Oral Cancer: From Molecular Mechanisms to Therapeutics

Dear Colleagues,

Oral cancer remains a major global health challenge, representing a significant cause of morbidity and mortality worldwide. Despite advances in diagnosis and treatment, the overall survival rate for patients with oral cancer has not improved significantly in recent decades. A deeper understanding of the genetic, epigenetic, and molecular alterations involved in oral cancer is thus essential for identifying novel biomarkers for early detection, prognosis, and treatment response. In addition, innovative therapeutic strategies—including immunotherapy, targeted molecular treatments, and nanomedicine—offer new hope for improved outcomes.

This Special Issue aims to provide a comprehensive overview of the most recent discoveries in the molecular mechanisms underlying oral carcinogenesis, progression, and metastasis, as well as emerging therapeutic approaches. We welcome original research articles, reviews, and perspectives covering basic, translational, and clinical studies. Contributions that explore novel molecular pathways, tumor microenvironment interactions, resistance mechanisms, or clinical trials are particularly encouraged. With this Special Issue, we aim to foster interdisciplinary dialogue and stimulate further research that could ultimately improve patient care in oral oncology.

Dr. Diana Russo
Guest Editor

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