The Role of Ferroptosis in Cancer Biology and Therapy

Dear Colleagues,

Ferroptosis has emerged as a distinct and tightly regulated form of cell death, driven by iron-dependent lipid peroxidation and interconnected with cellular metabolism and redox balance. In the context of cancer biology, ferroptosis plays a dual and context-specific role, acting as both a tumor-suppressive and tumor-promoting process. Understanding how ferroptosis interacts with oncogenic signaling, metabolic reprogramming, and the tumor microenvironment remains a central challenge in the field.

Interestingly, mesenchymal and therapy-resistant cancer cells display a particular vulnerability to ferroptosis, opening new perspectives for targeted interventions in refractory malignancies. At the same time, the modulation of ferroptosis can influence anticancer immunity and treatment outcomes, underscoring the need for a precise therapeutic balance.

This Special Issue aims to explore the multifaceted role of ferroptosis in cancer biology, from its molecular determinants to its translational potential. We invite contributions that elucidate the mechanisms regulating ferroptosis in tumor cells, its impact on the tumor–immune interface, and innovative strategies to harness ferroptosis modulation for effective cancer therapy.

Dr. Alessandra Di Paola
Dr. Elvira Pota
Guest Editors

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