Cytokines and Inflammatory Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 May 2026 | Viewed by 9
Special Issue Editor
Interests: inflammation; innate immunity; cell culture; immunology of infectious diseases; psoriasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cytokines are mediators of the immune system and inflammatory diseases and play an important role in clinical pathogenesis. Cytokines are proteins produced primarily by immune cells such as T lymphocytes, macrophages, dendritic cells, neutrophils, basophils, and mast cells. In addition, fibroblasts, endothelial cells, epithelial cells, and other cells can also produce cytokines. Cytokines function as intercellular messengers that regulate the inflammatory and immune response. They can be classified based on their function: pro-inflammatory, such as TNF, IL-1, IL-6, IL-8, IFN-γ, and others; and anti-inflammatory, which limit the immune response, such as IL-10, TGF-β, IL-37, IL-1RA, IL-38, etc. Cytokine receptors are specific membrane proteins that activate intracellular signaling pathways. Type I and II receptors activate JAK-STAT signaling, while IL-1/TLR-like receptors activate the MyD88 pathway with the formation of NF-κB/MAPK. Cytokines are involved in many inflammatory diseases, including rheumatoid arthritis, where they activate the synovial joints and cause cartilage and bone destruction. In Crohn's disease/ulcerative colitis, they cause chronic intestinal inflammation and Th1/Th17 dysregulation, and in psoriasis, they mediate keratinocyte proliferation and dermal inflammation.
Prof. Dr. Pio Conti
Guest Editor
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Keywords
- inflammation
- cytokines
- interleukin-6
- immune diseases
- immune signaling
- autoimmunity
- brain inflammation
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