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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Virus Detection and Analysis: Molecular Investigations

edited by

Hayes Kam-Hei Luk

submission deadline 26 May 2026 | Viewed by 81 | Submission Open

Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Strategies Targeting Cancer Stem Cells

edited by Luciano Vellón

submission deadline 28 May 2026 | Viewed by 67 | Submission Open

Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer

(This special issue belongs to the Section Molecular Oncology)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 30 May 2026 | 1 articles | Viewed by 3731 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis, and Biological Evaluation of Novel Bioactive Compounds

edited by Monika Wujec and Oleg M. Demchuk

submission deadline 30 May 2026 | Viewed by 510 | Submission Open

Keywords: drug design; organic compounds; heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; structure– activity relationships (SARs); organic synthesis; natural product

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Evolution of the Vertebrate Immune System

edited by

Pierre Pontarotti

submission deadline 30 May 2026 | Viewed by 246 | Submission Open

Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias

edited by Yingjie Liu

submission deadline 30 May 2026 | Viewed by 162 | Submission Open

Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies

(This special issue belongs to the Section Molecular Biology)

Nanostructured Strategies for Bioactive Compounds

edited by

Karen Khachatryan

submission deadline 30 May 2026 | Viewed by 60 | Submission Open

Keywords: nanostructure-bioactive interaction; molecular encapsulation mechanisms; metallic nanoparticles (bioactivity); carbon-based nanocarriers; nano/microcapsule delivery systems; bioactive compound stabilisation; structure-activity relationships; molecular release kinetics

(This special issue belongs to the Section Molecular Biology)

Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products

edited by Emira D’Amico

submission deadline 30 May 2026 | Viewed by 59 | Submission Open

Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals

(This special issue belongs to the Section Molecular Biology)

Oral Diseases and Oral Soft Tissue Repair

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 51 | Submission Open

Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytokines and Inflammatory Diseases

edited by

Pio Conti

submission deadline 30 May 2026 | Viewed by 37 | Submission Open

Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation

(This special issue belongs to the Section Molecular Immunology)

Extracellular Matrix Signalling in Health and Disease

edited by

Helen L. Birch

submission deadline 30 May 2026 | Viewed by 23 | Submission Open

Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions

edited by

Daniele La Russa

and

Daniela Pellegrino

submission deadline 30 May 2026 | Viewed by 21 | Submission Open

Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Engineering Cell-Derived Nanostructures for Therapeutic Delivery

edited by

Tania Limongi

submission deadline 30 May 2026 | Viewed by 21 | Submission Open

Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Hormetic Responses of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 30 May 2026 | Viewed by 6 | Submission Open

Keywords: hormesis; environmental stress; dose– response; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Oral Cancer: From Molecular Mechanisms to Therapeutics

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 4 | Submission Open

Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology

(This special issue belongs to the Section Molecular Oncology)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 May 2026 | 2 articles | Viewed by 1118 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiota-Mediated Regulation of Stem Cells in Cancer Initiation, Progression, and Treatment Response

edited by

Ciro Gargiulo Isacco

submission deadline 31 May 2026 | Viewed by 311 | Submission Open

Keywords: microbiota stem cell cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Infections and Viral Pathogenesis

edited by

Shymaa E. Bilasy

submission deadline 31 May 2026 | Viewed by 83 | Submission Open

Keywords: viral pathogenesis; viral– host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy

(This special issue belongs to the Section Molecular Microbiology)

Advances in the Pharmacology of Depression and Mood Disorders

edited by

Guillaume Lucas

submission deadline 31 May 2026 | Viewed by 63 | Submission Open

Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation

edited by Rosanna Avola

submission deadline 31 May 2026 | Viewed by 59 | Submission Open

Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular and Molecular Mechanisms of Neuroinflammation

edited by

Maria Anttonietta Panaro

submission deadline 31 May 2026 | Viewed by 58 | Submission Open

Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models

edited by

Oleksii Skorokhod

submission deadline 31 May 2026 | Viewed by 54 | Submission Open

Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 May 2026 | Viewed by 53 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Microorganisms and Invertebrates in Molecular Dialogue: Mechanisms, Dynamics, and Applications

edited by

Monika Mioduchowska

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: microorganism– invertebrate interactions; symbiosis; stress tolerance; co-evolution; omics approaches; biotechnological applications

(This special issue belongs to the Section Molecular Microbiology)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Platelet-Mediated Immune Regulation in Cancer

edited by

Bennett D. Elzey

submission deadline 31 May 2026 | Viewed by 28 | Submission Open

Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis

(This special issue belongs to the Section Molecular Immunology)

Genetic and Molecular Insights into Aging in Vertebrate Models

edited by Antonio Palladino

submission deadline 31 May 2026 | Viewed by 22 | Submission Open

Keywords: aging; vertebrate models; molecular mechanisms; cellular senescence; translational medicine

(This special issue belongs to the Section Molecular Biology)

Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis

edited by

R. Holland Cheng

submission deadline 31 May 2026 | Viewed by 19 | Submission Open

Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design

(This special issue belongs to the Section Macromolecules)

