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Bioactive Compound Delivery Systems and Microbiome Interactions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 278

Special Issue Editors


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Guest Editor
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Calea Manastur Street, 400372 Cluj-Napoca, Romania
Interests: nutrigenomics; metagenomics; metaproteomics; metabolomics; metatranscriptomics; understanding the molecular mechanisms of food compounds; molecular nutrition; personalised nutrition; personalised food; medical foods; aging and chronic disease; aging and NCDs; climate/environment, health, and improved nutrition; diet and cancer; dietary bioactive components; prebiotics fiber; nutrient-gene interactions; nutritional epidemiology; nutritional immunology and inflammation; obesity and microbiome; gut-brain axis; nutritional microbiology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Clinical Center of Diabetes, Nutrition and Metabolic Diseases, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor St., 400012 Cluj-Napoca, Romania
Interests: oxidative stress; antioxidant polyphenols; anti-inflammatory; antimicrobial polyphenols; bioactive compound; biological activities
Special Issues, Collections and Topics in MDPI journals

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Guest Editor

Special Issue Information

Dear Colleagues,

Bioactive compounds and nutraceuticals have grown significantly in recent years, and extensive research has been conducted on their health-promoting properties for various conditions, including cancer, cardiovascular diseases, and neurological disorders. However, a critical analysis of the current research landscape reveals significant gaps that limit these promising compounds' clinical translation and efficacy.

Two significant challenges stand out as follows: (1) the poor bioavailability and stability of many bioactive compounds in vivo and (2) the limited understanding of how individual variations, particularly in gut microbiome composition, influence the efficacy of bioactive interventions. Additionally, there is a growing consensus that the future of nutrition science lies in personalized approaches that account for individual genetic, metabolic, and microbiome profiles.

This Special Issue aims to address these interconnected research gaps by focusing on innovative delivery systems for bioactive compounds and their interactions with the gut microbiome. The ultimate goal is to advance personalized nutrition approaches.

This Special Issue will bring together cutting-edge research on the following topics:

  1. Novel delivery systems for bioactive compounds that enhance bioavailability, stability, and targeted delivery;
  2. Microbiome–bioactive interactions that influence the metabolism, bioavailability, and efficacy of bioactive compounds;
  3. Personalized nutrition approaches that leverage individual variations in response to bioactive compounds;
  4. Synergistic effects between multiple bioactive compounds and the microbiome.

Prof. Dr. Ramona Suharoschi
Dr. Adriana Fodor
Dr. Oana Lelia Pop
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • delivery systems
  • gut microbiome
  • personalized nutrition
  • bioavailability
  • encapsulation technologies
  • microbiome–bioactive interactions
  • targeted delivery
  • precision nutrition
  • synergistic interactions

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Published Papers

This special issue is now open for submission.
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