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Nanostructured Strategies for Bioactive Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 750

Editor

Special Issue Information

Dear Colleagues,

We are delighted to announce a forthcoming Special Issue of IJMS dedicated to "Nanostructured Strategies for Bioactive Compounds". We warmly invite researchers to contribute original research articles and reviews that explore the cutting-edge intersection of advanced nanomaterials and bioactive agents.

This issue seeks to highlight innovative research on the design, synthesis, characterisation, and molecular-level interactions of diverse nanostructures. Key areas of interest include:

  • Metallic nanostructures (e.g., silver and gold nanoparticles) and carbon-based nanomaterials (graphene oxide, carbon nanotubes, and quantum dots) for bioactive delivery or functional composites.
  • Nanoencapsulation systems, such as nanocapsules and liposomes, engineered to protect, deliver, and control the release of bioactive payloads.
  • The integration and synergistic effects of natural bioactive compounds (e.g., plant extracts, essential oils, antimicrobial peptides) and synthetic bioactive molecules with nanostructured carriers or matrices.
  • Molecular mechanisms underpinning the bioactivity, stability, release kinetics, and biocompatibility of these hybrid systems.

Crucially, as IJMS is fundamentally focussed on molecular research, all submitted manuscripts must include substantive molecular data or analysis. This could involve detailed characterisation of molecular interactions (e.g., spectroscopy, binding studies), structure-property relationships at the molecular level, molecular modelling, or investigations into the molecular basis of biological effects (e.g., gene expression, enzyme inhibition, receptor binding studies related to the nanostructures/bioactives).

We encourage submissions that provide deep molecular insights into how nanostructures enhance the efficacy, stability, or targeting of bioactive compounds for applications spanning biomedicine, active packaging, antimicrobials, agriculture, and functional materials.

Dr. Karen Khachatryan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • nanostructure-bioactive interaction
  • molecular encapsulation mechanisms
  • metallic nanoparticles (bioactivity)
  • carbon-based nanocarriers
  • nano/microcapsule delivery systems
  • bioactive compound stabilisation
  • structure-activity relationships
  • molecular release kinetics

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Published Papers (1 paper)

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Research

13 pages, 2124 KB  
Article
Synthesis of Silver Phosphate (Ag3PO4) and Its Supplementation to Enhance Phytochemical Accumulation and Antioxidant Activity of Cryptocoryne albida Under Hydroponic Cultivation
by Somkiat Seesanong, Banjong Boonchom, Chaowared Seangarun, Nongnuch Laohavisuti, Benyakorn Labantao, Pesak Rungrojchaipon, Sirichet Punthipayanon and Wimonmat Boonmee
Int. J. Mol. Sci. 2026, 27(14), 6235; https://doi.org/10.3390/ijms27146235 - 13 Jul 2026
Viewed by 268
Abstract
This study investigated the supplementation of silver phosphate (Ag3PO4) to enhance the growth and antioxidant activity of Cryptocoryne albida in a hydroponic system. Ag3PO4 was synthesized via a simple precipitation method using AgNO3 and (NH [...] Read more.
This study investigated the supplementation of silver phosphate (Ag3PO4) to enhance the growth and antioxidant activity of Cryptocoryne albida in a hydroponic system. Ag3PO4 was synthesized via a simple precipitation method using AgNO3 and (NH4)2HPO4 as precursors, with alcohol employed as the reaction medium to control particle growth and agglomeration. FTIR analysis confirmed the presence of characteristic phosphate (PO43−) functional groups, while XRD revealed diffraction peaks consistent with Ag3PO4 as the dominant crystalline phase. The SEM image exhibits relatively uniform spherical particles of 300–500 nm. Moreover, the XRF results for the synthesized Ag3PO4 indicated 86.80% of Ag2O and 12.60% of P2O5 as the major components. The application experiment was conducted in a DFT hydroponic system containing different concentrations of Ag3PO4-derived supplementation (0.00, 0.01, 0.10, and 1.00 ppm). The highest concentration (1.00 ppm) of Ag3PO4 in the KMITL2 nutrient solution significantly reduced plant growth (p < 0.05). In contrast, Ag3PO4-derived supplementation with 0.01 ppm resulted in significantly higher phytochemical accumulation, including total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities evaluated by DPPH and ABTS assays (p < 0.05). These results suggest that low-concentration Ag3PO4-derived supplementation may promote phytochemical accumulation and antioxidant activity in C. albida. Overall, this study highlights the potential of Ag3PO4-derived supplementation for modulating phytochemical accumulation and antioxidant activity in hydroponically cultivated C. albida. Full article
(This article belongs to the Special Issue Nanostructured Strategies for Bioactive Compounds)
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