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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Development and Abiotic Stress Response Regulation via Alternative Splicing

edited by

Yong-Hwan Moon

submission deadline 20 May 2026 | 4 articles | Viewed by 7654 | Submission Open

Keywords: plants; development; abiotic stress responses; alternative splicing; transcriptional regulation; signaling; splicing factors

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition

edited by

Elia Ranzato

submission deadline 20 May 2026 | 4 articles | Viewed by 7533 | Submission Open

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition

edited by

Klaus H. Hoffmann

submission deadline 20 May 2026 | 4 articles | Viewed by 7526 | Submission Open

Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology

(This special issue belongs to the Section Molecular Immunology)

Bioprinting: Progress and Challenges

edited by

Rui Vitorino

submission deadline 20 May 2026 | 1 articles | Viewed by 7460 | Submission Open

Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research

(This special issue belongs to the Section Materials Science)

Advances in G Protein-Coupled Receptor Signaling

edited by

Dariusz Szukiewicz

submission deadline 20 May 2026 | 1 articles | Viewed by 7294 | Submission Open

Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗

(This special issue belongs to the Section Molecular Immunology)

Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics

edited by

Elisabetta Ferrara

submission deadline 20 May 2026 | 2 articles | Viewed by 7055 | Submission Open

Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 20 May 2026 | 7 articles | Viewed by 6878 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 20 May 2026 | 2 articles | Viewed by 6766 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Opioid Research

edited by Matthew E. Layton

submission deadline 20 May 2026 | 5 articles | Viewed by 6687 | Submission Open

Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes

(This special issue belongs to the Section Molecular Pharmacology)

Perspectives of Molecular Genetics and Genomics in Human Mendelian Diseases

edited by

Marta Rusmini

submission deadline 20 May 2026 | 3 articles | Viewed by 6685 | Submission Open

Keywords: functional genomics; omics; genetic disease; human; molecular mechanisms; genome editing; biomarkers; computational genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microbiome Connections in Age-Related Diseases

edited by Shalini Jain

submission deadline 20 May 2026 | 2 articles | Viewed by 6224 | Submission Open

Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia

(This special issue belongs to the Section Molecular Microbiology)

Technical Developments and Recent Applications of Cellular Molecular Imaging

edited by Hanae Sato

submission deadline 20 May 2026 | 3 articles | Viewed by 6206 | Submission Open

Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging

(This special issue belongs to the Section Molecular Biology)

Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 20 May 2026 | 4 articles | Viewed by 6136 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics

edited by

Ivano Condò

submission deadline 20 May 2026 | 2 articles | Viewed by 6081 | Submission Open

Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 May 2026 | 3 articles | Viewed by 5889 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 May 2026 | 3 articles | Viewed by 5854 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Pathogenesis and Treatment of Pregnancy Complications

edited by

Melissa Wilson

submission deadline 20 May 2026 | 3 articles | Viewed by 5821 | Submission Open

Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Nature to Medicine: Exploring Natural Products for New Therapies

edited by

Alejandro Madrid

submission deadline 20 May 2026 | 3 articles | Viewed by 5808 | Submission Open

Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate

(This special issue belongs to the Section Molecular Pharmacology)

Extraction, Identification and Quantification of Bioactive Molecules

edited by

Francesca Scionti

and Rosario Mare

submission deadline 20 May 2026 | 2 articles | Viewed by 5807 | Submission Open

Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

FTIR Miscrospectroscopy: Opportunities and Challenges

edited by Simona Sabbatini

submission deadline 20 May 2026 | 3 articles | Viewed by 5648 | Submission Open

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles

edited by

Vitaliy Borisov

and

Elena Forte

submission deadline 20 May 2026 | 2 articles | Viewed by 5604 | Submission Open

Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target

(This special issue belongs to the Section Molecular Biophysics)

Diagnosis and Treatment of Osteoporosis

edited by

Fabio Vescini

submission deadline 20 May 2026 | 3 articles | Viewed by 5566 | Submission Open

Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Anti-cancer Agents: Design, Synthesis and Applications

edited by

Robert Czarnomysy

and

Anna Szymanowska

submission deadline 20 May 2026 | 2 articles | Viewed by 5546 | Submission Open

Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity

(This special issue belongs to the Section Molecular Pharmacology)

