Endometriosis and Infertility
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 3980
Special Issue Editor
Interests: endometriosis; cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endometriosis is often associated with subfertility or infertility in women. The detailed mechanisms of this interrelationship have yet to be determined. The presence of endometriosis may cause infertility depending on the extent and characteristics of the disease. However, we still lack adequate markers to determine the relevance of endometriosis with regard to the cause, prognosis, and prediction of the effect of medical and non-medical treatment modalities. Major anatomical changes of the reproductive organs caused by endometriosis are regarded as potential mechanisms that interfere with various reproductive aspects, e.g., tubal infertility. The role of endometrioma as well deep endometriosis of the bowel in infertility has been debated for many years. It is still unclear in which cases surgery is required and, if so, which techniques should be applied. In addition to mechanistic aspects, the potential effect of endometriosis could be due to molecular alterations. Various factors such as immunological, endocrine, inflammatory, etc., have been demonstrated to be differentially regulated in women suffering from endometriosis, which may be relevant in reproduction. Although the commonly used endocrine therapies are often effective for pain relief in many women, these treatment modalities cannot be administered for fertility treatment, due to their contraceptive action. This is certainly one of the major unmet needs when treating endometriosis-associated infertility. Therefore, future research on the factors of endometriosis interfering with the physiological mechanisms of reproduction should advance the development of new agents as effective medical treatments in these women.
Prof. Dr. Ludwig Kiesel
Guest Editor
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Keywords
- endometriosis
- infertility
- subfertility
- physiological mechanisms
- treatments
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