Melanoma: From Molecular Mechanisms to Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 493
Special Issue Editor
Interests: apoptosis; autophagy; cancer therapy/treatment; drug resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Melanoma is one of the most malignant, heterogeneous, and therapy-resistant types of cancer, resulting from the neoplastic transformation of pigment cells—melanocytes.
Treatment for this cancer causes many problems because melanoma is a heterogeneous disease that is resistant to standard chemotherapy.
As a result of neoplastic transformation, cell signaling pathways, including MAPK/ERK, PI3K/AKT/mTOR, NF-kB, and Wnt/β-catenin, are dysregulated. Changes occur at the cellular level: proliferation increases, cells acquire invasive features and the ability to migrate, and the process of cellular apoptosis is inhibited.
The development of targeted therapy directed directly against oncogenes or focused on inhibiting signaling pathways activated as a result of neoplastic transformation seems promising. The search for an effective therapeutic strategy for melanoma focuses on identifying new potential sites for targeted therapy.
While targeted therapies and immunotherapies have revolutionized melanoma treatment, a significant challenge remains in the development of resistance to these therapies. Research on an effective model of treatment for this cancer is still ongoing.
This Special Issue aims to present the latest original research and reviews on molecular mechanisms and clinical strategies for the treatment of melanoma.
I hope that the latest research results presented in this Special Issue will contribute to a deeper understanding of the processes involved in melanoma progression and facilitate the development of novel clinical strategies for this tumor.
Dr. Dorota Ciołczyk-Wierzbicka
Guest Editor
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Keywords
- melanoma
- molecular mechanism
- signaling pathways
- genetic mutations
- cancer therapy/treatment
- drug resistance
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