The Effects of Dietary Supplements, Functional Foods and Nutraceuticals in the Immune System

edited by

Kaleta Beata

submission deadline 20 May 2026 | 1 articles | Viewed by 5535 | Submission Open

Keywords: dietary supplements; functional foods; immune system; immunomodulation; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

edited by

Julita Kulbacka

submission deadline 20 May 2026 | 3 articles | Viewed by 5397 | Submission Open

Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI

(This special issue belongs to the Section Molecular Oncology)

Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds

edited by

Kiril Gavazov

submission deadline 20 May 2026 | 5 articles | Viewed by 5395 | Submission Open

Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Host Responses to Virus Infection

edited by Hideki Hayashi and Yoshinao Kubo

submission deadline 20 May 2026 | 3 articles | Viewed by 5387 | Submission Open

Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm

(This special issue belongs to the Section Molecular Microbiology)

Neurological Diseases: From Physiology to Therapy

edited by

Vasileios Papaliagkas

submission deadline 20 May 2026 | 2 articles | Viewed by 5281 | Submission Open

Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 20 May 2026 | 3 articles | Viewed by 4860 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Therapeutics for Respiratory Diseases

edited by

Roberto Plebani

submission deadline 20 May 2026 | 2 articles | Viewed by 4810 | Submission Open

Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 May 2026 | 1 articles | Viewed by 4707 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 May 2026 | 2 articles | Viewed by 4644 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Arthritis: Focus on Pathologies, Symptoms and Therapy

edited by

Katarína Bauerová

submission deadline 20 May 2026 | 1 articles | Viewed by 4538 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 May 2026 | 2 articles | Viewed by 4470 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Ceramides and Ceramide Kinase

edited by Antonio Gomez-Muñoz

submission deadline 20 May 2026 | 3 articles | Viewed by 4456 | Submission Open

Keywords: cancer; cell survival; ceramides; ceramide 1-phosphate; inflammation

(This special issue belongs to the Section Biochemistry)

Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets

edited by Jue Wang

submission deadline 20 May 2026 | 2 articles | Viewed by 4422 | Submission Open

Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular Oncology)

Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition

edited by

Ioannis Alexandros Charitos

submission deadline 20 May 2026 | 1 articles | Viewed by 4386 | Submission Open

Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease

edited by

Kurt A. Jellinger

submission deadline 20 May 2026 | 2 articles | Viewed by 4355 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 May 2026 | 4 articles | Viewed by 4269 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Calcium Homeostasis of Cells in Health and Disease: Third Edition

edited by

Péter Szentesi

and

László Csernoch

submission deadline 20 May 2026 | 6 articles | Viewed by 4181 | Submission Open

Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease

(This special issue belongs to the Section Biochemistry)

Liposomes: Molecular Marvels in Drug Delivery

edited by

Parkson Lee-Gau Chong

and Juyang Huang

submission deadline 20 May 2026 | 1 articles | Viewed by 4145 | Submission Open

Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs

(This special issue belongs to the Section Molecular Biophysics)

The Role of Iodinated Compounds and Molecular Iodine in Human Disease

edited by

Carmen Aceves

submission deadline 20 May 2026 | 2 articles | Viewed by 4091 | Submission Open

Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement

(This special issue belongs to the Section Biochemistry)

New Insights into Chemotherapeutic Agents in Cancer Treatment

edited by

Eleni Stamoula

submission deadline 20 May 2026 | 1 articles | Viewed by 4079 | Submission Open

Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics

(This special issue belongs to the Section Molecular Pharmacology)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 May 2026 | 2 articles | Viewed by 4052 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Evolution and Genomics: Relevance to Current Issues

edited by

Roger Dawkins

and Sally Lloyd

submission deadline 20 May 2026 | 2 articles | Viewed by 3819 | Submission Open

Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Biomaterials for Tissue Regeneration: Current Progress and Future Directions

edited by

Ana Caruntu

and Horia Barbu

submission deadline 20 May 2026 | 2 articles | Viewed by 3699 | Submission Open

Keywords: biomaterials; biocompatibility; tissue engineering; tissue defect; rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells; antimicrobial

(This special issue belongs to the Section Materials Science)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 May 2026 | 4 articles | Viewed by 3653 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 May 2026 | 2 articles | Viewed by 3619 | Submission Open

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 May 2026 | 2 articles | Viewed by 3617 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Characterization of Plant–Microbe Interactions

edited by

Cristina Pinedo-Rivilla

submission deadline 20 May 2026 | 3 articles | Viewed by 3603 | Submission Open

Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 2651-2700 on page 54 of 67.

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