Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 53
Special Issue Editor
Interests: periodontology; health economy; orale hygiene; medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Periodontal diseases represent one of the most prevalent inflammatory conditions worldwide, affecting nearly half of the adult population and serving as a significant source of oral health burden. Beyond their local manifestations, these diseases have been increasingly recognized as contributors to systemic inflammation with implications for numerous conditions, including cardiovascular disease, diabetes, adverse pregnancy outcomes, neurodegenerative disorders, and respiratory infections. The paradigm shift in our understanding of periodontal diseases—from a simple bacterial infection to a complex dysbiotic condition influenced by host immune responses, genetic factors, and environmental modifiers—has opened new avenues for research and clinical applications. Modern periodontal medicine embraces a multidisciplinary approach that integrates molecular biology, immunology, microbiology, genetics, and computational sciences.
This Special Issue aims to compile cutting-edge research on various aspects of periodontal diseases, from fundamental molecular mechanisms to advanced diagnostic approaches and innovative therapeutic strategies. We welcome original research articles, comprehensive reviews, and perspective pieces that address, but are not limited to, the following topics:
- Molecular and cellular mechanisms underlying periodontal tissue destruction and regeneration;
- Microbiome dynamics in periodontal health and disease;
- Novel biomarkers and diagnostic technologies for early detection and risk assessment;
- Genetic, epigenetic, and environmental determinants of periodontal diseases;
- Bidirectional relationships between periodontal diseases and systemic conditions;
- Advanced therapeutic approaches including immunomodulation, targeted antimicrobials, and regenerative strategies;
- Digital technologies, artificial intelligence, and machine learning applications in periodontal diagnostics and treatment planning;
- Precision and personalized approaches to periodontal medicine.
By bringing together diverse perspectives and methodologies, this Special Issue aims to foster interdisciplinary dialogue and collaboration toward a more comprehensive understanding of periodontal diseases and the development of more effective preventive and therapeutic interventions.
Dr. Elisabetta Ferrara
Guest Editor
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Keywords
- periodontitis
- gingivitis
- oral microbiome
- host–pathogen interactions
- periodontal immunology
- systemic inflammation
- salivary diagnostics
- periodontal regeneration
- precision dentistry
- oral-systemic connections
- inflammatory biomarkers
- antimicrobial peptides
- peri-implantitis
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