Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1897
Special Issue Editor
Interests: apoptosis; epigenetics; DNA; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A better understanding of the complex ecosystem of dynamically interacting cancer, non-malignant cells, and the extracellular matrix (ECM) which create the tumor microenvironment (TME) has significantly impacted cancer research.
This field has made impressive strides in illuminating the diverse cell populations within tumors and the interactions between them and with the ECM, discovering mechanisms of immune response modulation and detecting how the TME supports metabolic changes reprogrammed by tumors and enhances tumor progression. Continuously improving tumor models helps researchers understand TME interactions in a more clinically relevant context and evaluate new treatments. One critical challenge is effectively targeting the diverse subpopulations of cells within a tumor, including those that contribute to resistance. Understanding the dynamic interplay between various cell types, signaling pathways, and extracellular matrix components in different tumor types and stages is an ongoing issue.
In this Special Issue, we aim to collect high-quality research papers addressing the complexity of TME interactions, tumor heterogeneity, the development of biomarkers guiding personalized treatment, resistance to therapies targeting the TME or in which the TME is involved, immune editing, and tumor evolution.
Dr. Tetiana Zaǐchuk
Guest Editor
Manuscript Submission Information
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Keywords
- tumor microenvironment
- immune response modulation
- signaling pathways
- extracellular matrix components
- tumor evolution
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