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New Insights into Kidney Diseases—2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 348

Special Issue Editor


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Guest Editor
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan
Interests: focal segmental glomerulosclerosis; genetic kidney disease; kidney diseases; nephrotic syndrome; podocyte
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue on “New Insights into Kidney Diseases”.

Chronic kidney disease is categorized by the degree of albuminuria/proteinuria and an estimated glomerular filtration rate in urinalysis and blood tests, respectively, and is a lifestyle-related disease that affects one in eight people. It is caused by various causes, such as diabetic nephropathy, chronic glomerulonephritis, and nephrosclerosis. New drug discoveries other than the existing nephroprotective drugs, such as renin-angiotensin-aldosterone system inhibitors and sodium-glucose cotransporter-2 inhibitors, are still under development. Various studies have revealed that podocytes, terminally differentiated cells that exist outside the glomerular basement membrane, are greatly involved in the progression of chronic kidney disease.

The aim of this Special Issue is to gather original research articles and review articles that focus on new insights in kidney diseases. Articles focused on genetic forms of kidney disease are especially encouraged.

Dr. Kan Katayama
Guest Editor

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Keywords

  • kidney disease
  • focal segmental glomerulosclerosis
  • genetic kidney disease
  • minimal change disease
  • nephrotic syndrome
  • podocyte

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Published Papers (1 paper)

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Research

11 pages, 1041 KiB  
Article
Quantification of Urine and Plasma Levels of Extracellular Vesicles in a Cohort of Kidney Transplant Recipients and Chronic Kidney Disease Patients
by Valentine Jacob, Quentin de Berny, François Brazier, Claire Presne, Julien Lion, Hakim Ouled-Haddou, Valérie Metzinger-Le Meuth, Gabriel Choukroun, Laurent Metzinger and Nicolas Guillaume
Int. J. Mol. Sci. 2025, 26(8), 3635; https://doi.org/10.3390/ijms26083635 - 11 Apr 2025
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Abstract
Extracellular vesicles (EVs) have a key role in intercellular communication. We hypothesized that EVs are biomarkers of nephropathy or kidney allograft rejection. We screened patients with chronic kidney disease (CKD) and kidney transplant (KT) recipients. We measured the urine and plasma levels of [...] Read more.
Extracellular vesicles (EVs) have a key role in intercellular communication. We hypothesized that EVs are biomarkers of nephropathy or kidney allograft rejection. We screened patients with chronic kidney disease (CKD) and kidney transplant (KT) recipients. We measured the urine and plasma levels of total EVs overall and EV subpopulations (positive for podocalyxin, aquaporin-1, CD133, CD144, CD19, CD3, CD16, CD56, or CD41). We included 92 patients with CKD, 70 KT recipients, and 33 healthy volunteers. In CKD, the total urine EV concentration was correlated positively with the estimated glomerular filtration rate (eGFR), but none of the subpopulations was identified as a potential biomarker of nephropathy. Among the KT recipients, 30 had good allograft function and 40 had allograft disease (13 with antibody-mediated rejections (ABMR), 12 with T-cell-mediated rejection (TCMR), and 15 with allograft dysfunction). Patients with ABMR had low plasma levels of EVs derived from B-cells, T-cells, and endothelium (p = 0.003, 0.009, and 0.005, respectively). Patients with TCMR had a low urine level of EVs derived from endothelium (p = 0.05). EVs derived from B-cells, T-cells, and endothelium might be biomarkers of kidney allograft rejection. However, we did not identify biomarkers of nephropathy in CKD. Full article
(This article belongs to the Special Issue New Insights into Kidney Diseases—2nd Edition)
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