Physiological and Molecular Responses of Plants to Drought Stress

edited by

Muhammad Waseem

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Ferroptosis in Cancer Biology and Therapy

edited by Alessandra Di Paola and Elvira Pota

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: ferroptosis; cancer biology; tumor microenvironment; therapeutic targeting; anticancer immunity; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Metabolic Alterations in Health and Disease: From Molecular Mechanisms to Biomarkers in Clinical Applications

edited by

Ramona D'Amico

and

Rosalba Siracusa

submission deadline 31 May 2026 | Viewed by 12 | Submission Open

Keywords: metabolic syndrome; diabetes; oxidative stress; cellular metabolism; biomarkers; molecular pathways; metabolic disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Crosstalk in Allergy, Barrier Dysfunction, and Asthma

edited by

Elisa Boni

submission deadline 31 May 2026 | Viewed by 9 | Submission Open

Keywords: barrier dysfunction; asthma; allergy; molecular pathways; molecular crosstalks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Functional Activity of Natural Products

edited by

Antonio Speciale

submission deadline 31 May 2026 | Viewed by 9 | Submission Open

Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 20 Jun 2026 | 7 articles | Viewed by 13918 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments

edited by

Luisa Agnello

and Anna Maria Ciaccio

submission deadline 20 Jun 2026 | 3 articles | Viewed by 8531 | Submission Open

Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Myocardial Disease: Molecular Pathology and Treatments

edited by

Kazufumi Nakamura

submission deadline 20 Jun 2026 | 3 articles | Viewed by 8105 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; amyloidosis; myocarditis; sarcoidosis; genetic abnormalities; immune mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Acute Myeloid Leukemia

edited by

Walter Fiedler

submission deadline 20 Jun 2026 | 4 articles | Viewed by 8018 | Submission Open

Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Skin Diseases: 3rd Edition

edited by

Naoko Kanda

submission deadline 20 Jun 2026 | 3 articles | Viewed by 7487 | Submission Open

Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cardiac Disease

edited by

Daniela Rossin

submission deadline 20 Jun 2026 | 2 articles | Viewed by 5944 | Submission Open

Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

edited by

Oriana Trubiani

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Jun 2026 | 2 articles | Viewed by 5430 | Submission Open

Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Radiation-Induced DNA Damage and Toxicity

edited by

Mohammad Asif Sherwani

and

Muhammad Maqbool

submission deadline 20 Jun 2026 | 3 articles | Viewed by 4276 | Submission Open

Keywords: radiation; DNA damage; toxicity; immune response

(This special issue belongs to the Section Molecular Biology)

Plant Pathogen Interactions: 3rd Edition

edited by

Sixue Chen

submission deadline 20 Jun 2026 | 1 articles | Viewed by 3606 | Submission Open

Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Glycoconjugates: From Structure to Therapeutic Application

edited by Rosana Ribić

submission deadline 20 Jun 2026 | 4 articles | Viewed by 3474 | Submission Open

Keywords: glycoconjugates (glycoproteins and glycopeptides; glycolipids; proteoglycans); glyconanoparticles; carbohydrate-based therapeutics; glycomics; glycosylation; glycoengineering; glycobiology; synthesis of glycoconjugates; vaccine development; drug delivery; biomarkers; diagnostics; immunotherapy; regenerative medicine; therapeutic applications

(This special issue belongs to the Section Molecular Pharmacology)

New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition

edited by

Federica Mannino

submission deadline 20 Jun 2026 | 2 articles | Viewed by 2973 | Submission Open

Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media

edited by

Ana M. Mainar

and

José S. Urieta

submission deadline 20 Jun 2026 | 1 articles | Viewed by 2913 | Submission Open

Keywords: water solubility ; water-solute interactions ; solvation; hydrophobic and hydrophilic effects ; improving water solubility and prediction ; solution of chemicals in biological media ; diffusivity ; drug transport and bioavailability; chemicals diffusivity across biological barriers

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Bioactive Compounds and Their Antioxidant Role: 2nd Edition

edited by Tamara Jurina

submission deadline 20 Jun 2026 | 3 articles | Viewed by 2725 | Submission Open

Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Aspects of Reproductive Medicine

edited by Wei Chen

submission deadline 20 Jun 2026 | 1 articles | Viewed by 2564 | Submission Open

Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1979 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

Role of Immune Cells in Cancers

edited by Helga Maria Schmetzer

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1836 | Submission Open

Keywords: cancer; immune monitoring; immune escape; immune activation

(This special issue belongs to the Section Molecular Oncology)

Advances in Brassica Crop Metabolism and Genetics (Second Edition)

edited by

Bo Sun

and

Honghao Lv

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1682 | Submission Open

Keywords: brassica crop; genomics; transcriptomics; proteomics; metabolomics; gene editing; metabolite synthesis and regulation; phylogeny and taxonomy; physiological traits; biotic/abiotic stresses; biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 3301-3350 on page 67 of 69.

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