Issue aims to highlight current progress and future directions in the molecular characterization of primary brain tumors. We invite contributions that explore the genetic, epigenetic, transcriptomic, and proteomic alterations driving tumor development and therapeutic resistance. Studies investigating novel biomarkers for diagnosis, prognosis, or treatment response, as well as research into the tumor microenvironment, cell signaling pathways, and mechanisms of immune evasion, are particularly welcome.
By gathering original research and comprehensive reviews, this Special Issue seeks to promote interdisciplinary dialog and accelerate the translation of molecular findings into clinical applications. All submissions should be aligned with the journal’s focus on advancing cancer research and patient care through high-quality, impactful scientific contributions.
Suggested topics include, but are not limited to, the following:
- Molecular classification and subclassification of primary brain tumors;
- Genomic and epigenomic profiling;
- Novel diagnostic, prognostic, and predictive biomarkers;
- Molecular mechanisms of treatment resistance;
- Tumor microenvironment and immune landscape;
- Targeted therapies and personalized medicine approaches;
- Integration of multi-omics data for tumor characterization;
- Preclinical models for molecular studies in brain tumors.
We look forward to you submissions.
Dr. Giuseppe Lombardi
Guest Editor
Manuscript Submission Information
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Keywords
- primary brain tumors
- molecular oncology
- glioma
- glioblastoma
- biomarkers
- targeted therapy
- epigenetics
- tumor microenvironment
- genomic profiling
- translational research
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