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IJMS
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Oral Diseases and Oral Soft Tissue Repair
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Oral Diseases and Oral Soft Tissue Repair

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 550

Special Issue Editor

Dr. Diana Russo

E-Mail Website
Guest Editor
Oral Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, Italy
Interests: dental; oral medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue “Oral Diseases and Oral Soft Tissue Repair” of the International Journal of Molecular Sciences (IJMS) focuses on molecular, translational, and clinical advances in the diagnosis, treatment, and regeneration of oral soft tissues, as well as on the pathophysiological mechanisms underlying major oral diseases. Its aim is to promote an integrated perspective combining molecular biology, materials science, and regenerative biotechnology to develop innovative strategies for the healing and restoration of gingival, mucosal, and periodontal tissues. The issue welcomes contributions addressing biomaterials, bioactive scaffolds, growth factors, autologous proteins, RNA-based technologies (including lipid nanoparticle systems containing modified mRNA), platelet-rich preparations, and antimicrobial strategies designed to enhance tissue repair and reduce infection risk in the oral cavity. Special emphasis is placed on understanding the interactions between biomaterials, cells, and host tissues, and on translating molecular discoveries into safe and effective clinical therapies. Original research articles, reviews, and short communications are invited to expand current knowledge and therapeutic perspectives in oral soft tissue repair and oral disease management.

Dr. Diana Russo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • tissue regeneration
  • photobiomodulation
  • periodontology
  • implant dentistry

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Published Papers (1 paper)

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Research

17 pages, 3865 KB  
Article
Platelet-Rich Fibrin in Surgical Wound Healing of Medication-Related Osteonecrosis of the Jaw: A Pilot Clinical Study
by Aleksy Nowak, Aleksandra Rudzka, Piotr Skrzypczak, Krzysztof Osmola and Marzena Liliana Wyganowska
Int. J. Mol. Sci. 2026, 27(8), 3654; https://doi.org/10.3390/ijms27083654 - 20 Apr 2026
Viewed by 325
Abstract
Medication-related osteonecrosis of the jaw (MRONJ) represents a major clinical challenge for oral and maxillofacial surgery departments as well as dental practices. With increasing life expectancy and the more frequent use of medications associated with osteonecrosis, the incidence of MRONJ continues to rise. [...] Read more.
Medication-related osteonecrosis of the jaw (MRONJ) represents a major clinical challenge for oral and maxillofacial surgery departments as well as dental practices. With increasing life expectancy and the more frequent use of medications associated with osteonecrosis, the incidence of MRONJ continues to rise. To date, there are no uniform treatment standards with scientifically proven effectiveness for this condition. To evaluate the impact of platelet-rich fibrin (PRF) on the outcomes of MRONJ treatment and to identify factors that may influence the effectiveness of PRF therapy, we conducted a comparative prospective study including 22 patients divided into two groups: patients treated with PRF and patients treated without PRF. PRF was prepared according to the PRF Duo Quattro Process protocol for PRF (Nice, France). The study was registered at ClinicalTrials.gov (NCT07464678). The following parameters were assessed: age, smoking status, gender, lesion location, body mass index (BMI), C-reactive protein (CRP) concentration, pain intensity, presence or absence of fistulas, soft tissue healing and radiological findings. Patients were evaluated preoperatively and postoperatively at 14 days, 6 weeks, and 6 months. The study demonstrated a reduction in pain after surgery among patients treated with PRF. In addition, the use of PRF resulted in improved healing outcomes in patients with elevated CRP. Higher BMI was associated with poorer therapeutic response to PRF. Improvements in soft tissue healing and disease stage were observed in the PRF group; however, these differences did not reach statistical significance. All findings should be interpreted with caution due to the limited sample size. There is still no standardized treatment for MRONJ. The use of platelet-rich fibrin as an inexpensive and safe adjunctive therapy may provide clinical benefits for patients, particularly through a significant reduction in pain. Further large-scale, multicenter studies are required to confirm these findings. Full article
(This article belongs to the Special Issue Oral Diseases and Oral Soft Tissue Repair)
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