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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cutting-Edge Methods for Exploiting Bioactive Compounds in Biomasses: From the Plant Matrix to Molecular Function

edited by Chiara Magni

submission deadline 20 May 2026 | 6 articles | Viewed by 9510 | Submission Open

Keywords: plant matrix; agri-food biomasses; biochemistry; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Perspectives on Virus–Host Interactions

edited by

Qibin Geng

submission deadline 20 May 2026 | 6 articles | Viewed by 9414 | Submission Open

Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies

(This special issue belongs to the Section Molecular Microbiology)

Computational Studies in Drug Design and Discovery

edited by

Elena Cichero

submission deadline 20 May 2026 | 4 articles | Viewed by 9100 | Submission Open

Keywords: molecular docking; homology modeling; repositioning; virtual screening; QSAR; molecular dynamics; ADME prediction

(This special issue belongs to the Section Molecular Informatics)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 20 May 2026 | 4 articles | Viewed by 8932 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Endometriosis and Infertility

edited by Ludwig Kiesel

submission deadline 20 May 2026 | 4 articles | Viewed by 8855 | Submission Open

Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compound Delivery Systems and Microbiome Interactions

edited by

Ramona Suharoschi

Adriana Fodor

and

Oana Lelia Pop

submission deadline 20 May 2026 | 2 articles | Viewed by 8771 | Submission Open

Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Amyotrophic Lateral Sclerosis (ALS): Pathogenesis and Treatments

edited by

Monica Consonni

and

Stefania Marcuzzo

submission deadline 20 May 2026 | 2 articles | Viewed by 8749 | Submission Open

Keywords: amyotrophic lateral sclerosis; therapeutic applications; extracellular-vesicles; gene variants; RNA metabolism; mitochondrial dysfunction; oxidative stress; neuroinflammation; protein misfolding; muscle impariment

(This special issue belongs to the Section Molecular Neurobiology)

Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy

edited by

Tetiana Zaǐchuk

submission deadline 20 May 2026 | 5 articles | Viewed by 8650 | Submission Open

Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution

(This special issue belongs to the Section Molecular Oncology)

Fish Immunology, 5th Edition

edited by

Alberto Cuesta

and

Elena Chaves-Pozo

submission deadline 20 May 2026 | 4 articles | Viewed by 8502 | Submission Open

Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation

(This special issue belongs to the Section Molecular Immunology)

Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives

edited by

Anna Weronika Sobańska

submission deadline 20 May 2026 | 1 articles | Viewed by 8442 | Submission Open

Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system

(This special issue belongs to the Section Molecular Biology)

Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications

edited by

Grace Blest Hopley

submission deadline 20 May 2026 | 4 articles | Viewed by 8309 | Submission Open

Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Macrophages and Inflammation

edited by

Julia Kzhyshkowska

submission deadline 20 May 2026 | 2 articles | Viewed by 8275 | Submission Open

Keywords: innate immunity; transcriptional programs; epigenetics; immunometabolism; receptors; scavenging; cytokines; ROS

(This special issue belongs to the Section Molecular Immunology)

Advances in Organic Synthesis in Drug Discovery

edited by

Laura Gabriela Sârbu

submission deadline 20 May 2026 | 3 articles | Viewed by 7920 | Submission Open

Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition

edited by

Elia Ranzato

submission deadline 20 May 2026 | 4 articles | Viewed by 7914 | Submission Open

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Treatment of Migraine

edited by Noboru Imai

submission deadline 20 May 2026 | 1 articles | Viewed by 7869 | Submission Open

Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chromatin Remodelers as Players and Drivers in Pathological States

edited by Matteo De March

submission deadline 20 May 2026 | 3 articles | Viewed by 7838 | Submission Open

Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer

(This special issue belongs to the Section Molecular Biology)

Plant Development and Abiotic Stress Response Regulation via Alternative Splicing

edited by

Yong-Hwan Moon

submission deadline 20 May 2026 | 4 articles | Viewed by 7833 | Submission Open

Keywords: plants; development; abiotic stress responses; alternative splicing; transcriptional regulation; signaling; splicing factors

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition

edited by

Klaus H. Hoffmann

submission deadline 20 May 2026 | 5 articles | Viewed by 7712 | Submission Open

Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology

(This special issue belongs to the Section Molecular Immunology)

Bioprinting: Progress and Challenges

edited by

Rui Vitorino

submission deadline 20 May 2026 | 1 articles | Viewed by 7607 | Submission Open

Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research

(This special issue belongs to the Section Materials Science)

Advances in G Protein-Coupled Receptor Signaling

edited by

Dariusz Szukiewicz

submission deadline 20 May 2026 | 1 articles | Viewed by 7419 | Submission Open

Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗

(This special issue belongs to the Section Molecular Immunology)

Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics

edited by

Elisabetta Ferrara

submission deadline 20 May 2026 | 2 articles | Viewed by 7358 | Submission Open

Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 20 May 2026 | 7 articles | Viewed by 7263 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Pharmacology and Toxicology of Synthetic and Natural Products

edited by

Sherif T.S. Hassan

submission deadline 20 May 2026 | 3 articles | Viewed by 7175 | Submission Open

Keywords: pharmacology and toxicology; pharmacodynamics and pharmacokinetics; synthetic drugs; natural products; drug interactions; molecular mechanisms; therapeutic potential; adverse effects; dose– response relationship; drug safety and efficacy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 20 May 2026 | 2 articles | Viewed by 6982 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Opioid Research

edited by Matthew E. Layton

submission deadline 20 May 2026 | 5 articles | Viewed by 6883 | Submission Open

Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes

(This special issue belongs to the Section Molecular Pharmacology)

Perspectives of Molecular Genetics and Genomics in Human Mendelian Diseases

edited by

Marta Rusmini

submission deadline 20 May 2026 | 3 articles | Viewed by 6853 | Submission Open

Keywords: functional genomics; omics; genetic disease; human; molecular mechanisms; genome editing; biomarkers; computational genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microbiome Connections in Age-Related Diseases

edited by Shalini Jain

submission deadline 20 May 2026 | 3 articles | Viewed by 6604 | Submission Open

Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia

(This special issue belongs to the Section Molecular Microbiology)

Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 20 May 2026 | 4 articles | Viewed by 6432 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Technical Developments and Recent Applications of Cellular Molecular Imaging

edited by Hanae Sato

submission deadline 20 May 2026 | 3 articles | Viewed by 6334 | Submission Open

Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging

(This special issue belongs to the Section Molecular Biology)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 May 2026 | 4 articles | Viewed by 6334 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics

edited by

Ivano Condò

submission deadline 20 May 2026 | 2 articles | Viewed by 6157 | Submission Open

Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 May 2026 | 3 articles | Viewed by 6087 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Extraction, Identification and Quantification of Bioactive Molecules

edited by

Francesca Scionti

and Rosario Mare

submission deadline 20 May 2026 | 2 articles | Viewed by 5937 | Submission Open

Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

From Nature to Medicine: Exploring Natural Products for New Therapies

edited by

Alejandro Madrid

submission deadline 20 May 2026 | 3 articles | Viewed by 5929 | Submission Open

Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Pathogenesis and Treatment of Pregnancy Complications

edited by

Melissa Wilson

submission deadline 20 May 2026 | 3 articles | Viewed by 5926 | Submission Open

Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diagnosis and Treatment of Osteoporosis

edited by

Fabio Vescini

submission deadline 20 May 2026 | 3 articles | Viewed by 5833 | Submission Open

Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

FTIR Miscrospectroscopy: Opportunities and Challenges

edited by Simona Sabbatini

submission deadline 20 May 2026 | 3 articles | Viewed by 5730 | Submission Open

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Anti-cancer Agents: Design, Synthesis and Applications

edited by

Robert Czarnomysy

and

Anna Szymanowska

submission deadline 20 May 2026 | 2 articles | Viewed by 5730 | Submission Open

Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity

(This special issue belongs to the Section Molecular Pharmacology)

The Effects of Dietary Supplements, Functional Foods and Nutraceuticals in the Immune System

edited by

Kaleta Beata

submission deadline 20 May 2026 | 1 articles | Viewed by 5667 | Submission Open

Keywords: dietary supplements; functional foods; immune system; immunomodulation; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles

edited by

Vitaliy Borisov

and

Elena Forte

submission deadline 20 May 2026 | 2 articles | Viewed by 5653 | Submission Open

Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target

(This special issue belongs to the Section Molecular Biophysics)

Neurological Diseases: From Physiology to Therapy

edited by

Vasileios Papaliagkas

submission deadline 20 May 2026 | 2 articles | Viewed by 5588 | Submission Open

Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

edited by

Julita Kulbacka

submission deadline 20 May 2026 | 3 articles | Viewed by 5539 | Submission Open

Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI

(This special issue belongs to the Section Molecular Oncology)

Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds

edited by

Kiril Gavazov

submission deadline 20 May 2026 | 5 articles | Viewed by 5489 | Submission Open

Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Host Responses to Virus Infection

edited by Hideki Hayashi and Yoshinao Kubo

submission deadline 20 May 2026 | 3 articles | Viewed by 5483 | Submission Open

Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm

(This special issue belongs to the Section Molecular Microbiology)

p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

edited by Przemyslaw Bozko

submission deadline 20 May 2026 | 3 articles | Viewed by 5384 | Submission Open

Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pulmonary Hypertension: Molecular Diagnosis, Pathogenesis, Biomarkers and Therapies

edited by Michele Correale

submission deadline 20 May 2026 | 3 articles | Viewed by 5286 | Submission Open

Keywords: pulmonary hypertension; pulmonary arterial hypertension; pulmonary vascular disease; pulmonary circulation; cor pulmonale; chronic lung disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism in Multiple Sclerosis and Related Disorders: 3rd Edition

edited by

Hans-Peter Hartung

and Kazuo Fujihara

submission deadline 20 May 2026 | 3 articles | Viewed by 5285 | Submission Open

Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease-modifying treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 20 May 2026 | 3 articles | Viewed by 5077 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Therapeutics for Respiratory Diseases

edited by

Roberto Plebani

submission deadline 20 May 2026 | 2 articles | Viewed by 4889 | Submission Open

Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 May 2026 | 1 articles | Viewed by 4844 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2601-2650 on page 53 of 68.

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