Eukaryotic DNA Replication—from Bench to Bedside
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 August 2025) | Viewed by 392
Special Issue Editor
Interests: cell cycle control; DNA replication; genome stability; posttranslational modifications; replication fork proteins; initiation reaction; Okazaki fragment synthesis; protein‒protein and protein‒DNA interactions; enzyme mechanisms; DNA polymerases; DNA primase; ssDNA-binding proteins
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Special Issue Information
Dear Colleagues,
Genome instability is a hallmark of cancer and central in the development of cancerous cells from normal cells. DNA replication is one of the most important cellular processes to avoid genome instability. In recent years, tremendous advances in the understanding of the molecular mechanisms of DNA replication have been achieved in eukaryotes from yeast to humans, allowing deeper insights into the way cells divide. The understanding of DNA replication at the molecular level using biochemical and structural biological methods as well as at the cellular and organismal level using high-resolution microscopy and high-throughput technologies has provided us with answers to many central questions regarding DNA replication, including how eukaryotic genomes are accurately replicated and how genome duplication is controlled by origin activation and firing in space and time. These findings and future DNA replication studies will yield novel insights into the development of human diseases, including cancer, which will allow the development of new ideas and tools for the treatment of these diseases.
This Special Issue, “Eukaryotic DNA Replication—From Bench to Bedside”, aims to collect high-quality research articles, review articles, and communications in the field of human DNA replication from all areas of biomedical research, including cell, molecular, and structural biology. These articles will advance our understanding of this essential cellular process. They will display the current state of the art and pave the way to future, novel medical therapies to prevent cancer and other genetic diseases.
Prof. Dr. Heinz-Peter Nasheuer
Guest Editor
Manuscript Submission Information
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Keywords
- genome stability
- cell cycle
- DNA replication
- chromatin replication
- replication origins—selection, licensing and firing
- replication forks—smoothly progressing and under stress
- role of DNA replication in cancer and other human diseases
- disease treatment opportunities
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