Genetic and Molecular Insights into Aging in Vertebrate Models

Dear Colleagues,

Aging is a complex and multifactorial biological process that affects all organ systems and represents one of the main challenges for modern biomedical research. As life expectancy continues to rise worldwide, the incidence of age-related diseases is increasing, profoundly impacting the quality of life and healthcare systems. Understanding the genetic and molecular mechanisms that underlie aging and its associated pathologies has therefore become a key priority in translational medicine. Vertebrate models play a pivotal role in this context, offering invaluable tools to dissect the pathways regulating cellular senescence, tissue degeneration, and longevity. Over the past decades, several vertebrate species have been used to investigate aging-related mechanisms at morphological, physiological, and molecular levels, providing insights into conserved processes and potential therapeutic targets. This Special Issue aims to gather cutting-edge studies addressing the genetic, molecular, and cellular bases of aging in vertebrate models, from fish to mammals. We welcome contributions that explore innovative experimental approaches, novel biomarkers of aging, molecular interventions aimed at delaying senescence, and translational strategies with potential biomedical applications. Original research articles, reviews, and short communications are invited. Studies combining morphological, physiological, and omics-based methodologies will be particularly appreciated. All accepted contributions will be published promptly after peer review, fostering an integrated view of aging across vertebrate taxa.

Dr. Antonio Palladino
Guest Editor

Manuscript Submission Information

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